RESUMEN

A 32-year-old male patient was admitted at our department presenting microhematuria and full nephrotic syndrome in April 1995. A percutaneous kidney biopsy showed a stage I-lI membranous nephropathy and an eight-week course with oral prednisone was initiated without response. Then, oral cyclosporine A (3.5 mg/kg/day) was given and after 5 weeks of treatment, remission of the nephrotic syndrome was observed but creatinine raised to 1.6 mg/dl, normalizing after reducing the dose of cyclosporine A. We discuss the settings, prognostic and therapeutic alternatives for idiopathic membranous nephropathy.

Asunto(s)

Ciclosporina/efectos adversos , Glomerulonefritis Membranosa/complicaciones , Inmunosupresores/efectos adversos , Enfermedades Renales/inducido químicamente , Síndrome Nefrótico/tratamiento farmacológico , Adulto , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Antihipertensivos/uso terapéutico , Inhibidores de la Calcineurina , Bloqueadores de los Canales de Calcio/uso terapéutico , Creatinina/sangre , Ciclosporina/uso terapéutico , Quimioterapia Combinada , Humanos , Hipercolesterolemia/complicaciones , Hipercolesterolemia/tratamiento farmacológico , Hipertensión/complicaciones , Hipertensión/tratamiento farmacológico , Hipolipemiantes/uso terapéutico , Inmunosupresores/uso terapéutico , Lisinopril/uso terapéutico , Lovastatina/uso terapéutico , Masculino , Síndrome Nefrótico/etiología , Prednisona/uso terapéutico , Recurrencia , Verapamilo/uso terapéutico