RESUMEN
There are optical and mechanical advantages of the biconvex posterior chamber intraocular lens (IOL) following cataract surgery. A clinical study of Nd:YAG laser capsulotomy in eyes with biconvex IOLs was undertaken. The lenses were made of injection-molded poly(methyl methacrylate) without laser spacing. Using specified techniques, YAG laser capsulotomy was performed in 19% of 436 eyes without significant damage to the IOL and without affecting visual acuity or glare disability.
Asunto(s)
Terapia por Láser , Cápsula del Cristalino/cirugía , Cristalino/cirugía , Lentes Intraoculares , Extracción de Catarata , Humanos , Metilmetacrilatos/uso terapéutico , Óptica y FotónicaRESUMEN
N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry as dimethylkynuramine (DMK). The enzyme responsible for this appears to be different from tryptophan 2,3-dioxygenase and also from indoleamine 2,3-dioxygenase.
Asunto(s)
N,N-Dimetiltriptamina/sangre , Triptaminas/sangre , Radioisótopos de Carbono , Fenómenos Químicos , Química , Cromatografía Líquida de Alta Presión , Desipramina/sangre , Eritrocitos/metabolismo , Humanos , Técnicas In Vitro , Kinuramina/análogos & derivados , Kinuramina/sangre , Espectrometría de Masas , Plasma/metabolismo , Espectrofotometría UltravioletaRESUMEN
Carbidopa, an aromatic acid decarboxylase inhibitor, has been shown to significantly decrease the pineal concentration of melatonin, N-acetyl serotonin (NAS), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) but not the hypothalamic concentrations of these indoles. Increased levels of 5-hydroxytryptophan (5-HTP) indicate that carbidopa directly inhibits 5-HTP decarboxylation, thus limiting 5-HT production. Possible practical implications of selective inhibition of pineal indoleamines by carbidopa are discussed.