RESUMEN
The assessment of the human risk of mutagens is a constituent of the general assessment of the risk of environment-pollutant chemicals to the population's health. An algorithm of assessing the risk of mutagens is proposed. Stage 1 (hazard identification) is to provide an expert analytical characterization of the mutagenic potential of the chemicals polluting the study object. Stage 2 (hazard characterization) is to analyze the quantitative dependences of the effect of mutagens in gametes and somatic cells of man and mammals. Stage 3 (effect evaluation) is to characterize the sources of pollution and the doses of mutagens affecting the population. Stage 4 (risk characterization) is to calculate the risk of mutagens to the population and individuals.
Asunto(s)
Exposición a Riesgos Ambientales/efectos adversos , Enfermedades Ambientales/inducido químicamente , Mutágenos/efectos adversos , Animales , Enfermedades Ambientales/epidemiología , Humanos , Prevalencia , Medición de Riesgo , Factores de Riesgo , Federación de Rusia/epidemiologíaRESUMEN
Development and regression of experimental atherosclerosis in rabbits is an expressed age-related phenomenon, showing the increase in occurrence and pronouncement of atherosclerotic process with age. A new approach to the disease treatment by means of olivomycin is described. It has shown that while influencing considerably the protein biosynthesis of experimental animal, one can accelerate the regression of atherosclerosis by means of olivomycin and reduce protein and lipid metabolism indicators characterizing the disease development.