RESUMEN
Plasma testosterone (T), 5 alpha-dihydrotestosterone (DHT), T/DHT ratio, estrone (E1), estradiol (E2), E2/T ratio and 17-hydroxyprogesterone (17-OH-P) were measured in 70 patients with prostatic carcinoma (PCA) (T34, N01, M01), after endocrine therapy including: steroidal estrogens (polyestradiol phosphate = Estradurin monthly in injections of 80 mg; estradiol - 17 beta: 5 mg/d), nonsteroidal synthetic estrogens (DES: 5 mg/d; chlorotrianisene = TACE: 24 mg/d; DES-diphosphate = Honvan: 360 mg/d), orchidectomy and their combinations. All these forms of treatment lowered T, DHT, T/DHT ratio and 17-OH-P, the maximal suppression being observed after castration. No further decrease of the mentioned parameters was achieved by estrogen treatment of castrated patients, as compared with castration alone. In the noncastrated patients, steroidal estrogens were less effective than nonsteroidal ones, in terms of lowering T, DHT and T/DHT ratio. Significant decreases in estrone (p less than 0.05) and estradiol (p less than 0.01) levels were observed after nonsteroidal estrogen treatment and castration respectively, and extremely high values of circulating estrogens were found after steroidal estrogen administration.
Asunto(s)
Congéneres del Estradiol/uso terapéutico , Neoplasias de la Próstata/tratamiento farmacológico , Esteroides/sangre , 17-alfa-Hidroxiprogesterona , Anciano , Castración , Dihidrotestosterona/sangre , Estradiol/sangre , Estrona/sangre , Humanos , Hidroxiprogesteronas/sangre , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/sangre , Testosterona/sangre , Factores de TiempoRESUMEN
A total of 12 patients were prophylactically treated with Thio-Tepa, that had presented papillary bladder tumours operated in stages T0, T1 and T2. The treatment consisted in intra-vesical instillations with 50 mg of substance solved in 50 ml of distilled water. The solution was maintained for one hour inside the urinary bladder. The instillations were repeated at 5--7 days intervals for 4 times. The following series of instillations was carried out at 3--4 months intervals by comparing the results with those obtained in a control lot it was noted that 41 percent of the patient did not recidivate over a period of between 13 and 34 months, while recidives, occurred in all the patients in the control lot. On the other hand intra-vesical instillations with Thio-Tepa have retarded in some of the cases the occurrence of tumoral recidives (22 percent of the patients recidivated in the first 6 months, in contrast with the controls in whom recidives occurred in 72 percent in the same time interval). No secondary effects were noted as a result of the endo-vesical instillations with the preparation.
Asunto(s)
Tiotepa/uso terapéutico , Neoplasias de la Vejiga Urinaria/cirugía , Humanos , Cuidados Posoperatorios , Complicaciones Posoperatorias , Recurrencia , Tiotepa/administración & dosificación , Neoplasias de la Vejiga Urinaria/tratamiento farmacológicoRESUMEN
The author discusses, on the basis of 457 cases of recidivating renal lithiasis (representing 16% of the total number lithiasis cases hospitalized over a period of 28 years in the "Panduri" Hospital of Bucharest), the problem of false recidives, the causes that lead to recidive, the chemical composition of the stones, evolution aspects and therapeutical indications.
Asunto(s)
Cálculos Renales/cirugía , Humanos , Cálculos Renales/etiología , Complicaciones Posoperatorias , RecurrenciaRESUMEN
The results are presented, of trans-vesical prosthatic adenomectomy without urethral probe in 40 patients. The drainage of the bladder was achieved by vesical counter-incision, according to the technique suggested by Rose and Novak. A decrease by approximately 70% of the post-operative urinary infections, was obtained.