Asunto(s)
Enfermedad de Crohn/complicaciones , Enfermedades del Íleon/diagnóstico por imagen , Perforación Intestinal/diagnóstico por imagen , Neumoperitoneo/diagnóstico por imagen , Radiografía Torácica , Posición Supina , Adulto , Enfermedad de Crohn/diagnóstico por imagen , Humanos , Enfermedades del Íleon/etiología , Perforación Intestinal/etiología , Masculino , Neumoperitoneo/etiologíaRESUMEN
Mucin-depleted foci (MDF) are considered as useful biomarkers in rat colon carcinogenesis. The purpose of the present study was to examine the mechanism(s) underlying rat colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) plus 1% Dextran Sulfate Sodium (DSS). Twelve male F344 rats were given subcutaneous injections (40mg/kg body) of DMH twice a week. They received DSS in the drinking water for 1 week after the first injection of DMH and then were maintained on tap water. The rats were sacrificed at 10 and 14 weeks after the first injection of DMH. Colon tissues were divided into 10 segments from anus to cecum (A/J) and stained with Alcian blue (AB) to identify MDF. We found that MDF and tumors were induced in the rat colon after treatment with DMH plus DSS and that the number of MDF in each segment of the colon was significantly correlated with that of tumors (p=0.006). In addition, we found that the beta-catenin protein was accumulated in cytoplasm and nuclei of MDF and the frequent beta-catenin gene mutations in the colon tumors. These results suggest that MDF is closely related to rat colon carcinogenesis induced by DMH plus DSS.
Asunto(s)
1,2-Dimetilhidrazina , Carcinógenos , Neoplasias del Colon/genética , Sulfato de Dextran/farmacología , Mutación , Lesiones Precancerosas/patología , beta Catenina/genética , Animales , Colon/patología , Neoplasias del Colon/inducido químicamente , Neoplasias del Colon/metabolismo , Dimetilhidrazinas/metabolismo , Humanos , Masculino , Metástasis de la Neoplasia , Neoplasias Experimentales/genética , Lesiones Precancerosas/genética , Ratas , Ratas Endogámicas F344RESUMEN
Polymerase chain reaction (PCR) amplification was used for detecting circulating tumor cells. However, PCR was so sensitive that it detected a very low level of mRNA with no relevance to tumor cells. We analyzed the degree of micro-tumor spread in esophageal cancer patients using quantitative PCR. Samples were collected from 28 patients and 35 controls. Real-time quantitative PCR (LightCycler) was employed for the detection of carcinoembryonic antigen (CEA) and cytokeratin 20 (CK-20). In the CEA and CK-20 mRNA assays, 7 and 3 out of 28 patients, respectively, showed higher mRNA levels in peripheral blood than the normal range based on values of controls (mean+/-2SD). Eleven out of 19, 4 out of 14, and 2 out of 5 patients showed higher CEA mRNA levels in the samples from tumor drainage vein, costal bone marrow, and thoracic duct lymph, respectively. One of the 7 patients who showed higher CEA mRNA levels in pretreatment peripheral blood is currently free from disease. These findings reveal that quantitative PCR can discriminate high levels of cancer-specific expression from low levels of illegitimate expression in blood. They also suggest that the identification of circulating tumor cells by the CEA mRNA assay is a reliable means of predicting early recurrence.
Asunto(s)
Carcinoma de Células Escamosas/sangre , Neoplasias Esofágicas/sangre , Células Neoplásicas Circulantes , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa/métodos , Anciano , Anciano de 80 o más Años , Antígeno Carcinoembrionario/sangre , Carcinoma de Células Escamosas/diagnóstico , ADN Complementario/metabolismo , Neoplasias Esofágicas/diagnóstico , Femenino , Humanos , Proteínas de Filamentos Intermediarios/sangre , Queratina-20 , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , ARN Mensajero/metabolismo , Recurrencia , Sensibilidad y EspecificidadRESUMEN
The role of cervical lymphadenectomy for thoracic esophageal cancer is controversial. This study evaluated the impact of cervical lymphadenectomy on the cervical lymph node metastasis (LNM) and survival rates of patients with esophageal cancer. We analyzed 199 patients who received radical esophagectomy with three-field lymphadenectomy. The overall 5-year survival rate was 49.4%. Cervical LNM was found in 36 (18.1%) out of the 199 patients. The 5-year survival rates of the patients with cervical LNM from upper and mid-esophageal cancers were 71.4% and 35.9%, respectively. However, none of the patients with cervical LNM from lower esophageal cancer survived more than 4 years after esophagectomy. The overall survival of patients with five or more metastatic nodes (5.9%) was significantly worse than that of patients with less than five positive nodes (45.5%). Cervical lymphadenectomy is beneficial for patients with carcinoma of the upper and mid-thoracic esophagus, and with less than five positive nodes.
Asunto(s)
Neoplasias Esofágicas/mortalidad , Neoplasias Esofágicas/terapia , Escisión del Ganglio Linfático/métodos , Ganglios Linfáticos/patología , Ganglios Linfáticos/cirugía , Adulto , Anciano , Biopsia con Aguja , Estudios de Casos y Controles , Quimioterapia Adyuvante , Terapia Combinada , Neoplasias Esofágicas/patología , Esofagectomía/métodos , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Cuello , Estadificación de Neoplasias , Probabilidad , Radioterapia Adyuvante , Valores de Referencia , Estudios Retrospectivos , Medición de Riesgo , Estadísticas no Paramétricas , Análisis de Supervivencia , Resultado del TratamientoRESUMEN
BACKGROUND: The number of positive lymph nodes is an important prognostic predictor in patients with oesophageal cancer. However, the significance of nodal micrometastasis in patients with overt nodal metastasis is unknown. The aim of this study was to clarify the clinical implications of nodal micrometastasis in patients undergoing curative oesophagectomy for oesophageal cancer. METHODS: Cervical, mediastinal and abdominal lymph nodes systematically removed from 104 patients with oesophageal cancer were examined immunohistochemically to detect cells that stained positively for cytokeratins with the monoclonal antibody cocktail AE1/AE3. The postoperative course and survival rates were compared among patients with and without micrometastases, after numerical classification of overt metastatic nodes (none, between one and four, five or more). RESULTS: Univariate analysis showed T stage, nodal micrometastasis and number of overt nodal metastases to be significant prognostic factors after oesophagectomy. Multivariate analysis revealed nodal micrometastasis and number of overt nodal metastases to be independent prognostic factors. The presence of micrometastases had a significant adverse effect on postoperative survival in patients with no overt metastasis and in patients with one to four overt metastatic nodes, but no such impact in patients with five or more overt metastatic nodes. CONCLUSION: Assessment of nodal status by both histological examination for overt metastases and immunohistochemical examination for micrometastases is useful in stratifying patients undergoing curative oesophagectomy.
Asunto(s)
Carcinoma de Células Escamosas/cirugía , Neoplasias Esofágicas/cirugía , Esofagectomía/métodos , Adulto , Anciano , Carcinoma de Células Escamosas/patología , Supervivencia sin Enfermedad , Neoplasias Esofágicas/patología , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Escisión del Ganglio Linfático/métodos , Metástasis Linfática , Masculino , Persona de Mediana Edad , Recurrencia Local de NeoplasiaRESUMEN
The initial presentation of a patient with Wegener's granulomatosis was indistinguishable from that of Henoch-Schönlein purpura. The patient presented with skin purpura and pulmonary hemorrhage followed by purpura in the colon. The diagnosis of this patient at that time was Henoch-Schönlein purpura. With time, massive lesions in the sinus and those with cavities in the lung became apparent, and a specimen obtained from the sinus massive lesion was disclosed to be granulomatous inflammation. Retrospectively, the proteinase 3 antineutrophil cytoplasmic antibody turned out to be strongly positive in her stored serum from the time of the initial presentation.
Asunto(s)
Anticuerpos Anticitoplasma de Neutrófilos/sangre , Granulomatosis con Poliangitis/diagnóstico , Vasculitis por IgA/diagnóstico , Adulto , Autoantígenos/sangre , Diagnóstico Diferencial , Femenino , Granulomatosis con Poliangitis/inmunología , Humanos , Mieloblastina , Peroxidasa/inmunología , Serina Endopeptidasas/inmunología , Factores de TiempoRESUMEN
Esophageal perforation is potentially lethal if untreated. We report a case of distal esophageal perforation probably caused by swallowing a fish bone. The patient initially received conservative treatment 4 days after the esophageal injury. The treatment was promptly changed from conservative to operative treatment owing to rapid manifestation of suppurative mediastinitis followed by peritonitis. The patient successfully underwent primary repair of the perforation buttressed with a pedicled omental graft pulled up through the esophageal hiatus following a laparotomy. We discuss the validity of this method of transhiatal approach without thoracotomy for primary repair of distal esophageal perforation.
Asunto(s)
Perforación del Esófago/cirugía , Cuerpos Extraños/complicaciones , Mediastinitis/cirugía , Epiplón/trasplante , Anciano , Animales , Huesos , Perforación del Esófago/diagnóstico por imagen , Perforación del Esófago/etiología , Humanos , Masculino , Mediastinitis/diagnóstico por imagen , Mediastinitis/etiología , Cuidados Posoperatorios , Radiografía , Toracotomía/métodosRESUMEN
Localization of neuropeptide Y (NPY) mRNA in the hypothalamus of chickens was studied by in situ hybridization with digoxigenin-labeled chicken NPY cRNA probe. The largest number of perikarya-expressing NPY mRNA was found within the mediobasal hypothalamus, including the infundibular nucleus, inferior hypothalamic nucleus, and median eminence. Many NPY perikarya were noted to surround the nucleus rotundus and to be present in the supraoptic nucleus. Moreover, some perikarya were detected in the nucleus of basal optic root, bed nucleus pallial commissure, and nucleus striae terminalis close to the lateral forebrain bundle. NPY-immunoreactive nerve fibers were densely distributed in these regions containing the NPY mRNA-expressing perikarya. Following food deprivation for four days, perikarya-expressing NPY mRNA and peptide were markedly increased in the mediobasal hypothalamus and particularly so in the infundibular nucleus. No changes, however, were detected in other regions containing NPY-positive perikarya. Water deprivation induced less increase in NPY-positive perikarya in the mediobasal hypothalamus compared to food deprivation. After gonadectomy, the number of NPY-positive perikarya in the mediobasal hypothalamus was unaltered. Northern blot analysis with (32)P-labeled chicken NPY cDNA probe demonstrated that a 2.7-fold increase of NPY mRNA was induced by starvation and a 1.5-fold increase was induced by dehydration, whereas the NPY mRNA band remained unchanged after gonadectomy. Thus, it seems that NPY neurons located in the mediobasal hypothalamus are involved in feeding behavior but not reproductive activity.
Asunto(s)
Pollos/fisiología , Deshidratación/patología , Privación de Alimentos/fisiología , Hipotálamo/anatomía & histología , Hipotálamo/metabolismo , Neuropéptido Y/biosíntesis , Orquiectomía , ARN Mensajero/metabolismo , Animales , Northern Blotting , Hipotálamo/citología , Procesamiento de Imagen Asistido por Computador , Inmunohistoquímica , Hibridación in Situ , MasculinoRESUMEN
A 38-year-old woman visited our hospital with edema on her face and conjunctivae. The underlying disease was not clarified, and she did not visit the hospital afterwards. She suffered from diarrhea, polyarthralgia, Raynaud's phenomenon, malar rash and hair loss in the subsequent two years, and was hospitalized because of hypoproteinemia. Her urine, liver and heart test results did not account for her hypoproteinemia. She was diagnosed as having protein-losing enteropathy (PLE) associated with SLE based on the 99mtechnetium-labeled human serum albumin scintigraphy findings, clinical findings and laboratory results of antinuclear and anti-Sm antibodies. This case report demonstrates a strong association between PLE and SLE because PLE was aggravated along with the appearance of SLE symptoms and PLE subsided with prednisolone treatment along with improvement of SLE.
Asunto(s)
Lupus Eritematoso Sistémico/complicaciones , Enteropatías Perdedoras de Proteínas/etiología , Enteropatías Perdedoras de Proteínas/fisiopatología , Ribonucleoproteínas Nucleares Pequeñas , Adulto , Anticuerpos Antinucleares/análisis , Autoanticuerpos/análisis , Autoantígenos/inmunología , Femenino , Glucocorticoides/uso terapéutico , Humanos , Lupus Eritematoso Sistémico/diagnóstico por imagen , Lupus Eritematoso Sistémico/tratamiento farmacológico , Prednisolona/uso terapéutico , Enteropatías Perdedoras de Proteínas/diagnóstico por imagen , Enteropatías Perdedoras de Proteínas/tratamiento farmacológico , Cintigrafía , Radiofármacos , Ribonucleoproteína Nuclear Pequeña U1/inmunología , Albúmina Sérica/análisis , Índice de Severidad de la Enfermedad , Agregado de Albúmina Marcado con Tecnecio Tc 99m , Proteínas Nucleares snRNPRESUMEN
The effect of different photoperiods on the specific secretory cells of the pars tuberalis was examined in male chicks. Animals were placed in one of three different photoperiod regimens: (1) normal control (light:dark = 12 h:12 h), (2) continuous light (L:D = 24 h:0), and (3) extended darkness (L:D = 1 h:23 h). The levels of common alpha-subunit mRNA in the pars tuberalis were examined by Northern blot analysis and compared with those in the pars distalis. In chicks exposed to continuous light for 1 week, alpha-subunit mRNA level in the pars tuberalis was decreased, although the level in the pars distalis was increased. Exposure to continuous light for 30 days also induced a decrease in alpha-subunit mRNA level in the pars tuberalis. On the other hand, in chicks exposed to extended darkness for 1 week, the alpha-subunit mRNA level of the pars tuberalis was markedly increased. In situ hybridization with digoxigenin-labeled common alpha-subunit cRNA probe also showed that the hybridization signals for alpha-subunit mRNA in the pars tuberalis cells become weak under continuous light for 30 days but they are very intense under extended darkness. Thus, the synthesis of alpha-subunits in the chick pars tuberalis was inhibited by continuous light but stimulated by extended darkness. These results were confirmed by semiquantitative electron-microscopic analyses. After exposure to continuous light for 30 days, many pars tuberalis (PT)-specific cells were filled with enlarged secretory granules, showing the reduction of secretory activity. On the contrary, extended darkness for 30 days induced hypertrophy of the PT-specific cells; the areas of cytoplasm and nucleus were significantly increased. In addition, secretory granules became small in size and exocytotic features were more frequent. Mitochondria and lysosomes were also increased in number. Thus, the synthetic and secretory activities of the PT-specific cells were increased under extended darkness. The data indicate that the specific cells of the pars tuberalis are responsive to photoperiodic changes in the chick.
Asunto(s)
Gránulos Citoplasmáticos/ultraestructura , Fotoperiodo , Adenohipófisis/metabolismo , Adenohipófisis/ultraestructura , ARN Mensajero/metabolismo , Animales , Animales Recién Nacidos , Northern Blotting , Peso Corporal , Pollos , Gránulos Citoplasmáticos/metabolismo , Procesamiento de Imagen Asistido por Computador , Inmunohistoquímica , Hibridación in Situ , Hormona Luteinizante , Masculino , Microscopía Electrónica , Tamaño de los Órganos , Testículo/fisiología , Factores de TiempoRESUMEN
BACKGROUND: Currently, there is only limited information regarding tumor angiogenesis and its clinical implications in cases of esophageal carcinoma. The purpose of this study was to clarify which clinicopathologic parameters correlate with tumor angiogenesis; furthermore, the study was conducted to evaluate whether tumor angiogenesis is an independent prognostic factor in cases of esophageal carcinoma. METHODS: Intratumoral microvessel density (MVD) and thymidine phosphorylase (dThdPase) expression were immunohistochemically studied after extended radical esophagectomy in 103 cases of esophageal carcinoma. RESULTS: Increased MVD significantly correlated with the depth of tumor invasion, the frequency of intramural metastasis, and the stage of tumor advancement (P <.05). dThdPase expression status significantly correlated with the size and depth of primary tumors (P <.02). A significant correlation was present between MVD and the expression status of dThdPase (P <.01). Furthermore, increased MVD correlated with increased tumor recurrence after esophagectomy and with poorer survival curves (P <.01 and P <.05, respectively). A multivariate analysis revealed MVD to be an independent predictor of unfavorable prognosis. CONCLUSIONS: Tumor angiogenesis expressed as MVD correlates with clinicopathologic parameters regarding tumor progression and is an independent prognostic indicator in patients undergoing extended radical esophagectomy for invasive esophageal carcinoma.
Asunto(s)
Carcinoma de Células Escamosas/irrigación sanguínea , Carcinoma de Células Escamosas/cirugía , Neoplasias Esofágicas/irrigación sanguínea , Neoplasias Esofágicas/cirugía , Esofagectomía , Neovascularización Patológica , Adulto , Anciano , Vasos Sanguíneos/patología , Carcinoma de Células Escamosas/enzimología , Neoplasias Esofágicas/enzimología , Humanos , Microcirculación , Persona de Mediana Edad , Invasividad Neoplásica , Periodo Posoperatorio , Pronóstico , Análisis de Supervivencia , Timidina Fosforilasa/metabolismo , Resultado del TratamientoAsunto(s)
Enfermedades del Sistema Nervioso Central/etiología , Enfermedad Mixta del Tejido Conjuntivo , Enfermedades del Sistema Nervioso Periférico/etiología , Enfermedades del Sistema Nervioso Central/fisiopatología , Diagnóstico Diferencial , Humanos , Meningitis Aséptica/etiología , Meningitis Aséptica/fisiopatología , Enfermedad Mixta del Tejido Conjuntivo/complicaciones , Enfermedad Mixta del Tejido Conjuntivo/fisiopatología , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Pronóstico , Enfermedades del Nervio Trigémino/etiología , Enfermedades del Nervio Trigémino/fisiopatologíaRESUMEN
The presence of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCAs) and that of antibodies against cathepsin G, a target antigen for P-ANCAs, was determined in the sera of patients with ulcerative colitis (UC), relative to the endoscopic severity and disease activity. P-ANCAs were detected by indirect immunofluorescent assay (IIF) on ethanol-fixed human neutrophils. Antibodies to cathepsin G were detected by an enzyme-linked immunosorbent assay (ELISA) and Western blotting. P-ANCAs were detected by IIF in 62.5% of 32 patients with active UC. Anti-cathepsin G antibodies were detected in 40.6% of 32 patients with active UC, and their prevalence was significantly higher in patients with severe colitis, as determined by endoscopy, than in those with mild or moderate colitis (P < 0.05). The prevalence and titers of anti-cathepsin G antibodies were significantly higher during the active than the inactive phase of the disease (P < 0.05). Measurement of titers of anti-cathepsin G antibodies by ELISA in the serum is useful for evaluating the activity of UC.
Asunto(s)
Anticuerpos Anticitoplasma de Neutrófilos/sangre , Autoanticuerpos/sangre , Catepsinas/inmunología , Colitis Ulcerosa/inmunología , Adolescente , Adulto , Anciano , Western Blotting , Catepsina G , Catepsinas/metabolismo , Colitis Ulcerosa/sangre , Colitis Ulcerosa/clasificación , Ensayo de Inmunoadsorción Enzimática , Femenino , Técnica del Anticuerpo Fluorescente Indirecta , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Serina Endopeptidasas , Índice de Severidad de la EnfermedadRESUMEN
Papillary adenocarcinoma is extremely rare in the squamous epithelium-lined esophagus. The histopathologic and immunohistochemical characteristics were examined in a composite tumor showing distinct papillary adenocarcinoma and squamous cell carcinoma of the esophagus resected from a 66-year-old man. The esophageal tumor consisted both grossly and histologically of two distinct components: an ulcerative part showing a squamous cell carcinoma, and a polypoid part corresponding to a papillary adenocarcinoma. In addition, the in situ squamous cell carcinoma was contiguous with the esophageal tumor. Mucin secretion was found only in the papillary adenocarcinoma component. Immunohistochemically, tumor cells of the papillary adenocarcinoma component were positive for carcinoembryonic antigen, secretory component, and lactoferrin. These staining patterns were similar to those of the normal esophageal gland proper. These histologic, mucin-histochemical, and immunohistochemical findings suggest that the papillary adenocarcinoma originated from the submucosal esophageal gland and the squamous cell carcinoma from the squamous epithelium lining the esophagus.
Asunto(s)
Adenocarcinoma Papilar/patología , Carcinoma de Células Escamosas/patología , Neoplasias Esofágicas/patología , Adenocarcinoma Papilar/metabolismo , Adenocarcinoma Papilar/cirugía , Anciano , Antígeno Carcinoembrionario/metabolismo , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/cirugía , Neoplasias Esofágicas/metabolismo , Neoplasias Esofágicas/cirugía , Humanos , Inmunohistoquímica , Lactoferrina/metabolismo , Masculino , Mucinas/metabolismo , Componente Secretorio/metabolismoRESUMEN
Nearly all mucosal surfaces participate in a common mucosal immune system, and application of an antigen to one mucosal surface elicits local as well as distant mucosal immune responses. However, whether the gastric mucosa is a part of this network has not been examined directly. We show here that the injection of plasmid DNA encoding beta-galactosidase into the gastric wall caused transfection of gastric mucosal epithelial cells, induced systemic and mucosal antibody responses at both local (digestive tract) and distant (genital and respiratory tracts) sites, and induced cytotoxic T lymphocyte responses in the spleen and the mesenteric and iliac lymph nodes.
Asunto(s)
Mucosa Gástrica/inmunología , Inmunidad Mucosa/inmunología , Inmunoglobulinas/sangre , Plásmidos/administración & dosificación , Linfocitos T Citotóxicos/inmunología , Vacunas de ADN/inmunología , Animales , Antígenos/genética , Antígenos/inmunología , Antígenos/metabolismo , Líquido del Lavado Bronquioalveolar/inmunología , Células Epiteliales/inmunología , Células Epiteliales/metabolismo , Heces/química , Femenino , Mucosa Gástrica/citología , Mucosa Gástrica/metabolismo , Expresión Génica , Inmunoglobulinas/análisis , Inmunoglobulinas/inmunología , Hígado/metabolismo , Ganglios Linfáticos/inmunología , Ganglios Linfáticos/metabolismo , Ratones , Ratones Endogámicos BALB C , Plásmidos/genética , Bazo/inmunología , Bazo/metabolismo , Vacunas de ADN/administración & dosificación , Vacunas de ADN/genética , Vagina/inmunología , beta-Galactosidasa/genética , beta-Galactosidasa/inmunología , beta-Galactosidasa/metabolismoRESUMEN
BACKGROUND: We examined the prevalence, patterns, and clinical significance of nodal micrometastases in patients with esophageal cancer. METHODS: Cervical, mediastinal, and abdominal lymph nodes systematically removed from 37 patients without conventional histologic evidence of lymph node metastasis from esophageal squamous cell carcinoma were immunohistochemically examined to detect cells that were stained for cytokeratins by the monoclonal antibody cocktail AE1/AE3. Postoperative care and survival were compared in cases with and without such micrometastases. RESULTS: Nodal micrometastases were found in 14 of 37 patients (38%). Among these patients, 9, 7, and 4 had micrometastases to abdominal, mediastinal, and cervical lymph nodes, respectively. Postoperative tumor recurrence was significantly more frequent in patients with micrometastases (50%) than in those without (9%, P = .008). Overall and relapse-free survival in the former group was significantly worse than in the latter group (P = .042 and P = .002, respectively). Nodal micrometastases had an independent prognostic importance for relapse-free survival as determined by multivariate analysis. CONCLUSIONS: Metastatic tumor cells are frequently present in lymph nodes, even in patients without histologic evidence of nodal metastasis from esophageal cancer. Nodal micrometastases indicates a poorer prognosis after a curative esophagectomy procedure in histologically node-negative cases.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Esofágicas/patología , Ganglios Linfáticos/patología , Metástasis Linfática , Anciano , Carcinoma de Células Escamosas/metabolismo , Carcinoma de Células Escamosas/secundario , Carcinoma de Células Escamosas/cirugía , Femenino , Humanos , Inmunohistoquímica , Queratinas/metabolismo , Escisión del Ganglio Linfático , Ganglios Linfáticos/metabolismo , Ganglios Linfáticos/cirugía , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Pronóstico , Análisis de SupervivenciaRESUMEN
An 18-year-old woman was admitted to the medical center near her home with complaints of high fever and severe headache in June 1995. A diagnosis of adult-onset Still's disease was suspected and 50 mg/day of prednisolone was orally administered. In early April 1997, the patient suffered from sudden bilateral hearing loss and high fever. Pure tone audiogram taken at the same time showed an asymmetric bilateral neurosensorial hearing loss. A diagnosis of Cogan's syndrome was made. Administration of 60 mg prednisolone daily improved fever. Audiogram taken one month after administration of prednisolone showed improvement in the right ear. Monthly cyclophosphamide pulse therapy 700 mg combined with oral prednisolone was instituted. This combination therapy enabled the successful tapering of prednisolone without recurrence of hearing loss. Combined corticosteroid and pulse cyclophosphamide therapy would appear to be one effective regimen for Cogan's syndrome.
Asunto(s)
Corticoesteroides/administración & dosificación , Ciclofosfamida/administración & dosificación , Pérdida Auditiva Sensorineural/tratamiento farmacológico , Queratitis/tratamiento farmacológico , Adolescente , Quimioterapia Combinada , Femenino , Humanos , SíndromeRESUMEN
To explore the possible histogenesis of superficially spreading carcinoma of the esophagus, the clinicopathological features of these tumors (n = 44) were compared with those of ordinary superficial carcinoma (n = 163). Tumors of a heterogeneous histological type and having in situ carcinoma components were significantly more common (P < .05), and the number of residual squamous islands was significantly greater (P < 0.05) in the former group than the latter. Furthermore, the tumor size was not different among in situ, intramucosal, and submucosal carcinomas of the former, whereas the tumors became larger according to the depth of invasion in the latter group. These results indicate that the collision of multiple simultaneously developing superficial tumors is a plausible histogenesis of superficially spreading carcinoma of the esophagus.