RESUMEN
We carried out spectral analysis of variability of 6 parameters of hemodynamics (cardiac rhythm, stroke volume, ejection fraction, amplitude of pulsation of the aorta, amplitude of pulsation of microvessels of foot, systolic arterial pressure). We created a classification of oscillatory activity of these parameters on the basis of values of total power of spectrum of variability of parameters of hemodynamics in 4 frequency ranges. In arterial hypertension we revealed changes of total oscillatory activity of heart rhythm, ejection fraction, amplitude of pulsation of microvessels of the foot finger.
Asunto(s)
Hemodinámica , Hipertensión/fisiopatología , Femenino , Humanos , MasculinoRESUMEN
The study was designed for spectral analysis of cardiac rhythm variability (CRV) in practically healthy subjects and patients with AH. Classification of oscillatory cardiac rhythm activity is proposed based on CRV characteristics in four frequency ranges, viz. ultralow frequency (ULF), very low frequency (VLF), low frequency (LF), and high frequency (HF). Three types of CRV are distinguished (low, medium, and high-amplitude). Differential hypotensive therapy is recommended depending on the initial CRV level. Patients with AH and markedly narrowed CRV spectrum should be treated with beta-adrenoblockers, those with moderate and elevated CRV with ACE inhibitors and calcium antagonists respectively. Modern computer technologies for the analysis of slow-wave events in blood circulation may be used to evaluate regulatory process and thereby to facilitate the choice of adequate therapy.
Asunto(s)
Antagonistas Adrenérgicos beta/uso terapéutico , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Bloqueadores de los Canales de Calcio/uso terapéutico , Ritmo Circadiano/fisiología , Frecuencia Cardíaca/fisiología , Hipertensión/tratamiento farmacológico , Adulto , Presión Sanguínea/efectos de los fármacos , Presión Sanguínea/fisiología , Ritmo Circadiano/efectos de los fármacos , Electrocardiografía Ambulatoria , Femenino , Estudios de Seguimiento , Humanos , Hipertensión/fisiopatología , Masculino , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
Analysis of spectral parameters of vascular blood flow variability revealed some sex-related peculiarities. The amplitude of aortic pulsation and total variability power of this parameter and its four components (ultralow frequency, very low frequency, low frequency, and high frequency range) were higher in women. The amplitude of microvascular pulsation and total variability power of this parameter and components were higher in men. In male patients, the relative variability power for the amplitude of microvascular pulsation was higher in the high frequency and low frequency ranges, but lower in the very low frequency and ultralow frequency ranges.
Asunto(s)
Circulación Sanguínea/fisiología , Caracteres Sexuales , Adulto , Velocidad del Flujo Sanguíneo , Femenino , Frecuencia Cardíaca/fisiología , Hemodinámica , Humanos , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
The study involved 135 apparently healthy students 17 - 21 years old. Bioimpedance tetrapolar rheopolygraphy based on Kentavr computer system was employed in studied subjects in supine position at rest. Examined subjects, regarding their percental volume of cardiac index (CI) - 25 and 75, were included into three groups with hypokinetic (CI was lower than 2.0 L/min/m2), eukinetic (CI ranged from 2.0 to 3.0 L/min/m2) and hyperkinetic (CI was more than 3.0 L/min/ m2) hemodynamic pattern. The evaluation of blood flow indices showed that heart rate, stroke volume, minute blood volume, cardiac index, rheogram amplitude were lower in hypokinetic type, but photoplethysmogram was higher when compared with both eukinetic and hyperkinetic types. Power spectral analysis of heart rate variability demonstrated that components of heart rate power frequencies, absolute values of the heart rate power oscillations at four frequencies ranges (UVLF, VLF, LF, HF) as well as relative values of heart rate power spectrum in LF and VLF were lower, but relative values of high-frequency components were higher compared to other two hemodynamic patterns. These data demonstrate that hypokinetic type of circulation was sparer in healthy subjects of juvenile age.
Asunto(s)
Frecuencia Cardíaca/fisiología , Adolescente , Adulto , Circulación Cerebrovascular/fisiología , Femenino , Hemodinámica/fisiología , Humanos , MasculinoRESUMEN
A programme on supplementary health education of medical staff from city polyclinics in the prevention and treatment of arterial hypertension was launched in one of the Moscow districts for 3 years. Another district was used as a comparison subject. Representative samples of residents aged 35-64 years from the two districts were screened before and after implementation of the programme. The WHO International MONICA programme was used to evaluate the efficiency of the programme proposed by the authors. The intervention district showed an improvement of hypertensives' awareness of the disease and a double increase in the number of patients with a high compliance. In the comparison district, these parameters remained unchanged. According to the criteria developed in the MONICA programme, there was a downward tendency in the incidence of myocardial infarction and stroke and these diseases-related deaths in the intervention district, whereas this was not observed in the district under comparison.
Asunto(s)
Hipertensión/prevención & control , Cuerpo Médico/educación , Adulto , Factores de Edad , Trastornos Cerebrovasculares/mortalidad , Femenino , Promoción de la Salud/métodos , Humanos , Hipertensión/epidemiología , Hipertensión/mortalidad , Hipertensión/terapia , Masculino , Persona de Mediana Edad , Moscú/epidemiología , Infarto del Miocardio/mortalidad , Factores de Riesgo , Factores Sexuales , Enseñanza/métodos , Población Urbana/estadística & datos numéricos , Organización Mundial de la SaludRESUMEN
In 5 patients with myocardial infarction the ways of the inosine transformation and its clearance rate following injection of this drug in an amount of 200 to 400 mg were studied. After inosine introduction into the organism it is shown to immediately break down to hypoxanthine which makes determination of its half-time body retention period practically impossible. The half-time body retention period for hypoxanthine was about 3 min. The beneficial influence of inosine on the myocardium is apparently due to stimulation of some glycolysis reactions and pentosophosphate shunt at the expense of riboso-1-phosphate.