RESUMEN
The endoplasmic reticulum is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis, and provides stringent quality control systems to ensure that the only correctly folded proteins transit to the Golgi and unfolded or misfolded proteins are retained and ultimately degraded. The endoplasmic reticulum stress represents the unfolded protein response to cope with the accumulation of unfolded or misfolded proteins and is required to maintain the functional integrity of the endoplasmic reticulum. The endoplasmic reticulum stress is a fundamental phenomenon which provides a secure protection of the cells from different factors. This stress provides a wide spectrum of physiological roles in diverse developmental and metabolic processes, especially for professional secretory cells with high-level secretory protein synthesis, such as pancreatic beta cells, hepatocytes and osteoblasts and is required throughout the entire life. The endoplasmic reticulum stress and hypoxia are the obligate components of malignant tumor growth, are interconnected and activate angiogenesis via growth and metabolism control. The endoplasmic reticulum stress is mediated by three by three sensor and signaling pathways (PERK, ATF6 and ERN1), besides that blockade one (ERN1) leads to a decrease of tumor growth through suppression of angiogenesis and proliferation. The data concerning the interaction of signaling enzyme ERN1 and pro- and anti-angiogenic gene expressions is analyzed.
Asunto(s)
Estrés del Retículo Endoplásmico , Retículo Endoplásmico/metabolismo , Aparato de Golgi/metabolismo , Neoplasias/irrigación sanguínea , Respuesta de Proteína Desplegada , Animales , Apoptosis , Retículo Endoplásmico/patología , Endorribonucleasas/genética , Endorribonucleasas/metabolismo , Aparato de Golgi/patología , Humanos , Neoplasias/metabolismo , Neoplasias/patología , Neovascularización Patológica , Pliegue de Proteína , Proteínas Serina-Treonina Quinasas/genética , Proteínas Serina-Treonina Quinasas/metabolismo , Transporte de Proteínas , Transducción de SeñalRESUMEN
The article contains the results of investigation on particularities of the ischemic stroke course in patients with atrial fibrillation. Neurological particularities of the ischemic stroke course in patients with atrial fibrillation are characterized with disorders of central hemodynamics, worse neurological status, high mortality. Neuroimaging features of ischemic stroke in patients with atrial fibrillation are similar to those in group without arrhythmia (P > 0.05). Ischemic focus is more frequently localized in left cerebral medium artery in all patients. Significant difference in the level of mean systolic and diastolic blood pressure between groups has not been detected (P > 0.05). The majority of patients with cardioembolic stroke had permanent atrial fibrillation (86.4%).
Asunto(s)
Fibrilación Atrial/complicaciones , Isquemia Encefálica/diagnóstico , Accidente Cerebrovascular/diagnóstico , Anciano , Anciano de 80 o más Años , Antihipertensivos/administración & dosificación , Antihipertensivos/uso terapéutico , Aspirina/administración & dosificación , Aspirina/uso terapéutico , Fibrilación Atrial/fisiopatología , Presión Sanguínea/efectos de los fármacos , Isquemia Encefálica/etiología , Isquemia Encefálica/fisiopatología , Isquemia Encefálica/prevención & control , Femenino , Escala de Coma de Glasgow , Frecuencia Cardíaca/efectos de los fármacos , Hemodinámica/efectos de los fármacos , Hospitalización , Humanos , Masculino , Persona de Mediana Edad , Inhibidores de Agregación Plaquetaria/administración & dosificación , Inhibidores de Agregación Plaquetaria/uso terapéutico , Factores de Riesgo , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/fisiopatología , Accidente Cerebrovascular/prevención & control , Tomografía Computarizada por Rayos XRESUMEN
Medical progress and to optimize the management of health is largely dependent upon the effectiveness of the modernization of education and science. The primary objective in this regard is the creation of a new management model clinics. International experience has confirmed the effectiveness of the cluster approach. Another important development is the transition to single-channel financing, improving the monitoring of the quality of medical care. To solve these problems it is necessary to develop a model management model clinic based on modern technologies of strategic management and information technology, optimizations of economic activity, social monitoring system of public satisfaction with the quality of medical care.
Asunto(s)
Educación Médica Continua/organización & administración , Internado y Residencia/organización & administración , Educación Médica Continua/métodos , Educación Médica Continua/normas , Eficiencia Organizacional , Internado y Residencia/métodos , Internado y Residencia/normas , Evaluación de Programas y Proyectos de Salud , UcraniaRESUMEN
Formation adaptive effect of reflexology is one of the most important non-specific mechanisms of action to ensure implementation of its sacrificial, sanohenetichnoho and preventive effects. Today, basic education in acupuncture should focus on common international standards, including anatomical, physiological, biochemical and biophysical basis. Based on primary specialization of reflexology should be in continuous improvement of the methods of acupuncture in various fields of clinical medicine aggregate of not less than 350 hours, which is usually carried out intermittently for several years.
Asunto(s)
Acupuntura/educación , Educación Médica Continua/organización & administración , Masaje/educación , Reflejoterapia/métodos , Rehabilitación/educación , Educación Médica Continua/métodos , Educación Médica Continua/normas , UcraniaRESUMEN
Cerebrovascular pathology has long moved from the category of a single medical problem in the social problem. Progression of vascular lesions of the brain results in significant disability, and in the later stages interfere with the ability to self-service and significantly reduces the quality of life. The key link is ischemic brain damage, or glutamate cascade, which many researchers believe trigger excitotoxic damage and a major cause of neuronal death. One important component of effective control of the effects of ischemic disorders is complex neuro-cytoprotective therapy. To correct for the effects of both acute and chronic ischemia of the brain need to effectively act in several directions simultaneously, normalizing metabolic changes, eliminating the cytokine imbalance transcription violations, reducing the severity of oxidative stress and excitotoxicity.
Asunto(s)
Fármacos Cardiovasculares/uso terapéutico , Enfermedades Cardiovasculares/tratamiento farmacológico , Trastornos Cerebrovasculares/tratamiento farmacológico , Hipoxia/tratamiento farmacológico , Isquemia/tratamiento farmacológico , Metilhidrazinas/uso terapéutico , Fármacos Cardiovasculares/administración & dosificación , Fármacos Cardiovasculares/efectos adversos , Enfermedades Cardiovasculares/etiología , Enfermedades Cardiovasculares/patología , Circulación Cerebrovascular/efectos de los fármacos , Trastornos Cerebrovasculares/etiología , Trastornos Cerebrovasculares/patología , Metabolismo Energético/efectos de los fármacos , Humanos , Hipoxia/complicaciones , Hipoxia/patología , Isquemia/complicaciones , Isquemia/patología , Metilhidrazinas/administración & dosificación , Metilhidrazinas/efectos adversos , Ensayos Clínicos Controlados Aleatorios como AsuntoRESUMEN
Highlights the experience of the Department of Neurology and Reflexology to organize continuous education process in preparing doctors with specialization reflexology.
Asunto(s)
Acupuntura/educación , Educación Médica Continua/métodos , Masaje/educación , Reflejoterapia/métodos , UcraniaRESUMEN
The study of cellular and molecular processes that underlie the regeneration of nerve tissue is one of the most important problems of modern neuroscience. The solution of this problem is associated with the development of the new methods for the treatment of ischemic stroke. This paper investigated one of the key regulators of angio- and neurogenesis--vascular endothelial growth factor (VEGF). We stadied changes in the expression of VEGF genes under ischemia and hypoxic conditions in glioma cell lines U87 and its dependence on the ERN1 gene function. We found that the expression of VEGF genes in glioma cell lines U87 is significantly changed under hypoxia and ischemic conditions. Its expression depends upon the blockade of the ERN1 gene function.
Asunto(s)
Expresión Génica , Isquemia/genética , Neovascularización Patológica/genética , Neurogénesis/genética , Factor A de Crecimiento Endotelial Vascular/genética , Técnicas de Cultivo de Célula , Hipoxia de la Célula/genética , Línea Celular Tumoral , Medios de Cultivo , Endorribonucleasas/genética , Endorribonucleasas/metabolismo , Glioma/patología , Glucosa/deficiencia , Glutamina/deficiencia , Humanos , Proteínas de la Membrana/genética , Proteínas de la Membrana/metabolismo , Oxígeno/metabolismo , Proteínas Serina-Treonina Quinasas/genética , Proteínas Serina-Treonina Quinasas/metabolismo , Reacción en Cadena en Tiempo Real de la PolimerasaRESUMEN
Rehabilitation of stroke patients, is a complex chain of consistently conducted medical and social measures aimed at rehabilitation, health or possible adaptation to self-service in the presence of a persistent neurological defect. Already in acute stroke patient needs not only to drug therapy and care, but also in the emotional and psychological support for the type of "cautious optimism." It should be explained to the patient a temporary, reversible nature of its existing motor and other violations. With relatives patient should discuss the real situation, prognosis, rehabilitation opportunities, the need for hospitalization or appropriate treatment at home, put them in front of clear objectives for the near future. Activity and the amount of rehabilitation expanded in young children with satisfactory prognosis, consideration being given to their professional and social status.
Asunto(s)
Hipocinesia/terapia , Modalidades de Fisioterapia , Rehabilitación de Accidente Cerebrovascular , Ejercicios Respiratorios , Humanos , Hipocinesia/etiología , Masaje , Accidente Cerebrovascular/complicaciones , Factores de Tiempo , Vibración/uso terapéuticoRESUMEN
UNLABELLED: In the article the educational and pedagogical and organizational measures designed and implemented in practice staff of the Department of Neurology and reflexology to improve the training of doctors cycle "general practice family medicines". OBJECTIVE: To optimize teaching process for doctors neurology "General practice - family medicine". We recommend using the following methods for diagnosing the level of training of cadets: Control of practical skills--the ability to explore the neurological status and interpret it in different neurological diseases, questionnaires, computer tests, solving situational problems.
Asunto(s)
Educación Médica/organización & administración , Medicina Familiar y Comunitaria/educación , Médicos Generales/educación , Neurología/educación , Rehabilitación/educación , Enseñanza/métodos , Educación Médica/normas , UcraniaRESUMEN
The Carpal tunnel syndrome is the most frequent entrapment neuropaphy of human. The Article is dedicated to diagnostics and conservative treatment this pathology. The early diagnostics and in time fixed treatment prevents the progress of the disease, raises the quality of life and allows to avoid surgical procedure. Big attention is given acupuncture reflexotherepy and infrared latherotherepy, which use raises the quality of the therapeutic influences.
Asunto(s)
Síndrome del Túnel Carpiano/diagnóstico , Síndrome del Túnel Carpiano/terapia , Acupuntura/métodos , Puntos de Acupuntura , Corticoesteroides/administración & dosificación , Corticoesteroides/uso terapéutico , Antiinflamatorios no Esteroideos/administración & dosificación , Antiinflamatorios no Esteroideos/uso terapéutico , Síndrome del Túnel Carpiano/epidemiología , Terapia Combinada , Diagnóstico Diferencial , Quimioterapia Combinada , Electromiografía , Humanos , Terapia por Luz de Baja Intensidad/métodos , Modalidades de Fisioterapia , Reflejoterapia/métodosRESUMEN
The article raises the question of integrated approaches to the treatment of multiple sclerosis, depending on the phase of the disease, type of course and comorbidity. The features of rehabilitation in this disease, discussed the feasibility of reflexology techniques in complex medical and rehabilitation measures.
Asunto(s)
Esclerosis Múltiple/terapia , Reflejoterapia/métodos , Adyuvantes Inmunológicos/administración & dosificación , Adyuvantes Inmunológicos/uso terapéutico , Corticoesteroides/administración & dosificación , Corticoesteroides/uso terapéutico , Adulto , Terapia Combinada , Quimioterapia Combinada , Femenino , Humanos , Masculino , Esclerosis Múltiple/inmunología , Esclerosis Múltiple/prevención & control , Índice de Severidad de la EnfermedadRESUMEN
Poor health-care system of Ukraine was the impetus for radical reform of the industry through the introduction of family medicine as a primary care for population. This led to the necessity for rapid training of the specialists and the development of special training programs in medical universities. Teachers have a problem to form a work model of general practitioners in severe diagnostic cases, which is especially important in the case of septic lesions of the nervous system.
Asunto(s)
Infecciones del Sistema Nervioso Central , Educación Médica Continua/métodos , Medicina Familiar y Comunitaria/educación , Médicos Generales/educación , Médicos de Familia/educación , Infecciones del Sistema Nervioso Central/diagnóstico , Infecciones del Sistema Nervioso Central/terapia , Curriculum , Educación Médica Continua/legislación & jurisprudencia , Educación Médica Continua/normas , Humanos , Programas Nacionales de Salud , Enseñanza , UcraniaRESUMEN
Epidemiology information which testify to prevalence syndrome of chronic ustalostti (SV) is resulted in the article, and from some data this diagnosis is covered at more than 20% patients which carried neyroinfection. SV meets more frequent only in age 40-59, thus for women a disease is marked in 4 times more frequent, than for men. Today etiology of disease remains unknown, but the value of genetic, immunological factors, pathogens, neurogenic violations and features of feed is examined. Possibility of infectious etiology SV causes considerable interest of researchers, but at first this syndrome was examined as a sharp viral infection, where the most reliable exciter is consider the virus of Epshteyna-barr. Using of intravenous introduction of globulin for SV carries experimental character and grounded on a hypothesis about immunological or infectious etiology of this disease.
Asunto(s)
Enfermedades Virales del Sistema Nervioso Central/complicaciones , Infecciones por Virus de Epstein-Barr/complicaciones , Síndrome de Fatiga Crónica , Enfermedades Virales del Sistema Nervioso Central/virología , Infecciones por Virus de Epstein-Barr/virología , Síndrome de Fatiga Crónica/diagnóstico , Síndrome de Fatiga Crónica/epidemiología , Síndrome de Fatiga Crónica/etiología , Síndrome de Fatiga Crónica/terapia , Humanos , PrevalenciaRESUMEN
Diagnostics of neuropathy pain is presented in the article, where most essential are methods of clinical estimation with the use of questionnaires and scales for verification and quantitative estimation of pain. The neurological inspection of patients with suspicion on neuropathy pain must plug in itself of the motive, sensory and vegetative phenomena with the purpose of authentication of all signs of neurological dysfunction. If on a background immunotherapy it is not succeeded fully a pain syndrome preparations of the first row, setting of combined pharmacotherapy allows to promote efficiency of treatment at the less dosages of preparations and reduce the risk of development of by-effects.
Asunto(s)
Aminas/uso terapéutico , Analgésicos/uso terapéutico , Ácidos Ciclohexanocarboxílicos/uso terapéutico , Neuralgia/tratamiento farmacológico , Tiamina/análogos & derivados , Ácido gamma-Aminobutírico/uso terapéutico , Adulto , Anciano , Aminas/administración & dosificación , Aminas/efectos adversos , Analgésicos/administración & dosificación , Analgésicos/efectos adversos , Ácidos Ciclohexanocarboxílicos/administración & dosificación , Ácidos Ciclohexanocarboxílicos/efectos adversos , Esquema de Medicación , Quimioterapia Combinada , Femenino , Gabapentina , Humanos , Masculino , Persona de Mediana Edad , Neuralgia/diagnóstico , Neuralgia/etiología , Dimensión del Dolor , Tiamina/administración & dosificación , Tiamina/efectos adversos , Tiamina/uso terapéutico , Resultado del Tratamiento , Ucrania , Ácido gamma-Aminobutírico/administración & dosificación , Ácido gamma-Aminobutírico/efectos adversosRESUMEN
Clinical estimation of the patient with suspicion of stroke is not quite investigated problem yet. The article contains modern data on aspects of differential diagnosis of stroke and stroke-like conditions in acute period. Neurological symptoms in acute ischemic stroke and in somatic diseases which imitate clinical picture of stroke have been analysed and compared. The particularities of atypical ischemic stroke pathogenesis have been discussed. The initial clinical evaluation of the patients can be optimized, that is of great importance in cases of stroke management.
Asunto(s)
Isquemia Encefálica/diagnóstico , Accidente Cerebrovascular/diagnóstico , Accidente Cerebrovascular/etiología , Enfermedad Aguda , Isquemia Encefálica/complicaciones , Diagnóstico Diferencial , HumanosRESUMEN
The current work covers the question of the additional methods of examination in neurology. The special accent is put on electroneuromyography (ENMG). The actuality and importance of knowledge of ENMG basic principles for the neurologists are shown. Neurophysiological substantiation of ENMG, its diagnostic value, indications and contra-indication to realization are presented.
Asunto(s)
Electromiografía/métodos , Examen Neurológico/métodos , Enfermedades Neuromusculares/diagnóstico , Electromiografía/instrumentación , Humanos , Examen Neurológico/instrumentaciónRESUMEN
Syndrome of Giyena-Barre can arise up in any age, in different regions, for men more frequent, than for women. There are descriptions of clinical supervisions of syndrome in domestic literature, combining with the defeat of the nervous system as a result of different pathogens which are procatarxiss in the start of mechanisms of immune attack on the albumens of mielina. However this disease continues to remain one of most heavy, requiring neyroreanimacionnykh measures, that causes the necessity of development of new methods of treatment in same queue.
Asunto(s)
Síndrome de Guillain-Barré/diagnóstico , Síndrome de Guillain-Barré/terapia , Adulto , Cuidados Críticos , Electromiografía , Femenino , Humanos , Examen Neurológico , Plasmaféresis , Respiración Artificial , Resultado del TratamientoAsunto(s)
Biomarcadores/análisis , Isquemia Encefálica/diagnóstico , Accidente Cerebrovascular/diagnóstico , Enfermedad Aguda , Isquemia Encefálica/complicaciones , Isquemia Encefálica/genética , Isquemia Encefálica/metabolismo , Marcadores Genéticos , Humanos , Valor Predictivo de las Pruebas , Pronóstico , Accidente Cerebrovascular/etiología , Accidente Cerebrovascular/genética , Accidente Cerebrovascular/metabolismoRESUMEN
Single photon emission computed tomography (SPECT) is a highly informative method of functional neuroimaging with high diagnostic potential for some neurological disorders. We used this method in diagnostics of specification of lesion localization, choosing of treatment tactics for chronic cerebral blood circulation disorders and evaluation of cavinton effect. The positive effect of the drug on cerebral hemoperfusion is confirmed.