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13.
Artículo en Rumano | MEDLINE | ID: mdl-128101

RESUMEN

The present paper deals with the conditions that influenza vaccines must comply with, their efficiency in terms of the route of administration, the major antigenic changes of influenza viruses, that has to be known from beforehand, a basic problem for the efficient control of a pandemic. Vaccination must have in view reduction of the mortality and morbidity rate, a major criterion in establishing a programme for the prevention of influenza by vaccination.


Asunto(s)
Vacunas contra la Influenza , Gripe Humana/prevención & control , Adolescente , Adulto , Antígenos Virales/análisis , Niño , Preescolar , Humanos , Lactante , Vacunas contra la Influenza/normas , Rumanía , Vacunación
14.
Artículo en Rumano | MEDLINE | ID: mdl-128105

RESUMEN

The distribution per age groups of antibodies to influenza viruses A/Hong Kong/1/68, A/England/837/69 and A/England/42/72 in the sera collected in 1970 demonstrates that antigenically similar strains also dominated the epidemiologic picture of influenza in the past century. The results suggest that the pandemic of 1893 and infection in persons born before 1885 were caused by a strain similar to A/Hong Kong/1/68 and in those born in 1895-1897 by the antigenic variant A/England/42/72. The anamnestic response to the A/England/69 variant, following upon vaccination with the Hong Kong strain shows that the primary infection in persons born before 1900 was caused by a strain antigenically similar to the first variant. The data obtained lend support to the hypothesis of antigenic recycling of influenza virus and of the finite character of the antigenic variation of influenza viruses.


Asunto(s)
Gripe Humana/inmunología , Orthomyxoviridae , Factores de Edad , Anciano , Anticuerpos Antivirales/análisis , Antígenos Virales/análisis , Humanos , Virus de la Influenza A , Persona de Mediana Edad
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