RESUMEN

A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.

Asunto(s)

Infecciones del Sistema Nervioso Central/virología , Infecciones por Circoviridae/epidemiología , Circoviridae/genética , Adulto , Secuencia de Bases , Infecciones del Sistema Nervioso Central/líquido cefalorraquídeo , Infecciones del Sistema Nervioso Central/epidemiología , Niño , Circoviridae/clasificación , Circoviridae/aislamiento & purificación , Infecciones por Circoviridae/líquido cefalorraquídeo , Infecciones por Circoviridae/virología , ADN Viral/genética , Femenino , Variación Genética , Genoma Viral , Geografía , Humanos , Malaui/epidemiología , Masculino , Datos de Secuencia Molecular , Alineación de Secuencia , Análisis de Secuencia de ADN , Vietnam/epidemiología