RESUMEN
Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic disease, and its clinical information and prevalence are important. This study was conducted on 22 feline patients from the Republic of Korea (ROK), suspected to suffer from a tick-borne disease. Four cats were positive for SFTS, and genotypes B-1, B-3, D, and F were identified. Clinical symptoms, such as anorexia, jaundice, thrombocytopenia, leukopenia, and hyperbilirubinemia, were detected. This is the first report of SFTS virus genotypes B-1, D, and F from cats in the ROK. Moreover, our results suggest that jaundice may be an indicator of SFTS in cats.
Asunto(s)
Infecciones por Bunyaviridae , Enfermedades de los Gatos , Phlebovirus , Síndrome de Trombocitopenia Febril Grave , Trombocitopenia , Enfermedades por Picaduras de Garrapatas , Garrapatas , Gatos , Animales , Síndrome de Trombocitopenia Febril Grave/diagnóstico , Síndrome de Trombocitopenia Febril Grave/epidemiología , Síndrome de Trombocitopenia Febril Grave/veterinaria , Infecciones por Bunyaviridae/diagnóstico , Infecciones por Bunyaviridae/epidemiología , Infecciones por Bunyaviridae/veterinaria , Mascotas , Phlebovirus/genética , Enfermedades por Picaduras de Garrapatas/diagnóstico , Enfermedades por Picaduras de Garrapatas/epidemiología , Enfermedades por Picaduras de Garrapatas/veterinaria , Trombocitopenia/veterinaria , República de Corea/epidemiología , Enfermedades de los Gatos/diagnóstico , Enfermedades de los Gatos/epidemiologíaRESUMEN
Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging zoonotic virus in East Asia. However, SFTS virus (SFTSV) has not been reported to cause clinical infection in companion dogs to date. We report the case of a 4-year-old companion dog that presented with fever, vomiting, leukocytopenia and thrombocytopenia at a veterinary hospital in the Republic of Korea. It was diagnosed with SFTS, which was confirmed using real-time reverse transcription PCR, sequencing and an indirect immunofluorescence assay, and recovered after supportive care. Further studies are required to investigate SFTSV infection in companion animals, living in close contact with humans, as well as animal-to-human transmission.
Asunto(s)
Enfermedades de los Perros/diagnóstico , Phlebovirus/aislamiento & purificación , Síndrome de Trombocitopenia Febril Grave/veterinaria , Animales , Enfermedades de los Perros/virología , Perros , Fiebre/veterinaria , Fiebre/virología , Leucopenia/veterinaria , Leucopenia/virología , Masculino , República de Corea , Síndrome de Trombocitopenia Febril Grave/diagnóstico , Síndrome de Trombocitopenia Febril Grave/virología , Trombocitopenia/veterinaria , Trombocitopenia/virología , Resultado del Tratamiento , Vómitos/veterinaria , Vómitos/virologíaRESUMEN
OBJECTIVE To determine serum cholecystokinin (CCK) concentrations in dogs with pituitary-dependent hyperadrenocorticism (PDH) and to evaluate associations among CCK concentration, PDH, and gallbladder mucocele (GBM). ANIMALS 14 client-owned dogs with PDH and 14 healthy dogs. PROCEDURES Dogs were separated into 4 groups: healthy dogs without gallbladder sludge (group A; n = 7), healthy dogs with gallbladder sludge (group B; 7), dogs with PDH and gallbladder sludge (group C; 8), and dogs with PDH and GBM (group D; 6). Serum CCK concentrations were then measured before and 1, 2, and 4 hours after consumption of a high-fat meal. Concentrations in dogs with PDH were also measured before and after trilostane treatment. Results were compared among groups and assessment points. RESULTS Preprandial serum CCK concentrations in group C were significantly lower than those in groups A, B, and D, but no significant differences in postprandial CCK concentrations were identified among the groups 1, 2, or 4 hours after the meal. With respect to trilostane treatment of dogs with PDH, no significant differences were identified between pre- and post-trilostane serum CCK concentrations in group C or D. Median CCK concentration after trilostane treatment was higher in group D than in group C, but this difference was not significant. CONCLUSIONS AND CLINICAL RELEVANCE The outcomes in this study did not support the hypothesis that a low circulating CCK concentration affects the development of GBM in dogs with PDH.
Asunto(s)
Hiperfunción de las Glándulas Suprarrenales/veterinaria , Colecistoquinina/sangre , Enfermedades de los Perros/sangre , Hiperfunción de las Glándulas Suprarrenales/sangre , Animales , Estudios de Casos y Controles , Colesterol/sangre , Dihidrotestosterona/análogos & derivados , Dihidrotestosterona/uso terapéutico , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/tratamiento farmacológico , Perros , Inhibidores Enzimáticos/uso terapéutico , Femenino , Enfermedades de la Vesícula Biliar/sangre , Enfermedades de la Vesícula Biliar/veterinaria , Hidrocortisona/sangre , MasculinoRESUMEN
An 8 wk old female Dalmatian weighing .56 kg presented with growth retardation. The puppy exhibited no abnormalities during physical examination other than significantly reduced growth compared with her littermates. Endocrine results suggested pituitary dwarfism. Two wk later, the puppy returned due to the onset of megaesophagus, but the puppy unfortunately died the following morning. This case report describes the diagnosis of dwarfism in a Dalmatian puppy that was caused by growth hormone (GH) deficiency and describes its early clinical manifestations.