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RESUMEN

OBJECTIVE: Perform genotyping of SNPs in the promoter region of the SMO gene in BCC samples from patients from northeastern Brazil, and to determine if there is an association of these SNPs of the gene in question with the susceptibility to the development of the BCC. METHODS: 100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific - PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value.

Asunto(s)

Carcinoma Basocelular/genética , Islas de CpG/genética , Metilación de ADN/genética , Polimorfismo de Nucleótido Simple/genética , Regiones Promotoras Genéticas/genética , Neoplasias Cutáneas/genética , Receptor Smoothened/genética , Alelos , Biomarcadores de Tumor/genética , Brasil , Predisposición Genética a la Enfermedad/genética , Humanos , Estudios Retrospectivos

RESUMEN

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