RESUMEN
Due to the cost-effectivity and biodegradability advantages of pectin, this type of polysaccharide attracted the attention of many researchers for catalyst construction. Accordingly, pectin was used as a green support in this study to construct an efficient heterogeneous catalytic system based on the conjugation of metal phthalocyanines. To end this, pectin was first oxidized with periodate oxidant agent to effectively immobilize a tetra-amino copper phthalocyanine (Cu-PcTA) through a green, simple, and an efficient one-pot Ugi four-component reaction (Ugi-4CR). Then, the catalytic activity of the copper phthalocyanine-conjugated pectin was investigated in the CO2 fixation reaction to cyclic carbonates. Optimum catalytic conditions were as follows: 30 mg of prepared catalyst, 3 bar CO2 pressure, 90 °C, 2 h, and TBAB as a co-catalyst. Pectin can successfully improve the catalytical properties of the Cu-PcTA over the CO2 fixation reaction.
RESUMEN
Designing an antibacterial agent with a suitable water vapor permeability, good mechanical properties, and controlled antibiotic release is a promising method for stopping bacterial infection in wound tissue. In this respect, this work aims to prepare novel flexible polymeric hydrogel films via integrating UiO-66 into the polymeric carboxymethyl cellulose (CMC) hydrogel for improving the mechanical and antibiotic release performances. First, we performed a green hydrothermal synthetic method to synthesis UiO-66 and followed by encapsulating Tetracycline (TC) through immersion in its aqueous solution. Also, the casting technique was utilized to integrate different concentrations of the TC-encapsulated UiO-66 (TC@UiO-66, 5% to 15%) in the polymeric CMC matrix (CMC/TC@UiO-66) cross-linked by citric acid and plasticized by glycerol. The release performance showed a low initial burst release with a controlled release over 72 h in the artificial sweat and simulated wound exudate (PBS, pH 7.4) media. The in vitro cytotoxicity and antibacterial activity results revealed a good cytocompatibility toward Human skin fibroblast (HFF-1) cells and a significant activity against both E. coli and S. aureus with 1.3 and 1.7 cm inhibition zone, respectively. The obtained results recommend CMC/TC@UiO-66 films as a potential antibacterial wound dressing.