RESUMEN
The concentration of organochlorines (OCs) such as organochlorine pesticides and polychlorinated biphenyls were measured in adipose tissue collected from 14 male hippopotami at Mfuwe in the southern part of the Luangwa National Park, Zambia. The samples contained low levels of OCs, and the concentrations of OCs were comparable to or lower than reported for wild herbivores studied in other parts of the world.
Asunto(s)
Tejido Adiposo/química , Artiodáctilos/metabolismo , Residuos de Plaguicidas/análisis , Tejido Adiposo/metabolismo , Animales , Monitoreo del Ambiente/métodos , Hidrocarburos Clorados/análisis , Masculino , Bifenilos Policlorados/análisis , Contaminantes Químicos del Agua/análisis , ZambiaRESUMEN
Hepatic and renal concentrations of the elements arsenic, cadmium, cobalt, copper, lead, manganese, mercury, molybdenum, selenium and zinc were studied in samples collected from hippopotami from the Kafue River in the Kafue National Park and the Luangwa River in the Southern Luangwa National Park in Zambia. There were no significant differences between trace element concentrations in the tissues of the hippopotami taken in the Kafue River and the Luangwa River. The concentrations of copper and other essential elements were similar to those reported in normal domestic and wild ruminants. Judging by the results obtained in this study, pollution from the mining activity around the Kafue River drainage area in the Copperbelt region has not led to any accumulation of elements in tissues of the hippopotami in the Kafue National Park. The trace element concentrations observed may serve as reference for similar future studies on hippopotami.
Asunto(s)
Artiodáctilos/metabolismo , Sedimentos Geológicos/análisis , Minería , Oligoelementos/análisis , Contaminantes Químicos del Agua/análisis , Animales , Cobre/análisis , Monitoreo del Ambiente/métodos , Femenino , Riñón/química , Hígado/química , Masculino , Distribución Tisular , ZambiaRESUMEN
In mammals, copper (Cu) absorption occurs mostly in the small intestine, and some of the Cu transporters involved in its uptake have been characterised. In fish, however, the regions of the gut involved in Cu absorption and the membrane transport mechanisms responsible for gastrointestinal Cu uptake are unknown. Everted gut sacs and isolated perfused intestine of Clarias gariepinus were used to explore Cu absorption (at 22 degrees C). Gut sacs exposed to 100 micromol l(-1) mucosal solution Cu ([Cu](m)) showed that Cu was mostly (70 %) absorbed in the middle and hind intestine. Most of the accumulated Cu was located in the mucosa. In perfused intestines, cumulative Cu absorption from the mucosal solution to the serosal perfusate was greatest at 10 micromol l(-1) [Cu](m) and decreased at higher values of [Cu](m), while tissue accumulation of Cu showed a dose-dependent elevation. Absorption efficiency therefore declined with increasing Cu dose, and basolateral transport was the limiting factor in Cu uptake. Serosal applications of the P-type ATPase inhibitor vanadate (100 micromol l(-1)) or the anion transport inhibitor DIDS (100 micromol l(-1)) caused threefold increases in net Cu uptake (at [Cu](m)=10 micromol l(-1)). The vanadate effect was explained by a reduction in transepithelial potential rather than inhibition of Cu-ATPase, but the DIDS effect was not. Transepithelial potential, water transport and tissue [Cu] were not affected by DIDS, but tissue [K(+)] was elevated. Removal of Cl(-) simultaneously from both the mucosal and serosal solutions caused a 10-fold reduction in the rate of Cu uptake, while removal of Cl(-) from the mucosal solution only completely abolished Cu absorption to the serosal perfusate. Transepithelial potential effects are discussed. We conclude that Cu absorption occurs mostly in the intestine and is normally driven by a basolateral Cu/anion symport that prefers Cl(-).
Asunto(s)
Bagres/metabolismo , Cobre/metabolismo , Ácido 4,4'-Diisotiocianostilbeno-2,2'-Disulfónico/farmacología , Adenosina Trifosfatasas/antagonistas & inhibidores , Animales , Cloruros/metabolismo , Cobre/administración & dosificación , Sistema Digestivo/efectos de los fármacos , Sistema Digestivo/metabolismo , Relación Dosis-Respuesta a Droga , Inhibidores Enzimáticos/farmacología , Epitelio/efectos de los fármacos , Epitelio/metabolismo , Técnicas In Vitro , Absorción Intestinal/efectos de los fármacos , Transporte Iónico/efectos de los fármacos , Potenciales de la Membrana , Perfusión , Vanadatos/farmacologíaRESUMEN
Bilateral duplication of the ceca in an adult chicken was observed. One characteristic in addition to the duplication was excessive enlargement of one cecum, which contained 336 grams of cecal contents. Undeveloped and developed eggs were also retained in the oviduct because of oviductal atresia. There are few reports of anomalies in domestic fowl (1,2,3,5). Most studies of the incidence of abnormalities in domestic fowl have been assessments of case collections. This paper reports a rare congenital abnormality of the ceca in a domestic chicken, unreported before in the literature, together with atresia of the oviduct and retention of undeveloped and developed eggs in the oviduct.
Asunto(s)
Ciego/anomalías , Pollos/anomalías , Animales , Femenino , Oviductos/anatomía & histología , Oviductos/patologíaRESUMEN
Mammary adenocarcinoma was diagnosed in a 3-year-old Landrace sow with prolonged infertility, anorexia and progressive emaciation after parturition. Gross examination confirmed a large tumour in the left anterior mammary gland with metastatic nodules on the pleura and in the parenchyma of lung. Microscopically, the tumour consisted mainly of solid adenomatous proliferations with numerous mitotic figures. Irregular glandular structures, solid nests of polygonal tumour cells without polarity and nests consisting of glandular, cribriform and solid portions were evident in dense fibrous stroma. Immunostaining revealed keratin in the tumour cells.