RESUMEN
Correction for 'Blood brain barrier permeable gold nanocluster for targeted brain imaging and therapy: an in vitro and in vivo study' by L. V. Nair et al., J. Mater. Chem. B, 2017, 5, 8314-8321, https://doi.org/10.1039/C7TB02247F.
RESUMEN
Blood brain barrier (BBB) is a dynamic interface, comprising polarized endothelial cells, that separates the brain from the circulatory system. The highly protective nature of this tight junction impairs diagnosis and treatment of brain disorders. In this study, we designed a sub atomic size, near infrared emitting, dual function glutathione gold cluster with high fluorescence yield to facilitate permeability of BBB, for imaging applications and drug delivery. The gold cluster was then modified with Levodopa (l-dopa), to utilize the large amino acid transporter 1 (LAT1) pathways to enhance brain entry. Uptake and permeability of the nanoprobes were demonstrated using an established model of BBB, comprising brain endothelial cells (bEnd.3). The uptake and the clearance of l-dopa modified cluster was faster than the glutathione cluster. l-Dopa modified cluster supports the slow and sustained delivery of a model drug, pilocarpine, to the brain. Results of in vivo imaging and drug release in normal mice hold promise for considering the probe for early diagnosis of brain diseases, when the barrier is not disrupted, and for subsequent drug treatment.
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Development of sezary syndrome from photodermatitis induced by atenolol in a 74-year old lady is described.
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Twenty patients with extensive psoriasis of more than three years duration not responding to conventional medical treatment were studied to assess the effect of dialysis. Ten patients were subjected to haemodialysis and ten to peritoneal dialysis. Patients were periodically assessed regarding responses by standard critera. At the end of six months 4/8 (50%) in haemodialysis group and 6/10(60%) in peritoned dialysis group showed improvement. One patient in haemodialysis group developed exfoliative dermatitis eleven days after onset of dialysis. In this study though a beneficial effect in psoriasis was noted following dialysis, the effect was temporary.
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Ten patients with chronic stable psoriasis of more than three years duration were treated with injection heparin 2500 IU subcutaneously twice a day for 7 days. Six patients showed aggravation. Three showed no response and one patient improved and went into remission after 6 months.
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A case of urticaria pigmentosa mistaken for xanthoma disseminatum is presented.