RESUMEN

A simple method had been developed through O-chitosan quaternary ammonium salt (O-HACC), polyvinyl alcohol (PVA) and graphene oxide (GO) to prepare O-HACC/PVA/GO dual self-healing bacteriostatic hydrogels. Then the hydrogels and materials were characterized by FT-IR, X-RD, 1H NMR, SEM and TG. The hydrogel's compressive strength, equilibrium swelling and bacteriostatic efficiency were systematically studied. The research results showed that the maximum equilibrium swelling rate of hydrogel was 720%, the maximum compressive strength was 1500 Pa, and could self-heal within 12 h. In addition, the hydrogel could effectively inhibit E. coli and S. aureus, and also showed a good release behavior for bovine serum albumin (BSA). The CCK-8 method proved that the hydrogel was non-toxic to murine fibroblasts and could promote cell proliferation and growth to a certain extent. This research has potential significance for the application of self-healing hydrogel materials in the field of biomedicine.

Asunto(s)

Quitosano , Alcohol Polivinílico , Animales , Quitosano/química , Quitosano/farmacología , Escherichia coli , Grafito , Hidrogeles/química , Hidrogeles/farmacología , Ratones , Alcohol Polivinílico/química , Compuestos de Amonio Cuaternario/química , Compuestos de Amonio Cuaternario/farmacología , Espectroscopía Infrarroja por Transformada de Fourier , Staphylococcus aureus

RESUMEN

A facile, environmentally benign approach had been developed for the preparation of dual self-healing and adsorption hydrogel through hydroxypropyl chitosan (HPCS), polyacrylamide (PAM) and polyvinyl alcohol (PVA). The self-healing capability of the hydrogels without any external stimulus was ascribed to dynamic Schiff-base bonds, borate bonds and hydrogen bonds, while the adsorption capacity of hydrogels came from the protonated amino group effect at a specific pH. It was demonstrated that the HPP DN hydrogel had a maximum equilibrium swelling ratio of 643% and a maximum compressive strength of 267 kPa. The weight loss of HPP DN hydrogel was 14.26% lower than that of HPCS/PAM single network hydrogel, furthermore, HPP DN hydrogel could achieve self-healing within 10 h. Due to the large number of active groups, the adsorption capacity of Cr6+ reached 95.31 mg/g. It could adsorb in a wide pH range of 1 to 6, and could describe by pseudo-first-order kinetic model and Langmuir adsorption isotherm model, which would provide a new idea for the adsorption and removal of heavy metal ions. In short, the prepared HPP hydrogel had dual self-healing ability, adsorption capacity and mechanical strength, which would make it a promising candidate for long-life adsorbent.

Asunto(s)

Quitosano/química , Cromo/aislamiento & purificación , Hidrogeles/química , Resinas Acrílicas , Adsorción , Celulosa/análogos & derivados , Celulosa/química , China , Cromo/química , Concentración de Iones de Hidrógeno , Iones , Cinética , Metales Pesados , Alcohol Polivinílico/química , Espectroscopía Infrarroja por Transformada de Fourier/métodos , Contaminantes Químicos del Agua/química , Purificación del Agua

RESUMEN

OBJECTIVE: To study the effects of hemostasis, analgesic and anti inflammation of the alcohol extract of Hibiscus tiliaceus and offer pharmacological and experimental basis for its safe and effective use in clinic. METHODS: The effects of hemostasist were observed with tail breaking method, capillary tube method and slide method; Hot board and body distortion induced by acetic acid methods were applied in mice analgesia experiment, the mice model of acute auricle swelling induced by dmi ethylbenzene and capillary permeability induced by acetic acid were applied to observe the anti inflammatory effects. RESULTS: The alcohol extract of Hibiscus tiliaceus could significantly reduce the bleeding time and the clotting time, delay the plant reaction time and reduce the writhing times of the mice, and it also had effect on inhibiting swelling of mice ear and the permeability of the capillary. CONCLUSION: These results suggest that the alcohol extract of Hibiscus tiliaceus has the effects of hemostasis, analgesic and anti inflammation.

Asunto(s)

Analgésicos/farmacología , Antiinflamatorios no Esteroideos/farmacología , Hemostáticos/farmacología , Hibiscus/química , Extractos Vegetales/farmacología , Analgésicos/administración & dosificación , Analgésicos/aislamiento & purificación , Animales , Antiinflamatorios no Esteroideos/administración & dosificación , Antiinflamatorios no Esteroideos/aislamiento & purificación , Conducta Animal/efectos de los fármacos , Permeabilidad Capilar/efectos de los fármacos , Modelos Animales de Enfermedad , Edema/inducido químicamente , Edema/tratamiento farmacológico , Etanol , Hemostáticos/administración & dosificación , Hemostáticos/aislamiento & purificación , Ratones , Ratones Endogámicos , Dolor/inducido químicamente , Dolor/tratamiento farmacológico , Dimensión del Dolor , Extractos Vegetales/administración & dosificación , Extractos Vegetales/aislamiento & purificación , Hojas de la Planta/química , Tallos de la Planta/química , Distribución Aleatoria , Xilenos/efectos adversos

RESUMEN

OBJECTIVE: To develop an HPLC method for content determination of protocatechuic acid, chlorogenic acid and caffeic acid in Zhuang medicine Blumea megacephala (Randeria), and explore the content variation of the 3 components of the herbs harvesting in different months, and provide the scientific basis of reasonable application. METHOD: The determination was carried out on a Shimadzu VP-ODS column (4.6 mm x 250 mm, 5 microm) eluted with acetonitrile and water containing 0.1% phosphoric acid in a linear gradient elution. The flow rate was 1 mL min(-1), and the detected wavelength was set at 258, 327nm. RESULT: The peak areas and the concentrations of the three components had good linear relationship in the range of 1.7-17 mg x L(-1) for protocatechuic acid, 15.6-156 mg x L(-1) for chlorogenic acid, 3.96-39.6 mg x L(-1) for caffeic acid. The average recoveries were 103.4%, 102.2%, 98.5%, respectively. CONCLUSION: The method was proved to be simple, accurate and used for the quality evaluation of Blumea megacephala (Randeria).

Asunto(s)

Asteraceae/química , Ácidos Cafeicos/química , Ácido Clorogénico/química , Cromatografía Líquida de Alta Presión/métodos , Hidroxibenzoatos/química , Medicamentos Herbarios Chinos/química , Plantas Medicinales/química

RESUMEN

In the title compound, C(27)H(21)N(3)O(2)·2H(2)O, the three benzene rings attached to the heterocyclic imidazole ring are not coplanar with the latter, making dihedral angles of 14.8 (2), 31.4 (2), and 37.5 (2)°, respectively, for the benzene ring planes in the 2-, 4- and 5-positions. In the crystal, there are two water mol-ecules which serve as connectors between the acrylate mol-ecules and stabilize the structure via N-H⋯O, O-H⋯N, C-H⋯O and O-H⋯O hydrogen bonding.