RESUMEN
Eviscerated hepatectomised rats maintained on a protein-free diet are not able to reduce their oxidation of injected valine and mixed amino acids compared to rats given a high protein diet. This suggests that the extra-hepatic tissues in the protein-depleted rats are not able to adapt to protein depletion and this high oxidation may be implicated in the observed low levels of branched-chain amino acids found in the blood of protein-depleted rats(AU)
Asunto(s)
21003 , Ratas , Aminoácidos/metabolismo , Deficiencia de Proteína , Proteínas en la Dieta , HepatectomíaAsunto(s)
Enfermedades Carenciales/metabolismo , Fiebre/metabolismo , Absorción Intestinal , Hierro/metabolismo , Anemia Hipocrómica/etiología , Ácido Ascórbico , Vacunas Bacterianas , Peso Corporal , Examen de la Médula Ósea , Enfermedades Carenciales/etiología , Femenino , Fiebre/complicaciones , Humanos , Lactante , Hierro/sangre , Isótopos de Hierro , Jamaica , Kwashiorkor/metabolismo , Masculino , Vacuna contra la Tos Ferina , RadiometríaRESUMEN
An incidental finding led to a more detailed study of the effect of fever on iron absorption. The absorption of 59Fe-labelled ferrous ascorbate was measured by whole-body counting in nineteen malnourished Jamaican infants and young children. Tests were done at various stages of refeeding, and it was found that the presence of a febrile illness or the febrile response to diptheria-pertussis-tetanus immunisation profoundly depressed iron absorption. This effect was not related to the nutritional state of the patient. Recurrent minor febrile illnesses are common in this group of children and may contribute to the production of iron deficiency.(Summary)