RESUMEN

A new technology for nebramycin complex antibiotics isolation from non-filtered culture fluid was developed. The industrial use of the technology permitted to exclude the stage of the culture fluid filtration, to increase the yield by more than 33% and to reduce the time of the process by 1.7 times.

Asunto(s)

Antibacterianos/aislamiento & purificación , Nebramicina/aislamiento & purificación , Antibacterianos/biosíntesis , Medios de Cultivo , Fermentación , Resinas de Intercambio Iónico , Nebramicina/biosíntesis , Streptomyces/crecimiento & desarrollo , Streptomyces/metabolismo