RESUMEN

The antiarrhythmic activity and acute toxicity of polymeric formulations of quinidine, trimecaine, ethacizine, propranolol, verapamil which had been immobilized on a cellulose carrier (monocarboxylcellulose) and low molecular analogues were studied in various experimental animals (rats, mice, dogs). The polymeric formulations of trimecaine and verapamil were found to have a higher antiarrhythmic activity in different arrhythmia models than trimecaine and verapamil. The toxicity of all new compounds was no more than the values of conventional antiarrhythmic drugs.

Asunto(s)

Antiarrítmicos/uso terapéutico , Fenotiazinas/uso terapéutico , Propranolol/análogos & derivados , Quinidina/análogos & derivados , Trimecaína/análogos & derivados , Verapamilo/análogos & derivados , Animales , Antiarrítmicos/toxicidad , Arritmias Cardíacas/inducido químicamente , Arritmias Cardíacas/tratamiento farmacológico , Arritmias Cardíacas/mortalidad , Evaluación Preclínica de Medicamentos , Femenino , Masculino , Ratones , Fenotiazinas/toxicidad , Polímeros , Propranolol/uso terapéutico , Propranolol/toxicidad , Quinidina/uso terapéutico , Quinidina/toxicidad , Ratas , Trimecaína/uso terapéutico , Trimecaína/toxicidad , Verapamilo/uso terapéutico , Verapamilo/toxicidad