RESUMEN
Benzofuro[6,7-d]thiazoles, benzofuro[7,6-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species and Cryptococcus neoformans. Among them tested, many of synthesized compounds showed potent antifungal activity. The compounds 4d, 6e and 6h completely inhibited the growth of all Candida and Aspergillus species tested at the MIC level of 6.3 µg/mL. The results suggest that benzofuro[6,7-d]thiazoles and 6-arylaminobenzo[d]thiazole-4,7-diones would be promising antifungal agents.
Asunto(s)
Antifúngicos/síntesis química , Benzofuranos/química , Tiazoles/química , Antifúngicos/química , Antifúngicos/farmacología , Aspergillus/efectos de los fármacos , Candida/efectos de los fármacos , Cryptococcus neoformans/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Tiazoles/síntesis química , Tiazoles/farmacologíaRESUMEN
Furo[2,3-f]quinolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida,Aspergillus species, and Cryptococcus neoformans. Among them tested, many furo[2,3-f]quinolin-5-ols showed good antifungal activity. The results suggest that furo[2,3-f]quinolin-5-ols would be promising antifungal agents.
Asunto(s)
Antifúngicos/síntesis química , Hidroxiquinolinas/química , Antifúngicos/química , Antifúngicos/farmacología , Aspergillus/efectos de los fármacos , Candida/efectos de los fármacos , Hidroxiquinolinas/metabolismo , Hidroxiquinolinas/farmacocinética , Pruebas de Sensibilidad Microbiana , Relación Estructura-ActividadRESUMEN
1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents.
Asunto(s)
Antifúngicos/síntesis química , Indoles/síntesis química , Quinolinas/síntesis química , Animales , Antifúngicos/farmacología , Hongos/efectos de los fármacos , Indoles/farmacología , Quinolinas/farmacología , Relación Estructura-ActividadRESUMEN
6-Arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among those tested, many compounds showed good antifungal activity. The results suggest that phthalazine-5,8-diones would be potent antifungal agents.
Asunto(s)
Antifúngicos/síntesis química , Química Farmacéutica/métodos , Ftalazinas/química , Ftalazinas/síntesis química , Antifúngicos/farmacología , Candida/metabolismo , Candida albicans/metabolismo , Diseño de Fármacos , Concentración 50 Inhibidora , Pruebas de Sensibilidad Microbiana , Modelos Químicos , Conformación Molecular , Estructura Molecular , Relación Estructura-ActividadRESUMEN
1H-Indole-4,7-diones were synthesized and tested for in vitro antifungal activity against fungi. The synthesized 1H-indole-4,7-diones generally showed good antifungal activity against Candida krusei, Cryptococcus neoformans, and Aspergillus niger. The results suggest that 1H-indole-4,7-diones would be potent antifungal agents.