RESUMEN

The authors made a complex evaluation of the physical development of 7-16-year-old rural schoolchildren from a large administrative territorial entity and developed age-gender-related standards, by using the percentile technique. There were significant morphofunctional differences between the urban and rural schoolchildren at the present stage of a secular trend, which determines the necessity of developing the physical development standards for rural children and adolescents in order to correctly interpret the data on their health status.

Asunto(s)

RESUMEN

The subjects of the study were 14 patients with bronchial asthma (BA) and 11 patients with chronic obstructive pulmonary diseases (COPD). A special diagnostic approach, including spirography with a broncholytic test after inhalation loading (IL), was developed and applied to these patients in order to optimize diagnostics and differentiation diagnostics of BA. IL included the use of hypertonic sodium chloride solution inhalation. The control group consisted of 10 patients with non-obstructive chronic bronchitis and 22 healthy individuals. The results show that bronchial reaction to IL is different in patients with BA and COPD, and demonstrate that this diagnostic approach is appropriate when evaluating the peculiarities of bronchial patency. This allows more accurate diagnostics and differential diagnostics of BA and COPD, optimization of patient grouping for scientific studies, including genetic ones, and is interesting from the perspective of therapy prediction in patients with these diseases.

Asunto(s)

Asunto(s)

RESUMEN

Enzyme activities in the circulating lymphocytes permit to judge the character of the regenerative process in the lung, and the severity of the patient's condition; it helps in estimating the prognosis and in evaluating the efficacy of the applied therapy. Potassium orotate and Riboxin intensify the regenerative process in the lung undergoing a compensatory-hypertrophic rearrangement, and enhance the functional activity of circulating lymphocytes as participants of the regenerative process and stimulate the oxidation-reduction processes in lymphocytes.

Asunto(s)

RESUMEN

In experiments on albino rats using cytochemical, autoradiographic, histological and biometrical methods of investigation the authors have shown the participation of the lymphoid system in the development of the compensatory hypertrophic rearrangement in the lung following left-sided pulmonectomy under conditions of regeneration stimulation by exposure to pyrimidine (potassium orotate) and purine (riboxin) derivatives. The dynamics of the regenerative process in the lung, its intensity and stage-by-stage character are clearly reflected in the enzymatic activity of circulating lymphocytes and in synthetic processes in the thymus and spleen.

Asunto(s)

Asunto(s)

Asunto(s)

RESUMEN

The effect of orotic acid on pulmonary regeneration has been studied in mature rats after left-sided pneumonectomy. A complex morphometric analysis of the pulmonary parenchyma during the process of compensatory-hypertrophic rearrangement has been carried out; mitotic activity of cells in the interalveolar septae, peculiarities of DNA synthesis and those of enzymatic status in lymphocytes of the peripheral blood have been determined. As the investigations have demonstrated, the administration of orotic acid during the postoperative period contributes to a more complete regeneration of the lung volume, alveolar surface, results in formation of new alveoli, prevents the development of morphologic long-term decompensation following pneumonectomy. Activation of the alveolar cells proliferation and increased DNA synthesis are the main stimulating effects of orotic acid. Certain correlative connections are revealed between the course of pulmonary regenerative processes and the enzymic status of circulating lymphocytes.

Asunto(s)

RESUMEN

The effect of orotic acid on the development of compensatory pulmonary hypertrophy has been studied in the clinic and in the experiments (71 patients, and 349 rats) carried out with the use of morphologic, biochemical cytochemical, immunologic and clinical methods, and also through autoradiography. The results of the study prove the effect of the drug upon the pulmonary regeneration. Experimental findings have shown that behind the stimulating effect of the drug there is the activation of the synthesis of nucleinic acids, the rise of the mitotic activity of the interalveolar membranes cells of the lung remnants. An essential increase of the lymphocytic dehydrogenase activity of the peripheral blood occurred in response to the effect of the drug.

Asunto(s)