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Background In this study, we aimed to determine the causes of emergency department (ED) visits by end-stage kidney disease (ESKD) patients on maintenance hemodialysis (MHD) in Karachi, Pakistan. Methodology We conducted a cross-sectional study that included 194 visits of ESKD patients on MHD aged ≥18 years of both genders presenting at the ED of The Kidney Centre Postgraduate Training Institute, Karachi, Pakistan between February 2021 and May 2021. The study investigated the causes behind ED visits. Frequencies were calculated for categorical variables, and a bar graph was used for the graphical representation of the causes. Results In total, 194 visits included 151 patients of whom 88 (58.3%) were males while 63 (41.7%) were females, with a mean age of 51.68 ± 15.8 years. The most common comorbidity among the ED visits was hypertension 182 (93.8%). The majority of the visits 129 (66.5%) were undergoing regular three dialysis sessions per week, 101 (52.1%) were registered for MHD at our Institute, and 69.1% of visits reported arteriovenous fistula (AVF) as the current access for hemodialysis. Around 111 (57.2%) of the visits had infection-related complications, followed by electrolyte abnormalities 74 (38.1%), cardiovascular 53 (27.3%), and pulmonary complications 41 (21.1%). Overall, 19 (9.8%), 16 (8.2%), and 14 (7.2%) patients reported access-related, neurological, and gastrointestinal complications, respectively. Conclusions Infection-related complications are a significant cause of ED visits among ESKD patients, followed by electrolyte abnormalities and systemic complications, many of which are related to the existing comorbid conditions. Risk identification of preventable causes and surveillance of existing comorbidities would help mitigate ED visits among ESKD patients.
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OBJECTIVES: To estimate the frequency of intradialytic hypertension (IDH) in our centre as per the definition suggested by Kidney Disease: Improving Global Outcomes (KDIGO). METHODS: A cross-sectional study was conducted at the dialysis department of The Kidney Centre Post Graduate Training Institute (PGTI) Karachi, Pakistan from August 2021 to October 2021 among 263 end-stage kidney disease (ESKD) patients on maintenance hemodialysis (MHD) aged ≥ 18 years of both genders. The study outcome was the frequency of IDH as per the latest KDIGO suggested definition i.e., systolic blood pressure (SBP) rise of > 10 mm Hg from pre- to post-dialysis within the hypertensive range in at least four out of six consecutive dialysis treatments. Frequencies (%) and mean (±SD) were calculated for categorical and continuous variables respectively, using SPSS version 21 (IBM Corp., Armonk, NY, USA). RESULTS: Among 263 patients, the mean age was 51.02 (±14.1) years and 56.3% were males. Around 30.8% of patients were dialysis-dependent for 1.1 to three years. The most common comorbidity was hypertension (88.6%). Standard dialysate calcium of 3mEq/l was received by 91.6% of study participants. About 78.7% of patients were using antihypertensive(s), out of which 85.5% were compliant and 37.6% were using a single antihypertensive. The most common antihypertensive in use was beta-blockers (78.3%). Around 16% of patients were found to have IDH. Age of the patients was significantly associated with IDH (p=0.038). The majority of the patients with IDH were those who were taking anti-hypertension medications as compared to the patients who were not taking them (p <0.004). Interdialytic weight gain was not a significant predictor for IDH. CONCLUSION: The frequency of IDH was 16% according to the latest suggested KDIGO definition. This is much lower than regional and global estimates according to earlier definitions. There is a dire need to establish a standardized definition of IDH in guidelines to diagnose, manage and compare data. Also, the association of IDH with fluid overload is not found in our study which emphasizes the need to evaluate other causative factors.