RESUMEN
The preliminary application of the preparation Oxadiarrhot has no effect on the progress and the result of bacterial and mixed (bacterial-viral) infections. In animals treated with the preparation antigen-reactive and antibody-productive cells show insignificant decrease in number. There is no essential influence of the preparation on the mononuclear phagocytes system--the alveolar macrophages and polymorphonuclears do not change their functions.
Asunto(s)
Antivirales/farmacología , Sistema Inmunológico/efectos de los fármacos , Oxazinas/farmacología , Animales , Antivirales/uso terapéutico , Evaluación Preclínica de Medicamentos , Cobayas , Sistema Inmunológico/inmunología , Inmunidad Celular/efectos de los fármacos , Virus de la Influenza A , Infecciones por Klebsiella/tratamiento farmacológico , Infecciones por Klebsiella/inmunología , Klebsiella pneumoniae , Ratones , Infecciones por Orthomyxoviridae/tratamiento farmacológico , Infecciones por Orthomyxoviridae/inmunología , Oxazinas/uso terapéutico , Fagocitosis/efectos de los fármacos , Ratas , Ratas WistarRESUMEN
The immunomodulating effect on mice of three products glucomacropeptides obtained from whey with different carbohydrate and peptide components has been studied. After the preliminary application of the preparations at several doses the protective effect in infections with Salmonella typhimurium and Klebsiella pneumoniae increases to different extent. At lower doses fraction 3 increases in vitro the mitogen-induced proliferation of the thymus cells. The phagocytosis of the polymorphonuclear cells on the 24th hour after application of the three preparations is activated. The influence of the structurally different fractions on the immunoprotective effect is discussed.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Inmunidad Innata/efectos de los fármacos , Proteínas de la Leche/uso terapéutico , Adyuvantes Inmunológicos/farmacología , Animales , División Celular/efectos de los fármacos , Células Cultivadas/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Inmunidad Innata/inmunología , Infecciones por Klebsiella/inmunología , Infecciones por Klebsiella/prevención & control , Klebsiella pneumoniae , Ratones , Proteínas de la Leche/farmacología , Fagocitosis/efectos de los fármacos , Fagocitosis/inmunología , Salmonelosis Animal/inmunología , Salmonelosis Animal/prevención & control , Salmonella typhimurium , Linfocitos T/citología , Linfocitos T/efectos de los fármacos , Factores de Tiempo , Proteína de Suero de LecheRESUMEN
The stimulating properties of three fractions of a glucomacropeptide consisting of different carbohydrate and peptide components were studied. The phagocytic activity of polymorphonuclears was increased on the 24th hour and of macrophages on the 3rd day after application of the preparations to mice. In vitro fraction 3 stimulates the lysozyme activity and the synthesis of proteins and Clq of the macrophages complement. These properties of the cells are collaborated by the established ultrastructural changes. The different composition of the fractions determines their immunostimulating effect.