RESUMEN

Streptozotocin-induced diabetes resulted in a decrease in the cathepsin D activity (free and total) in rat liver, kidney, brain and heart with a concomitant increase in tissue protein content and amino acids pool size. Treatment with insulin brought about the restoration of the cathepsin D activity to normal or greater than normal levels; tissue protein content and amino acids pool size also returned to normal values.

Asunto(s)

Catepsina D/metabolismo , Diabetes Mellitus Experimental/enzimología , Insulina/farmacología , Lisosomas/enzimología , Aminoácidos/metabolismo , Animales , Encéfalo/enzimología , Diabetes Mellitus Experimental/tratamiento farmacológico , Insulina/uso terapéutico , Riñón/enzimología , Hígado/enzimología , Masculino , Miocardio/enzimología , Ratas , Ratas Endogámicas