1.
Org Lett
; 25(13): 2361-2365, 2023 Apr 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-36988968
RESUMEN
An operationally simple and efficient strategy for the synthesis of substituted tetrahydrofurans from readily available cis-butene-1,4-diol is described. A redox-relay Heck reaction is used to rapidly access cyclic hemiacetals that can be directly reduced to afford the corresponding 3-aryl tetrahydrofuran. Furthermore, the hemiacetals can also serve as precursors to a range of disubstituted tetrahydrofurans, including the calyxolane natural products.