1.
Dokl Akad Nauk
; 326(4): 742-5, 1992.
Artículo
en Ruso
| MEDLINE
| ID: mdl-1362511
Asunto(s)
Hipocampo/efectos de los fármacos , Neuronas/efectos de los fármacos , Receptores de N-Metil-D-Aspartato/antagonistas & inhibidores , 2-Amino-5-fosfonovalerato/farmacología , Potenciales de Acción , Aminoácidos/farmacología , Animales , Anticonvulsivantes/farmacología , Conducta Animal/efectos de los fármacos , Hipocampo/citología , Ratones , N-Metilaspartato/farmacología , Neuronas/fisiología , Ratas , Especificidad de la Especie
2.
Biull Eksp Biol Med
; 108(9): 299-302, 1989 Sep.
Artículo
en Ruso
| MEDLINE
| ID: mdl-2558743
RESUMEN
N-methyl-DL-aspartate induced in mice and rats hyperactivity and convulsions. In the mice convulsions effectively suppressed by selected antagonists of NMDA receptors AP 5 and AP 7, and also diazepam and ketamine. But hyperactivity very little attenuated by these substances in high doses. In the rats all these substances on the contrary suppressed hyperactivity and convulsions in the same degree. In the rats hynurenic acid prevented hyperactivity and convulsions. Observations point out to the fact that in mice there are two pharmacological and functional types of NMDA receptors whereas in rats there is only one type which is different from NMDA mice receptors.