RESUMEN

The pharmacological properties of 4 derivatives of 11-desoxy-prostaglandins E (uterotonic, luteolytic, hypotensive, anti-inflammatory, diarrhogenic ones and also acute toxicity) were studied. Compound I possessed the uterotonic activity which decreased with an alpha-chain elongation and a radical introduction into a benzene ring. Compounds I and II exhibited the luteotropic properties at low doses and the luteolytic ones at high doses. The compounds under study had the hypotensive activity due to the presence of a benzene ring in a W-chain.

Asunto(s)

Alprostadil/análogos & derivados , Prostaglandinas E Sintéticas/farmacología , Reproducción/efectos de los fármacos , Alprostadil/farmacología , Alprostadil/uso terapéutico , Alprostadil/toxicidad , Animales , Cuerpo Lúteo/efectos de los fármacos , Diarrea/inducido químicamente , Diclofenaco/uso terapéutico , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Edema/tratamiento farmacológico , Femenino , Cobayas , Hipotensión/inducido químicamente , Ratones , Progesterona/sangre , Prostaglandinas E Sintéticas/uso terapéutico , Prostaglandinas E Sintéticas/toxicidad , Conejos , Ratas , Contracción Uterina/efectos de los fármacos