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OBJECTIVES: Candida spp. is an opportunistic pathogen that causes superficial and invasive infections with nosocomial outbreaks without strict hygiene protocols. Herein, we assessed oral colonisation by Candida spp. in 209 Intensive Care Unit (ICU) patients between July 2021 and April 2022, conducting clinical, epidemiological, and microbiological characterisation of those developing oral or invasive candidiasis. METHODS: Initial oral swabs were collected within 24 h of admission in the ICU, followed by collections on Days 2, 4, 6 and 8. Swabs from denture-wearing patients, abiotic surfaces, healthcare professionals' hands, and retroauricular regions were also obtained. Recovered yeasts and filamentous fungi were identified using MALDI-TOF MS and morphological characteristics, respectively. Genetic similarity of Candida spp. isolates was evaluated using Amplified fragment length polymorphism (AFLP), and the antifungal susceptibility profile was determined by broth microdilution. RESULTS: In the study, 64.11% of patients were orally colonised by Candida spp. Of these, 80.59% were colonised within the first 24 h. Oral colonisation also occurred on subsequent days: 50%/Day 2, 26.92%/Day 4, and 11.53%/Days 6 and 8. Of the patients, 8.61% had oral candidiasis, mainly pseudomembranous. Among orally colonised patients, 2.23% developed invasive candidiasis. Besides, 89.47% of healthcare professionals evaluated were colonised. MALDI-TOF MS identified different yeast species, and C. albicans (45.34%), C. tropicalis (15.7%), and C. parapsilosis sensu stricto (9.88%) were the most prevalent. AFLP analysis indicated a high genetic correlation (≥97%) between C. parapsilosis sensu stricto isolates from patients and professionals. Three resistant C. albicans isolates were also found. CONCLUSION: This study reported a diversity of yeast and filamentous fungi species in ICU patients and highlighted early Candida spp. colonisation risks for invasive candidiasis, as well as the potential horizontal transmission in the nosocomial setting, emphasising the need for effective infection control measures.
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Candida , Personal de Salud , Unidades de Cuidados Intensivos , Humanos , Masculino , Femenino , Persona de Mediana Edad , Candida/genética , Candida/aislamiento & purificación , Candida/efectos de los fármacos , Candida/clasificación , Anciano , Adulto , Antifúngicos/farmacología , Antifúngicos/uso terapéutico , Infección Hospitalaria/microbiología , Infección Hospitalaria/epidemiología , Pruebas de Sensibilidad Microbiana , Candidiasis Bucal/microbiología , Candidiasis Bucal/epidemiología , Candidiasis Invasiva/microbiología , Candidiasis Invasiva/epidemiología , Anciano de 80 o más Años , Análisis del Polimorfismo de Longitud de Fragmentos Amplificados , Boca/microbiologíaRESUMEN
Beach volleyball (BV) is an intermittent sport characterised by short-duration and highly demanding activities with low intensity periods. Establishing if players' jump ability is influenced by sand granulometry is a useful information for sport scientists, coaches and players. This study aimed to assess the possible differences in the kinetics parameters of the vertical jump on different types of sand performed by BV players. Twelve elite female players performed six countermovement jumps (CMJs) in three different surface conditions (fine sand, reference, coarse sand) in a random counterbalanced order (216 jumps). A generalised mixed model approach detected differences for CMJ model in total duration (p: 0.016), eccentric phase duration (p: 0.007), concentric phase duration (p: 0.011), time to peak power (p: < 0.001), time to peak force (p: 0.014), maximum rate force development concentric phase (p: 0.004), maximum velocity (p: 0.028) and peak power eccentric (p: 0.018). Coarse sand decreases the time spent jumping compared to fine sand, without a penalty to jump height. Coaches and athletes should take this information into account to enhance their understanding of practice strategies and game conditions. One might anticipate a faster pace in games played on coarse sand and a slower pace on fine sand.
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Since its first report, the class A Brazilian Klebsiella carbapenemase (BKC) has been detected only among Enterobacterales isolates from Brazilian hospitals. In this study, we characterized a multidrug-resistant Pseudomonas juntendi clinical isolate and identified a 43.3-kb plasmid carrying blaBKC-1 and a class 1 integron (In1996) containing the arr-2, qnrVC1, dfrA21, and aac(6')-Ib' gene cassettes. Our results confirm the ability of Pseudomonas putida group isolates to acquire antimicrobial resistance determinants and further act as resistance reservoirs.
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Carbapenémicos , Pseudomonas putida , Carbapenémicos/farmacología , Klebsiella , Pseudomonas putida/genética , Brasil , Antibacterianos/farmacología , Pseudomonas , beta-Lactamasas/genética , Proteínas Bacterianas/genética , Pruebas de Sensibilidad MicrobianaRESUMEN
Corona mortis é a denominação da anastomose entre os vasos obturadores e a ilíaca externa, que cruzam sobre o ramo ílio-púbico. O conhecimento da anastomose pode evitar complicações trans e pós-operatórias durante os tratamentos de lesões pélvicas com fixações internas. O presente estudo avalia a prevalência, o calibre, a distância da sínfise púbica e a presença de anastomose arterial e/ou venosa...
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Humanos , Pelvis/lesiones , Pelvis/cirugía , Anastomosis Arteriovenosa/anatomía & histología , Arteria Ilíaca/anatomía & histologíaRESUMEN
A Síndrome de Prader-Willi é uma doença rara, congênita, que acomete 1 a cada 15 mil nascimentos, caracterizada por hipogonadismo, hiperfagia com obesidade mórbida, baixa estatura, retardo mental, fácies dismórfica, sendo originada de uma anormalidade no braço longo do cromossomo 15 no locus 15q 11-13 de origem paterna. Relata-se caso de Síndrome de Prader-Willi, com revisäo da literatura, apresentando características clínicas, genéticas, dietéticas, metabólicas e tratamento
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Humanos , Masculino , Niño , Síndrome de Prader-Willi/diagnóstico , Síndrome de Prader-Willi/etiología , Síndrome de Prader-Willi/terapia , Hipogonadismo , Obesidad , Obesidad MórbidaRESUMEN
A Blastomicose sul-americana é uma doença granulomatosa crônica, causada pelo Paracoccidioides brasiliensis, cuja principal manifestaçäo é pulmonar, podendo disseminar-se por vários órgäos. O acometimento ósseo pela Blastomicose é raro, podendo apresentar-se associado à doença sistêmica ou isolado. Os autores descrevem um caso de Blastomicose Össea, fazendo revisäo dos aspectos etiopatogênicos, clínicos, diagnósticos, diagnótico diferencial, tratamento medicamentoso e cirúrgico do envolvimento ósseo pela doença
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Humanos , Femenino , Anciano , Paracoccidioidomicosis/diagnóstico , Paracoccidioidomicosis/etiología , Paracoccidioidomicosis/fisiopatologíaRESUMEN
Realizou-se um estudo transversal e prospectivo em tomografias compputadorizadas, analisando calcificaçöes encefálicas de Neurocisticercose no período de 18/10/93 a 21/03/94 no Hospital Universitário Säo Vicente de Paulo - Passo Fundo, RS, no Serviço de Radiologia. Tentou-se determinar a prevalência da patologia na regiäo. Foram avaliadas 1.088 Tomografias computadorizadas do crânio-encéfalo, observando-se que 146 apesentaram calcificaçöes encefálicas compatíveis com Neurocisticercose, determinando uma prevalência de 13,41 por cento e indicando que esta regiäo deve ser incluida entre as zonas endêmicas da doença no Brasil