RESUMEN

Geranylated coumarins named mammeasins G-J (1-4) were isolated from the methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) originating in Thailand. Their structures were established based on detailed spectroscopic analyses. The isolates, including previously reported coumarin constituents (5-28), exhibited anti-proliferative activities against human carcinoma cell lines HSC-2, HSC-4, MKN-45, and MCF-7. Mammeasin A (7, IC50 = 13.6 µM) and surangin B (15, 15.2 µM), both consisting of the geranyl group, were found to show relatively strong activities against HSC-4 cells and their mechanisms of action were found to involve apoptotic cell death.

Asunto(s)

Antineoplásicos Fitogénicos/farmacología , Cumarinas/farmacología , Neoplasias Gastrointestinales/patología , Mammea/química , Antineoplásicos Fitogénicos/aislamiento & purificación , Apoptosis , Carcinoma/tratamiento farmacológico , Carcinoma/patología , Línea Celular Tumoral , Cumarinas/aislamiento & purificación , Flores/química , Neoplasias Gastrointestinales/tratamiento farmacológico , Humanos , Estructura Molecular , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Plantas Medicinales/química , Tailandia