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The coagulative activity was studied of the arterial and venous blood thrombocyte and thrombocyte-free plasma in 16 patients with stable angina. Changes in the general index of thrombophilia permitted the identification of activation of the hemostatic potential in the venous and arterial beds. The results secured suggested the important part that platelets have in formation of the hemostatic potential in both the venous and arterial beds in stable stenocardia. Discussed in the article is the role of the lungs in stabilization of the hemostatic potential in the arterial bed.

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Coagulating activity was studied of the arterial and venous blood platelet-rich and platelet-poor plasma in 16 patients with unstable angina (UA). An unusual activation of the hemostatic potential was recordable in the venous and arterial beds, as per changes in the general index of thrombophilia, which fact, along with the presence of FDR and fibrin-monomer complexes, can be regarded as signs of disseminated intravascular coagulation which can cause thrombogenic complications in UA patients. Changes in the system of hemostasis in the above patients (as evidenced by the index of thrombophilia) might suggest the prethrombotic state. The results obtained showed that platelets had an important role in the formation of the hemostatic potential both in the venous and arterial blood in UA.

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In 20 patients with acute myocardial infarction the parameters of coagulation and fibrinolysis were evaluated. A high degree of the correlation between the routine and turbidimetric methods was found. Turbidimetric express-micromethod may be widely used for monitoring coagulation and fibrinolysis parameters in patients with acute myocardial infarction.

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Data are analysed on current rating form of training and knowledge control at the chair of propedeutics of internal diseases based on 900 tests. The efficacy of this system is confirmed.

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A technique was designed for the treatment of duodenal ulcer patients by electromagnetic radiation of the millimeter range (ERMR); 30 patients were treated by this method, while 50 patients received traditional therapy; other patients were treated by lasers, cithemidin. Endoscopic ERMR treatment in combination with drugs was more effective than other methods.

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The authors analyze the efficacy of their method of prolonged analgesia in acute myocardial infarction. A comparison of the clinical efficacy of epidural analgesia with obsidan and local anesthetics hemodynamic effects of epidural and intravenous administration of obsidan indicates that use of the new method of analgesia ensures adequate anesthesia, provides an improvement of the clinical course of the disease and has no adverse effects on the circulation.

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Capoten was used in the treatment of 28 patients with macrofocal myocardial infarction associated with marked acute cardiac insufficiency. 1.5 hours following intake of 6.25 mg of Capoten the arterial pressure reduced, the general peripheral vascular resistance, left ventricle filling pressure also reduced and this was accompanied by a reduction of rate of cardiac contractions, increase of cardiac ejection. No side effects related to Capoten treatment were observed.

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Venous and arterial coagulation and fibrinolytic activity, particularly total hemostatic potential, its plasma and platelet constituents, and functional platelet properties were examined within the first hours of acute myocardial infarction in 106 patients. Those were divided into groups with uncomplicated, recurrent and spread myocardial infarction, and with cardiogenic shock. Early signs of disseminated intravascular coagulation were registered within the first hours of the disease in the venous (more prominently) and arterial (less prominently) channels. True cardiogenic shock is associated with more apparent symptoms of the disseminated intravascular coagulation syndrome in venous and arterial blood.

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Methods of clinico-instrumental investigation and biochemical monitoring (CPK and its membranous fraction) were employed for examination of 432 patients with acute myocardial infarction (AMI). Among them there were patients with an uncomplicated course of disease (19.4%), recurrences (13.7%) and AMI spreading (9%). Lung edema, a cardiogenic shock, ventricular fibrillation and complicated cardiac rhythm disorders were not detected on the 1st day of disease. Clinico-anamnestic data provided no opportunity for defining factors promoting AMI recurrences whereas AMI spreading frequently developed in patients with repeated AMI, suffering from essential hypertension, obesity and heart failure. Higher diastolic pressure in the pulmonary artery, an increase in the cardiac volume, a decrease in the ejection fraction and left ventricular stroke work--changes which were most pronounced in AMI spreading, were noted in patients with AMI lingering forms. Signs of disseminated intravascular blood coagulation were noted in the venous and arterial blood of patients with lingering AMI forms. A high blood enzyme level was shown to be accompanied by a low level of antibodies to LDH and CPK.

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To differentiate between various forms of cardiogenic shock (CS) and to elaborate the criteria of its prognosis, the authors examined 284 patients with acute myocardial infarction (MI) and 30 patients of the control group for the peculiarities of the clinical course of the disease in relation to changes in the hemodynamic parameters and oxygen supply to the tissues. CS was shown to develop more frequently in patients over 64 years of age, with a history of MI and with signs of chronic circulation insufficiency of IIA stage. Late CS more commonly took the true form and was associated with a MI relapse. Reflex CS was characterized by the hyperkinetic variant of the hemodynamics while an arrhythmic one by the congestive variant. Patients with the authentic form of CS were divided into 3 subgroups with different hemodynamic reactions to sympathomimetic amines. In the first day of the disease the coefficient of the tissue extraction of oxygen serves as a significant prognostic criterion which should be determined along with the dynamic measurement of the pump and contractile functions of the heart.

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