RESUMEN
PURPOSE: Ewing sarcoma (ES) is a relatively rare, highly malignant tumor of the musculoskeletal system. It is the second most common malignant bone tumor in children and adolescents in the age group of 5 to 20 years. The aim of this study was to identify the treatment outcomes of pediatric patients with ES in Sulaimani governorate, Iraq. PATIENTS AND METHODS: This was a retrospective study that reviewed the medical records of pediatric patients with ES who were managed between 2009 and 2015, with follow-up until late 2017. Patient- and tumor-related factors were correlated with clinical outcomes. RESULTS: A total of 31 pediatric patients with ES were included in this study. All the patients received chemotherapy and radiotherapy, whereas only 14 patients underwent surgical resection and just eight had free surgical margins. The median age at diagnosis was 13 years, 58% were male, and 42% were female. The presenting symptoms at diagnosis were mostly pain (67.7%) and palpable mass (25.8%). The primary tumor was located in the extremities (51.6%), the thoracic cage (19.4%), the pelvis (16.1%), and the lumbar vertebrae (12.9%). Approximately two thirds of the patients (61.3%) had localized disease at the time of presentation. The 5-year overall survival was 19%, and the 5-year recurrence-free survival was 34%. CONCLUSION: Clinical outcomes of ES in pediatric patients in our war-torn nation, Iraq, are still markedly inferior to the published outcomes from stable, developed nations. Additional large and multicenter national studies are required. Diagnostic and therapeutic measures need improvement, and multidisciplinary and comprehensive cancer-integrated approaches are vital for better outcomes.
Asunto(s)
Neoplasias Óseas/terapia , Sarcoma de Ewing/terapia , Exposición a la Guerra/estadística & datos numéricos , Adolescente , Neoplasias Óseas/mortalidad , Neoplasias Óseas/patología , Quimioradioterapia , Terapia Combinada , Femenino , Humanos , Irak/epidemiología , Masculino , Estudios Retrospectivos , Sarcoma de Ewing/mortalidad , Sarcoma de Ewing/patología , Procedimientos Quirúrgicos Operativos/estadística & datos numéricos , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
INTRODUCTION: Cancer prevalence and geriatric patients (GP) are increasing and about half of the patients with cancer will be offered radiotherapy (RT). Addressing GP and their RT needs is an important issue in order to understand this heterogeneous group of patients. MATERIALS AND METHODS: A descriptive cross-sectional study, using a convenience sample from Sulaimani city's inhabitants, aged 70-year and more, who were treated with RT at the only city's RT center, Zhianawa Cancer Center (ZCC), in 2015. RESULTS: 153 patients' charts were reviewed. GP represented 20% of the patients referred to ZCC. Male: Female ratio was 3:1. One third presented with distant metastases, and 46% were treated with curative intent versus 54% with palliative intent. 94% completed the planned sessions of the curative RT vs 90% of the palliative RT. 23% of GP who were referred for RT didn't receive it. 9% got interruptions during RT course. 10% of GP living >40â¯km away from the treatment center refused treatment. Mean time interval between the date of referral and the date of starting treatment in the palliative setting was 19â¯days. Only 41% of patients with curative setting had regular follow-up. CONCLUSIONS: Being the 1st study in this regard in a war-torn nation, Iraq, our results demonstrated that GP is a sizable group of ZCC patients and that RT is a valuable modality in GP cancer treatment. "Age per se" is not a factor to avoid this modality when there is an indication to use it. Longer distance to reach the center was a challenge in some of our GP. Due to inadequate number of RT machines, GP have to wait long time before getting their RT, even for palliative purposes. Further studies in this field are warranted.