RESUMEN
The care of pregnant women and neonates in peripheral hospitals in many developing countries is in a critical state. Through a retrospective analysis we assessed the effects of the introduction of standardised protocols in obstetric and neonatal care (implementation from 1998 onwards) on perinatal and neonatal outcomes of all deliveries over seven years (1996-2002) at a first-referral hospital in rural Tanzania. In all, there were 18 026 deliveries (18 316 live births and 606 stillbirths). Perinatal mortality rates (PMR) varied from 42.8-54.5/1000 live births during the years. Early neonatal mortality rates (eNMR) fell from 21.9/1000 live births in 1996 to 14.8/1000 live births in 2002 (all p > 0.05). Fresh stillbirth rates decreased over time (p = 0.041), however macerated stillbirth rates increased during the second half of the period (p = 0.067). Sixty-two to seventy-two percent of eNMR occurred on the first day of life (p < 0.001). Maternal mortality ratio declined from 729/100 000 live births in 1996 to 119/100 000 live births in 2002 (p = 0.002). Our clinical project was associated with a reduction of PMR and eNMR (and maternal mortality ratios), but with considerable fluctuations during the years. Improving obstetric and neonatal care in the hospital setting in developing countries is essential, but needs long-term commitment and support.
Asunto(s)
Absceso Abdominal/patología , Enfermedades del Colon/parasitología , Entamebiasis/patología , Perforación Intestinal/parasitología , Enfermedades del Bazo/parasitología , Absceso Abdominal/diagnóstico , Absceso Abdominal/parasitología , Niño , Enfermedades del Colon/diagnóstico , Enfermedades del Colon/patología , Entamoeba histolytica/aislamiento & purificación , Entamebiasis/diagnóstico , Entamebiasis/parasitología , Resultado Fatal , Humanos , Recién Nacido , Enfermedades del Recién Nacido/diagnóstico , Enfermedades del Recién Nacido/parasitología , Perforación Intestinal/diagnóstico , Masculino , Enfermedades del Bazo/diagnóstico , Enfermedades del Bazo/patologíaRESUMEN
BACKGROUND: Clinicians at Haydom Lutheran Hospital, a rural hospital in northern Tanzania noted an unusually high case-fatality rate of pediatric meningitis and suspected an outbreak of an unknown agent or an organism resistant to the empirical therapy. METHODS: We established a provisional microbiology laboratory to investigate the suspected outbreak. Blood and spinal fluid specimens were taken from children below the age of seven years with suspected meningitis. The blood and spinal fluid specimens were inoculated in commercial blood culture bottles and locally prepared Thayer-Martin medium in slanted tubes, respectively. The bacterial isolates were sent to Norway for further investigation, including susceptibility testing and pulsed-field gel-electrophoresis (PFGE). RESULTS: Among 24 children with suspected meningitis and/or septicemia, five neonates had meningitis caused by Salmonella enterica serotype Enteritidis, all of whom died. Two children had S. Enteritidis septicemia without meningitis and both survived. Genotyping with PFGE suggested a clonal outbreak. The salmonella strain was resistant to ampicillin and sensitive to gentamicin, the two drugs commonly used to treat neonatal meningitis at the hospital. CONCLUSION: The investigation reminds us that nontyphoidal salmonellae can cause meningitis associated with very high case-fatality rates. Resistance to multiple antimicrobial agents increases the risk of treatment failure and may have contributed to the fatal outcome in all of the five patients with salmonella meningitis. The investigation indicated that the outbreak was nosocomial and the outbreak subsided after hygienic measures were instituted. Establishing a provisional microbiological laboratory is a valuable and affordable tool to investigate and control outbreaks even in remote rural areas.