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Purpose. The aim of this study was to estimate the effectiveness of surgery in liver metastasis from colorectal cancer. Methods. We conducted a prospective and observational study of patients with colorectal liver metastasis operated on at the San Cecilio University Hospital of Granada from March 2003 until June 2013. The primary variables of the result were survival and morbidity before 30 days of the post-operative period. We also measured preoperative and surgical variables. Results. A total of 147 patients with liver metastasis of colorectal origin underwent surgical removal during the period of study, 38 of whom had repeat surgery. 34 had a second resection, 3 had a third one and one only patient had a fourth one, for a total of 185 registered operations. The global 5-year survival rate was 38 and 17 % after 10 years. There were 115 patients who had neither radiofrequency nor exploratory laparotomy, 38 % of them survived over 60 months. The average disease-free time was 23.6 months ± 47.3, with significant differences observed between types of procedures. Patients that were operated on just once (n = 25) had a five-year actuarial survival rate of 35 %, a morbidity rate of 24 % and a mortality rate of 0.6 % (1 patient only). The average hospital stay was 13.8 days and the disease-free time was 15.8 months. Conclusion. The results obtained in our surgical unit in terms of morbidity, mortality and five-year actuarial survival rates are comparable to those of other units at large institutions, which are currently considered the standards of quality (AU)

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PURPOSE: The aim of this study was to estimate the effectiveness of surgery in liver metastasis from colorectal cancer. METHODS: We conducted a prospective and observational study of patients with colorectal liver metastasis operated on at the San Cecilio University Hospital of Granada from March 2003 until June 2013. The primary variables of the result were survival and morbidity before 30 days of the post-operative period. We also measured preoperative and surgical variables. RESULTS: A total of 147 patients with liver metastasis of colorectal origin underwent surgical removal during the period of study, 38 of whom had repeat surgery. 34 had a second resection, 3 had a third one and one only patient had a fourth one, for a total of 185 registered operations. The global 5-year survival rate was 38 and 17 % after 10 years. There were 115 patients who had neither radiofrequency nor exploratory laparotomy, 38 % of them survived over 60 months. The average disease-free time was 23.6 months ± 47.3, with significant differences observed between types of procedures. Patients that were operated on just once (n = 25) had a five-year actuarial survival rate of 35 %, a morbidity rate of 24 % and a mortality rate of 0.6 % (1 patient only). The average hospital stay was 13.8 days and the disease-free time was 15.8 months. CONCLUSION: The results obtained in our surgical unit in terms of morbidity, mortality and five-year actuarial survival rates are comparable to those of other units at large institutions, which are currently considered the standards of quality.

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Introducción. Los tumores de la ampolla de Vater constituyen el 10 por ciento de los cánceres periampulares. Son de crecimiento más lento y tienen mejor pronóstico que los del páncreas, por lo que algunos autores recomiendan ampulectomías en determinados casos. En este trabajo analizamos nuestros resultados en el tratamiento de esta enfermedad, para el que se han utilizado diversas técnicas quirúrgicas. Pacientes y método. Estudio retrospectivo de datos perioperatorios, morbimortalidad y supervivencia en un grupo de 20 pacientes intervenidos por adenocarcinoma ampular. Resultados. Fueron intervenidos 14 varones y 6 mujeres, con una edad media de 65 años. El síntoma principal fue la ictericia (75 por ciento); la bilirrubina media fue de 7,67 mg por ciento; la prueba diagnóstica más resolutiva fue la colangiopancreatografía retrógrada endoscópica, con un 78,6 por ciento de verdaderos positivos. Las intervenciones realizadas fueron: 12 duodenopan createctomías cefálicas, 2 duodenopancreatectomías totales, 3 ampulectomías y 3 derivaciones. La mortalidad fue del 5 por ciento. En cuanto a las recidivas se produjeron 1/3 tras ampulectomía a los 10 meses frente a 1/11 tras duodenopancreatectomía cefálica a los 4 años. La supervivencia global fue de 37,11 meses. Conclusiones. El síntoma más frecuente en estos tumores es la ictericia y la prueba diagnóstica más rentable la colangiopancreatografía retrógrada endoscópica. La técnica de elección sigue siendo la duodenopancreatectomía cefálica (AU)

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We present the results of an in vitro study of biliary lithiasis (n = 106) with computerized tomography (CT). We analyzed the correlation between composition of gallstones (crystallographic analysis of thin sections and atomic absorption spectrophotometric analysis of total calcium content) with CT patterns (densitometry) and their corresponding attenuations. Six main CT patterns were distinguished: hypodense (homogeneous and heterogeneous), dense, homogeneous hyperdense, ringed hyperdense and irregular hyperdense. Statistically significant differences (p < 0.05) were found between attenuations for cholesterol (mixed and pure) and pigmentary stones. We found a good inverse correlation between attenuations and cholesterol content; the contents of pigment, inorganic calcic salts and total calcium content also showed significant direct correlations (p < or = 0.01). Of the samples classified as pure cholesterol type stones, 86.4% showed hypodense patterns, and the remaining 13.6% showed irregular hyperdense patterns. Of the pigmentary stones, 80% showed homogeneous hyperdense images. All stones that contained more than 3% calcium produced hyperdense patterns, whereas 72.4% of the stones that contained less calcium produced hypodense images. Tomodensitometric measurements provided more information than simple radiography, and made it possible to distinguish a greater variety of gallstone types based on structural complexity.

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One hundred forty-four patients, peptic (129 males and 15 females) treated for peptic ulcer perforation between 1972 and 1988 were reviewed. All were treated surgically, and in 28 the ulcer was also treated. The mean perforation time before treatment was 14 +/- 12.3 hours. The immediate postoperative results and long-term evolution were evaluated on the basis of the medical history, follow-up check-ups and home questionnaires. The were post-operative complications in 33 (23%) of the 137 patients who survived surgery; there was no difference in morbidity between the group in which only Closure and Epiploplasty (group C + E) were performed and group CD, where some type of definitive surgery was added, although the seven deaths belonged to the former. Of the 104 patients who were evaluated on a long-term basis (follow-up period of 55 +/- 44 months), poor results were obtained in 58 of the 82 belonging to group C + E and in four of the 28 in group CD, with a total of 13 re-operations (12 and one, respectively). Only a previous ulcer history dating from over three months had any effect on the appearance of recurrences in group C + E. We recommend performing a VGP within the first six hours as the preferred technique for pyloric or juxtapyloric perforations in patients with a previous ulcer history exceeding three months, since the rate of cure is satisfactory and there are few if any complications.

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We present 114 cases of proximal gastric vagotomy (VGP), performed between December 1975 an December 1986 (11 years) and followed-up until December 1987 (12 years). An hundred patients underwent elective surgery and 14 emergency. We obtained good results in 97 patients (85.83%) moderate in 10 (8.85%) and poor in six (5.30%) with one mortality (0.87%) due to causes not related to the operation. We emphasize the surgical indication and technique, which, if correctly established, make proximal gastric vagotomy the ideal surgical intervention for gastroduodenal ulcer.

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