RESUMEN

Three new neoclerodane diterpenoids, salvinorins D-F (4-6), have been isolated from the leaves of Salvia divinorum. The structures were elucidated by chemical and spectroscopic methods, particularly 1D and 2D NMR. A simplified isolation method using chromatography on activated carbon also gave improved yields of the controlled substance salvinorin A (1) and of salvinorin C (3).

Asunto(s)

Diterpenos/aislamiento & purificación , Salvia/química , Acetilación , Animales , Diterpenos/química , Diterpenos/farmacología , Diterpenos de Tipo Clerodano , Conducta Alimentaria/efectos de los fármacos , México , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Spodoptera/efectos de los fármacos , Tenebrio/efectos de los fármacos