RESUMEN

The low incidence of vincristine-induced peripheral neuropathy (VIPN) in Kenyan children may result from low vincristine exposure. We studied vincristine exposure in Kenyan children and dose-escalated in case of low vincristine exposure (NCT05844670). Average vincristine exposure was high. Individual vincristine exposure was assessed with a previously developed nomogram. A 20% dose increase was recommended for participants with low exposure and no VIPN, hyperbilirubinemia, or malnutrition. None of the 15 participants developed VIPN. Low vincristine exposure was seen in one participant: a dose increase was implemented without side effects. In conclusion, the participants did not develop VIPN despite having high vincristine exposure.

Asunto(s)

Estudios de Factibilidad , Enfermedades del Sistema Nervioso Periférico , Vincristina , Humanos , Vincristina/efectos adversos , Vincristina/administración & dosificación , Femenino , Masculino , Kenia , Preescolar , Niño , Enfermedades del Sistema Nervioso Periférico/inducido químicamente , Lactante , Antineoplásicos Fitogénicos/efectos adversos , Antineoplásicos Fitogénicos/administración & dosificación , Neoplasias/tratamiento farmacológico , Estudios de Seguimiento , Adolescente