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Objective: To evaluate tooth displacement and periodontal stress generated by the dual action vertical intra-arch technique (DAVIT) for open-bite correction using three-dimensional finite element analysis. Methods: A three-dimensional model of the maxilla was created by modeling the cortical bone, cancellous bone, periodontal ligament, and teeth from the second molar to the central incisor of a hemiarch. All orthodontic devices were designed using specific software to reproduce their morpho-dimensional characteristics, and their physical properties were determined using Young's modulus and Poisson's coefficient of each material. A linear static simulation was performed to analyze the tooth displacements (mm) and maximum stresses (Mpa) induced in the periodontal ligament by the posterior intrusion and anterior extrusion forces generated by the DAVIT. Results: The first and second molars showed the greatest intrusion, whereas the canines and lateral incisors showed the greatest extrusion displacement. A neutral zone of displacement corresponding to the fulcrum of occlusal plane rotation was observed in the premolar region. Buccal tipping of the molars and lingual tipping of the anterior teeth occurred with intrusion and extrusion, respectively. Posterior intrusion generated compressive stress at the apex of the buccal roots and furcation of the molars, while anterior extrusion generated tensile stress at the apex and apical third of the palatal root surface of the incisors and canines. Conclusions: DAVIT mechanics produced a set of beneficial effects for open-bite correction, including molar intrusion, extrusion and palatal tipping of the anterior teeth, and occlusal plane rotation with posterior teeth uprighting.

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INTRODUCTION: Different types of intraradicular restorations and their insertion have an impact on teeth biomechanics. This study aimed to analyze the biomechanical behavior of maxillary central incisors restored with glass fiber post (GFP) and cast metal post and core (CMP) subjected to buccolingual and mesiodistal orthodontic forces using the finite element method. METHODS: Two models of the maxillary central incisor with periodontal ligament, cortical bone, and trabecular bone were made. One of the models included intraradicular restoration with GFP, whereas, in the other, the incisor was restored with CMP. After creating the tridimensional mesh of finite elements, applying 2 orthodontic forces were simulated: 65 g of buccolingual force and 70 g of mesiodistal force. The forces were applied parallel to the palatal plane in the region of the bracket slot, located 4 mm to the incisal edge. RESULTS: The maximum stresses generated in the GFP-restored root were 3.642 × 10-1 MPa and 4.755 × 10-1 MPa from the buccolingual and mesiodistal forces, respectively. Likewise, the stresses in the CMP restored root were 2.777 × 10-1MPa and 3.826 × 10-1MPa. The radicular area with higher stress on both models was located in the cervical third: on the buccal surface when the buccolingual force was applied and on the mesial surface when the mesiodistal force was applied. The highest stress levels were found on the CMP structure. CONCLUSIONS: The incisor restored with cast metal post revealed lower stress values transferred to the root than the one restored with GFP. The stresses on the structure of the GFP were lower and more homogeneous than the ones found on the cast metal post. The difference among the stress values in the materials is within a safe margin for using both materials in relation to orthodontic forces.

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The mechanical behavior of each type of pacifier on rigid structures and their various impacts on orofacial growth have yet to be discovered. The study aimed to evaluate the stress distribution over a child's palate by three types of pacifiers using finite element analysis and clinical and laboratory data. Modulus of elasticity was obtained from 30 specimens comprising 10 of each conventional (A), orthodontic (B), and breast-shaped (C) pacifiers. Tongue strength was assessed in eight 3-year-old children (kPa). A hemi-maxilla model was obtained from 2- to 3-year-old skull tomography, and the images of pacifiers A, B, and C were captured using 3D scanning. The Hypermesh® program generated a mesh of 6-node tetrahedral elements for applying forces in the X, Y, and Z directions to enable a nonlinear analysis. Pacifier B exhibited the highest values for distributed stress on the palate, followed by pacifier A. Pacifier B stimulated the maxilla forward and sideways. In contrast, pacifier A promoted a forward and upward load, favoring a more atresic palate. Pacifiers A and B tended to rotate in the sagittal plane, generating tensions in the anterior incisors and favoring the open bite. Pacifier C exhibited lateral expansion by stress induction over the mid-palatal suture with less influence on incisor inclination. Pacifiers showed different detrimental stress distributions on the palate. This information can be helpful for improving recommendations given to parents.

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Response surface methodology (RSM) consists of mathematical and statistical techniques to develop models which help to understand the influence of various factors on a dependent variable of interest. The feasibility of RSM use to detect cases of periodontitis and its correlated factors has not yet been evaluated. This study developed mathematical models for periodontitis diagnosis independent of periodontal probing using the RSM. Demographic, socioeconomic, behavioral, systemic, local factors, and periodontitis were assessed in 176 volunteers. Periodontitis case was defined according to three different definitions: 1) ≥3 sites with clinical attachment level (CAL) ≥4 mm; 2) at least one site with CAL ≥4 mm and bleeding on probing; 3) ≥2 proximal sites with CAL ≥3 mm and ≥2 proximal sites with probing depth (PD) ≥4 mm (not on the same tooth) OR 1 site with PD ≥5 mm. 4th-degree polynomial equations showed high coefficients of determination (R²= 1) and were used to represent the mathematical models of periodontitis cases. According to definition 1, the diagnosis of periodontitis was accurate by including in the model: age, sex, education level, plaque index (PI), number of missing teeth, previous hygiene instructions, and body mass index (BMI). According to definition 2, the diagnosis of periodontitis was accurate by including in the model: age, sex, education level, income, PI, previous oral hygiene instructions, frequency of brushing and type of toothbrush, and use of mouthwash in the model. For an accurate diagnosis of periodontitis according to definition 3, the model included: age, education level, IP, number of missing teeth, previous oral hygiene instruction, BMI, and diabetes. The multifactorial mathematical models were able to diagnosis periodontitis according to different periodontitis case definitions using only variables of easy evaluation and non-invasive. (AU)

A metodologia de superfície de resposta (MSR) consiste em técnicas matemáticas e estatísticas para desenvolver modelos que ajudam a entender a influência de vários fatores em uma variável dependente de interesse. A viabilidade do uso da MSR para detectar casos de periodontite e seus fatores correlacionados ainda não foi avaliada. Este estudo desenvolveu modelos matemáticos para diagnóstico de periodontite independente da sondagem periodontal usando a MSR. Fatores demográficos, socioeconômicos, comportamentais, sistêmicos, locais e periodontite foram avaliados em 176 voluntários. O caso de periodontite foi definido de acordo com três definições diferentes: 1) ≥3 locais com nível de inserção clínica (NIC) ≥4 mm; 2) Um local com NIC ≥4 mm e sangramento à sondagem; 3) ≥2 locais proximais com NIC ≥3 mm e ≥2 locais proximais com profundidade de sondagem (PS) ≥4 mm (não no mesmo dente) OU 1 local com PS ≥5 mm. Equações polinomiais de 4º grau apresentaram altos coeficientes de determinação (R²= 1) e foram utilizadas para representar os modelos matemáticos dos casos de periodontite. De acordo com a definição 1, o diagnóstico de periodontite foi preciso ao incluir no modelo: idade, sexo, escolaridade, índice de placa (IP), número de dentes perdidos, instruções de higiene anteriores e índice de massa corporal (IMC). De acordo com a definição 2, o diagnóstico de periodontite foi preciso ao incluir no modelo: idade, sexo, escolaridade, renda, IP, instruções prévias de higiene bucal, frequência de escovação e tipo de escova dental e uso de enxaguatório bucal no modelo. Para um diagnóstico preciso de periodontite de acordo com a definição 3, o modelo incluiu: idade, escolaridade, IP, número de dentes perdidos, instrução prévia de higiene oral, IMC e diabetes. Os modelos matemáticos multifatoriais foram capazes de diagnosticar a periodontite de acordo com diferentes definições de casos de periodontite usando apenas variáveis de fácil avaliação e não invasivas. (AU)

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Short dental implants with platform matching connection have been used for the rehabilitation of atrophic jaws whenever standard-length dental implants cannot be placed without prior bone augmentation. Yet, there remains a lack of data regarding the risk of technical failures when the all-on-4 configuration is performed in atrophic jaws with platform-switching distal short dental implants. Thus, the current study used the finite element method to evaluate the mechanical behavior at the level of the prosthetic components of the all-on-4 concept performed in atrophic mandible using short-length distal implants with platform switching (PSW) connection. Three models of the all-on-4 configuration were generated in human atrophic mandibles. The geometric models consisted of PSW connection tilted standard (AO4T; θ = 30 deg; 11 mm-length), straight standard (AO4S; θ = 0 deg; 11 mm-length) and straight short (AO4Sh; θ = 0 deg; 8 mm-length) distal implants. A resultant force of 300 N was performed obliquely in the left side and posterior region of the prosthetic bar. The von Mises equivalent stress (σvm) and maximum and minimum principal stresses (σmax and σmin) were performed at level of the prosthetic components/implants and peri-implant bone crest, respectively. The general displacement of the models was also evaluated. The stress analysis was performed on the side of load application. The AO4S configuration showed the lowest values of σvm in the mesial left (ML) and distal left (DL) abutments (37.53 MPa and 232.77 MPa, respectively) and dental implants (91.53 MPa and 231.21 MPa, respectively). The AO4Sh configuration showed the highest values of σvm in the bar screw (102.36 MPa), abutment (117.56 MPa), and dental implant (293.73 MPa) of the ML area. Among the models, the highest values of σmax and σmin were noticed in the peri-implant bone crest of the AO4T design (131.48 MPa and 195.31 MPa, respectively). All models showed similar values of general displacements, which were concentrated in the mandible symphysis. The all-on-4 configurations designed with PSW connection and tilted standard (AO4T; θ = 30 deg; 11 mm-length), straight standard (AO4S; θ = 0 deg; 11 mm-length) or straight short (AO4Sh; θ = 0 deg; 8 mm-length) distal implants were not associated with higher odds of technical failures. The AO4Sh design may be a promising option for the prosthetic rehabilitation of atrophic jaws.

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PURPOSE: To compare the mechanical behavior (stress load dissipation and/or concentration) of posterior crowns made from Lava Ultimate (LU; 3M ESPE) and IPS e.max CAD (LD; Ivoclar Vivadent) using finite element analysis (FEA). MATERIALS AND METHODS: A 3D model of a mandibular first molar was prepared by reducing the occlusal surface by 1 or 2 mm (according to group), the axial walls by 1.5 mm, and using a 0.8-mm-deep shoulder margin as a finish line. A convergence of 6 degrees between opposing walls was set. Subsequently, four 3D crown models were created according to two test groups with two different occlusal thicknesses: (1) LD with 1.0 mm (LD1); (2) LD with 2.0 mm (LD2); (3) LU with 1.0 mm (LU1); and (4) LU with 2.0 mm (LU2). FEA models were constructed using the software Femap (Siemens). A load of 200 N was applied in the axial and oblique (20 degrees) directions for each group, and stress dissipation was viewed using the NEi Nastran software. RESULTS: FEA results demonstrated that the LU crowns dissipated the occlusal load to the tooth structure, whereas the LD material concentrated the load inside the crowns. For the LU material, the lower the occlusal thickness, the higher the stress concentration inside the crown became, and the 2.0-mm occlusal thickness transferred lower stress to the tooth structure. The oblique, rather than the vertical, load caused an increase in the maximum stress concentration at the shoulder margin and axial walls. CONCLUSION: The higher the Young's Modulus mismatch between the crown material and substrate, the higher the load stress concentration inside the material became. The 2-mm occlusal thickness acted by decreasing the load stress to the tooth substrate. Finally, the axial load delivered more favorable stress transmission to the tooth substrate. The crown material and the occlusal thickness appear to be two factors that affect the mechanical behavior of stress dissipation to the tooth structure.

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PURPOSE: It is known that a correct transverse maxillary dimension is a key factor for a stable occlusion, which brings functional and esthetic benefits for the patient. In patients presenting maxillary atresia and the completion of bone growth, a highly recommended option for correction is the surgically assisted rapid maxillary expansion (SARME) associated with the Hyrax appliance. The objective of this study was to evaluate the influence of tooth anchorage variations of the Hyrax appliance in SARME through finite element analysis, evaluating which anchorage option might be associated with more effective orthopedic results with less undesired side effects. METHODS: Five different dental anchoring conditions for the Hyrax appliance were simulated through FE analysis applying premolars and molars as anchorage, having the same force applied by the activation of the Hyrax screw (0.5 mm) in all groups. The maxillary displacement results (axes X, Y, and Z) and generated stresses for both teeth and maxillary bone were calculated and represented using a color scale. RESULTS: All groups presented significant bone displacement and stress concentration on anchoring teeth, with the group presenting anchorage in the 1st and 2nd molars showing the greatest maxillary horizontal displacement (axis X) and suggesting the lowest tendency of dental vestibular inclination. CONCLUSIONS: Variations in dental anchorage might substantially affect the maxillary bone and teeth displacement outcome. The protocol for the Hyrax apparatus in SARME applying the 1st and 2nd molars as anchorage might generate less tilting and inclination of the anchoring teeth.

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INTRODUCTION: The success of bone-implant prostheses depends on several factors, among them an adequate distribution and passive adaptation of occlusal loading. OBJECTIVE: this study evaluated the stress distribution in mandibular implant-supported prosthesis with internal connection morse taper interface, under effect of number of implants (4 or 5) and loadings (bilateral 100 N, bilateral 300 N). MATERIALS AND METHODS: the virtual models were subjected to analysis by 3D finite element method, across four experimental conditions. RESULTS: The stress values were evenly distributed to the peri-implant bone and implants in all simulated conditions. Stress values did not increase in the same proportion as the increase in the applied load (from 100 to 300 N). The stress value was 1.1 times higher on the implants and nearly doubled (1.5-2 times) on the peri-implant bone. CONCLUSION: For mandibular implant-supported prosthesis, the morse taper interface is strongly recommended, with similar mechanical demand for four and five implants in both loading conditions. Five implants offered no additional benefit over four implants. The commercial pure titanium frameworks presented stress values close to the yield strength of the metal, especially at the intersection with the cantilever.

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INTRODUCTION: The objective of this study was to evaluate the effects of the torqued cantilever (TC) and conventional tip-back cantilever (CC) made of stainless steel (SS) and titanium-molybdenum alloy (TMA) on the uprighting of mesially impacted mandibular molars using three-dimensional finite element analysis. METHODS: The 3-dimensional mandibular model included part of the mandible with mesially tipped and impacted mandibular second molar, periodontal ligament (PDL), molar tube, mini-implant, and cantilevers. Four finite element method models (TC-SS, TC-TMA, CC-SS, and CC-TMA) were created to simulate different skeletally anchored uprighting mechanics. CC mechanics involved a known 0.019 × 0.025-in helical cantilever acting on a buccal molar tube. TC mechanics included a 0.019 × 0.025-in cantilever capable of producing mesial root torque by acting on a tube positioned on the molar disto-occlusal surface with the slot in a buccolingual direction. Three-dimensional molar displacement and stress distribution on the molar PDL were recorded. RESULTS: The SS cantilever produced almost twice as much molar displacement as the TMA. TC mechanics showed more evident mesial displacement of the molar root apexes. CC mechanics had greater molar rotation. TC uprighting moment produced greater molar mesial extrusion and greater intrusion of the distal root apex. The dual deflection system of the TC mechanics induced the lowest stress on the PDL, regardless of the metallic alloy. CONCLUSIONS: TC delivered a more efficient uprighting moment to the molar with less unwanted tooth movement and stress on the PDL and a more accessible site for bonding the molar tube.

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AIM: The aim of this study was to evaluate the stress distribution of a planned removable partial denture (RPD) using new proposals for calibrated gauges of 0.3 mm and 0.35 mm undercuts through the three-dimensional (3D) finite element methodology, and compare them with 0.25 mm and 0.5 mm gauges that are already existing in clinical practice. MATERIALS AND METHODS: Kennedy class-I edentulous 3D models and their respective RPDs (InVesalius software; Rhinoceros and SolidWorks CAD) were created and exported to the finite element program HyperMesh 2019 for mesh configuration. In the following steps, axial loading (0º) of 40 N per point was performed, with 3 points on the molars and 2 points on the premolars, totaling 280 N unilaterally. The model was processed by the OptiStruct 2019 software and imported into the HyperView 2019 software to obtain the stress maps (MPa). RESULTS: The use of 0.30 and 0.35 mm calibrated gauges presented tensions similar to those with the 0.25 mm gauge (gold standard) and caused no significant damage to biological structures. The use of a 0.5 mm undercut caused greater traction force in the periodontal ligament of the abutments. CONCLUSIONS: The 0.35 mm undercut seems promising as it presented more favorable results in this simulation, on the other hand, a 0.5 mm undercut is greater than that necessary for retainers made of CoCr. CLINICAL SIGNIFICANCE: This study aims to measure a new undercut gauge (0.35 mm) to increase the retention area in abutment teeth of removable partial dentures.

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PURPOSE: To assess the effects of tilted external hexagon implants and splinted restorations in terms of stress distribution on the bone tissue, implants, and prosthetic screws, using three-dimensional finite element analysis. MATERIALS AND METHODS: Six models were used to simulate a posterior maxilla bone block (type IV) from the first premolar to the first molar. Each model included three 4.1-mm-diameter external hexagon implants with varying inclinations (0°, 17°, and 30°) and crown designs (splinted and nonsplinted restorations). The forces applied were as follows: 400 N axially (50 N for each slope of the cusp) and 200 N obliquely (45° only on the buccal slope of the cusp). Stress distribution on the implants and prosthetic screw was evaluated using Von Mises stress, while the maximum principal stress was used to evaluate the stress distribution in the bone tissue. RESULTS: The oblique load increased the stress on all the structures in all the models. Increased inclination of the implants resulted in higher stress concentration in the bone tissue, implants, and prosthetic screws. However, splinted restorations contributed to reduction of the stress for the oblique loading, mainly in the bone tissue and prosthetic screw of the first molar, as the stress was shared between the first and second premolar restorations. CONCLUSIONS: Tilted implants increased proportionally the stress on bone tissue and prosthetic screws of models. Additionally, splinting restorations reduced the stress concentration area in the simulated bone tissue, implants, and prosthetic screws in the first molar, as the stress was shared with the adjacent implants.

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This is an in silico study aimed to evaluate the biomechanical influence of different implant-abutment interfaces (external hexagon and Morse taper implants), retention systems (cement and screw retained), and restorative crowns (metal-ceramic and monolithic) using 3-dimensional finite element analysis (3D-FEA). Eight 3D models were simulated for the maxillary first molar area using InVesalius, Rhinoceros, and SolidWorks and processed using Femap and NEi Nastran software. Axial and oblique forces of 200 and 100 N, respectively, were applied on the occlusal surface of the prostheses. Microstrain and von Mises stress maps were used to evaluate the deformation (cortical bone tissue) and stress (implants/fixation screws/crowns), respectively, for each model. For both loadings, Morse taper implants had lower microstrain values than the external hexagon implants. The retention system did not affect microstrain on the cortical bone tissue under both loadings. However, the cemented prosthesis displayed higher stress with the fixation screw than the external hexagon implants. No difference was observed between the metal-ceramic and zirconia monolithic crowns in terms of microstrain and stress distribution on the cortical bone, implants, or components. Morse taper implants can be considered as a good alternative for dental implant rehabilitation because they demonstrated better biomechanical behavior for the bone and fixation screw as compared to external hexagon implants. Cement-retained prosthesis increased the stress on the fixation screw of the external hexagon implants, thereby increasing the risk of screw loosening/fracture in the posterior maxillary area. The use of metal-ceramic or monolithic crowns did not affect the biomechanical behavior of the evaluated structures.

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OBJECTIVE: The objective of this study was to evaluate the effect of the rapid palatal expansion (RPE) on the pterygoid process (PP), spheno-occipital synchondrosis (SOS) and sella turcica (ST) in the skull of a patient with transversal maxillary collapse, and identify the distribution of mechanical stresses and displacement, by finite element analysis (FEA). METHODS: Cone-beam computed tomography (CBCT) was employed to examine the skull of a patient in this study. The patient was a 13-year-old boy, with Class II skeletal relationship due to transverse atresia and maxillary protrusion. The computer-aided design (CAD) geometry of skull was imported into the SimLab v. 13.1 software, to build the finite element mesh. For the simulation, a displacement of 1 mm, 3 mm and 5 mm in a transverse direction was defined at the midpalatal suture, thereby representing the RPE. For the analysis of results, maximum principal stress (MPS) and displacements were evaluated by identifying different nodes, which were represented by the points as per the areas of interest in the study. RESULTS: In MPS, the maximum tensile stress was found at point 2 (366.50 MPa) and point 3 (271.50 Mpa). The maximum compressive stress was found at point 8 (-5.84 Mpa). The higher displacements in the transversal plane and the lateral segment were located at point 1 (2.212 mm), point 2 (0.903 mm) and point 3 (0.238 mm). CONCLUSIONS: RPE has a direct effect on PP, SOS and ST in the Class II model skeletal relationship with a transversal maxillary collapse. PP supported a higher tensile stress and displacement.

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INTRODUCTION: This study aimed to simulate the different positions of the hyrax appliance expander screw and evaluate tooth displacement and the stress distribution standard on the periodontal ligament using the finite element method. METHODS: Part of the maxilla with anchorage teeth, periodontal ligament, midpalatal suture, and the hyrax appliance was modeled, and finite element method models were created to simulate 6 different screw positions. There were 2 vertical positions at distances of 20 mm and 15 mm from the occlusal plane. Another position was anteroposterior, the center of the screw placed between and equidistant from the mesial face of the first molar and the distal face of the first premolar, aligned to the center of the crown of the first molar, with the anterior edge of the screw aligned to the distal face of the first molar. A 1 mm activation of the expander screw was simulated. The displacement (total, vertical, and buccolingual) and the stress distribution on the periodontal ligament of supporting teeth in each model were registered. RESULTS: The model simulating the expander screw in a more occlusal and anterior position presented higher displacement values and higher stress concentration, followed by the model with the screw in a more posterior but same vertical position. With the exception of the first premolar, the teeth presented cervical-apical displacement in the vestibular face and apical-cervical displacement in palatal faces. This displacement is compatible with the vestibular inclination associated with the activation of the expander screw. The first premolar presented an atypical tendency for the mesial and lingual displacement of the vestibular surface and counterclockwise rotation. CONCLUSIONS: The supporting teeth presented a tendency for vestibular crown displacement and lingual root displacement associated with compression areas in the vestibular-cervical region and tensile strength in the linguoapical region. Placing the expander screw in a more occlusal and anterior position generated more mechanical stress transfer, resulting in greater dental displacement.

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Bone is a dynamic tissue that can always rebuild itself by modeling and remodeling to maintain functionality. This tissue is responsible for several vital functions in the body, such as providing structural support for soft tissues and the body, being the central region of hematopoiesis in human adults, and contributing to mineral homeostasis. Besides, it has an innate ability of auto-regeneration when damaged. All of these processes involve several molecular cues related to biochemical and mechanical stimulus. However, when the lesion is complicated or too big, it is necessary to intervene surgically, which may not effectively solve the problem. Bone tissue engineering seeks to provide resources to resolve these clinical issues and has been advancing in recent years, presenting promising devices for bone tissue repair. The understanding of some important biofactors and bone stem-cells influence might be crucial for an effective regenerative medicine, since bone is one of the most transplanted tissues. So, the purpose of this article is to provide an overview of the bone tissue, including the role of stem cells and some of the bioactive molecules associated with these processes. Finally, we will suggest future directions for bone tissue engineering area that might be helpful in order to produce biomimetic bone substitutes that become a real alternative to translational medicine.

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PURPOSE: This study evaluated the mechanical behavior of different configurations of the All-on-4 treatment concept designed with straight short (6-mm-length), straight standard (11-mm-length), or tilted standard (30-degree angled; 11-mm-length) posterior implants. MATERIALS AND METHODS: The All-on-4 configurations were performed in atrophic mandible models and consisted of anterior straight standard and posterior tilted standard implants (H1 model), anterior straight standard and posterior straight short implants (H2 model), and anterior and posterior straight standard implants (H3 model). Three oblique forces of 100 N were simulated in the posterior region of the prosthetic bar. The values of stress were obtained for the ductile materials using the von Mises equivalent stress (σvm) criteria. The stress peaks in the peri-implant bone crest were measured by the maximum (σmax) and minimum (σmin) principal stresses. The two-way analysis of variance (two-way ANOVA) and Tukey post hoc tests determined significant differences (P < .01) of stress values among the ductile materials (implant and prosthetic components). RESULTS: The use of tilted standard posterior implants (H1 model) showed the lowest values of σmax and σmin in the posterior region of the peri-implant bone area. On the other hand, the use of straight short (H2 model) or straight standard (H3 model) posterior implants significantly reduced the von Mises mean stresses in the bar screws, abutments, and abutment screws (P < .01). CONCLUSION: The higher odds of technical failures (screw fracture/loosening) may be expected when the All-on-4 configuration is performed with tilted standard posterior implants. Also, peri-implant bone overload may occur when the All-on-4 design is performed with straight short or straight standard posterior implants in atrophic mandibles.

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STATEMENT OF PROBLEM: A consensus regarding the biomechanical effects of vertical bone loss in normal and osteoporotic bone tissue according to different implant-abutment interfaces is lacking. PURPOSE: The purpose of this finite element analysis study was to evaluate the effect of vertical bone loss (without bone loss; with 1.5-mm bone loss; with 3-mm bone loss; and with 4.5-mm bone loss) in normal and osteoporotic bone that received a Ø4×10-mm implant with different implant-abutment connections (external connection [external hexagon] and internal connection [Morse taper]) by using 3D finite element analysis. MATERIAL AND METHODS: Sixteen 3D models were simulated. Axial and oblique forces of 200 N and 100 N, respectively, were applied on the occlusal surfaces of the prostheses. Maximum principal stress and microstrain were determined from the bone tissue of each model. von Mises stress analysis was used to evaluate the stress distribution in implants and prosthetic components (fixation screws, abutment, and crown). RESULTS: The results showed higher stress concentrations in models with bone loss as increased vertical bone loss contributed to higher stress and microstrain in the bone tissue, regardless of the quality of bone and implant-abutment connection. Osteoporotic bone contributed to increase in microstrain in the trabecular bone. The internal connection showed lower stress than the external connection implants only in models without marginal bone loss. Furthermore, higher stress concentrations were observed in the implants and fixation screws in models with increased bone loss and external connection implants, mainly under oblique loading. Osteoporotic bone did not affect stress distribution in the implants and prosthetic components. CONCLUSIONS: Progressive bone loss contributed to higher stress in the bone tissue, implants, and prosthetic components. The osteoporotic bone affects only the microstrain in the trabecular bone, but not the stress in the implants and prosthetic components. The internal connection implants showed lower stress in the cortical bone only in models without bone loss, while external connection implants exhibited higher stress in the implants and screws under oblique loading.

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This study analyzed the biomechanical behavior of rigid and nonrigid tooth-implant supported fixed partial dentures. Different implants were used to observe the load distribution over teeth, implants, and adjacent bone using three-dimensional finite element analysis. A simulation of tooth loss of the first and second right molars was created with an implant placed in the second right molar and a prepared tooth with simulated periodontal ligament (PDL) in the second right premolar. Configurations of two types of implants and their respective abutments-external hexagon (EX) and Morse taper (MT)-were transformed into a 3D format. Metal-ceramic fixed partial dentures were constructed with rigid and nonrigid connections. Mesh generation and data processing were performed on the 3D finite element analysis (FEA) results. Static loading of 50 N (premolar) and 100 N (implant) were applied. When an EX implant was used, with a rigid or nonrigid connection, there was intrusion of the tooth in the distal direction with flexion of the periodontal ligament. Tooth intrusion did not occur when the MT implant was used independent of a rigid or nonrigid connection. The rigid or nonrigid connection resulted in a higher incidence of compressive forces at the cortical bone as well as stress in the abutment/pontic area, regardless of whether EX or MT implants were used. MT implants have a superior biomechanical performance in tooth-implant supported fixed partial dentures. This prevents intrusion of the tooth independent of the connection. Both types of implants studied caused a greater tendency of compressive forces at the crestal area.

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An in silico model for the estimation of volumetric bone mineral density (vBMD) changes at a cortical bone site subjected to mechanobiological bone remodeling is proposed in this manuscript. Mechanisms of cell differentiation, receptor-ligand binding, mechanical signaling, and resorption or deposition of bone matrix were considered, therefore providing a comprehensive description of mechanobiological bone remodeling in the bone microenvironment and enabling the analysis of temporal evolution of disease or therapy scenarios. The proposed model is composed by five modules, namely, bone cells populations, mechanobiology, volume fractions and porosity, mineral density, and structural stiffness. The model is an extension of other models found in the literature because equations for the obtaining of cortical vBMD and the binding of parathyroid hormone (PTH) to parathyroid hormone 1 receptor are included. The proposed model showed a satisfactory agreement with the solutions of other in silico models found in the literature. Simulations of walking and running exercise routines were performed for the evaluation of model capability regarding the control of the numerical error and prediction of vBMD. The computational method used to solve the case study controlled the relative numerical error by less than 1 × 10-7 for approximately 1.7 × 106 time steps. The predicted values correlate with the concept of increasing BMD by vigorous physical activity; however, they contrast with the specific effect of physical activities on cortical vBMD.

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PURPOSE: To evaluate the biomechanical behaviors of different framework materials in implant-supported fixed mandibular prostheses using three-dimensional (3D) finite element analysis. MATERIALS AND METHODS: A model of a severely resorbed edentulous mandible was obtained from a tomography database. Morse taper-connection implants and multi-unit abutments were cut with an electro-erosion machine and scanned using a 3D scanner. The implants were positioned on the model at the bone level and distributed equally to support a fixed complete prosthesis. The simulations were divided into six groups according to the framework material: titanium (Ti); cobalt-chromium (Co-Cr); zirconia (ZrO2); polyether ether ketone (PEEK); carbon fiber-reinforced polyether ether ketone (CFR-PEEK); and polymethyl methacrylate (PMMA). The resultant load applied was obtained from the masseter, temporal, lateral, and medial pterygoid muscles. The principal stresses and von Mises equivalent stresses were analyzed and compared among the framework materials, and the results were described both quantitatively and qualitatively. RESULTS: PEEK and PMMA frameworks showed the highest total deformation values, showing decreases of von Mises stresses in the frameworks, implants, and abutments, but with a high tensile stress in the trabecular bone that achieved critical values. CFR-PEEK frameworks achieved their failure limit, whereas the ZrO2, Co-Cr, and Ti frameworks exhibited principal stresses in the bone region within physiologic limits. CONCLUSION: From a biomechanical point of view, the Ti, Co-Cr, and ZrO2 frameworks demonstrated the most favorable outcomes.

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