RESUMEN
Embolisation with allogenic bone marrow administered into the femoral vein was performed in 12 dogs, anaesthetized and heparinized. The ECG and ventricular, aortic and pulmonary artery pressures were recorded by catheterization. From these the following parameters were calculated: cardiac output (CO), by thermodilution; modified cardiac index (CO/M); systolic cardiac index (CO/M/F); work performance of right and left ventricle (Wr, W1); ejection indices of right and left ventricle (Wr/M/F, W1/M/F); first derivative of left ventricular pressure (dp/dt) max and the total pulmonary (TPR) and systemic (TSR) resistance. All parameters were studied also in 12 control ( nonembolized ) dogs. The most significant haemodynamic changes found in the embolized group were as follows: 1) a lowering of the end-diastolic pressure in the left ventricle, of the W1 and W1/M/F, of the Wr with a slight augmentation in the 15th min after embolisation, Wr/M/F and CO/M/F; 2) a rise in heart rate, an augmentation of TPR during the first minutes of the experiment, and of TSR at the end of the experiment.
Asunto(s)
Médula Ósea , Hemodinámica , Embolia Pulmonar/fisiopatología , Animales , Trasplante de Médula Ósea , Gasto Cardíaco , Modelos Animales de Enfermedad , Perros , Vena Femoral , Embolia Pulmonar/etiología , Volumen Sistólico , Trasplante Homólogo , Resistencia Vascular , Presión VenosaAsunto(s)
Volumen Cardíaco , Termodilución , Animales , Perros , Humanos , Matemática , Termodilución/métodosRESUMEN
The effect of lipiodol injected into the pulmonary artery on blood pressure in pulmonary artery and thoracic aorta in dogs. Acta Physiol. Pol. 1977, 28 (2): 143--151. The purpose of the experiments, carried out on 10 anaesthetized dogs, was to trace changes in pressure in aorta and pulmonary artery within 2 hours after injection of lipiodol Ultra-Fluide into the pulmonary artery of dogs. In individual experiments a gradual fall, rise or maintenance of normal pressure was found in the aorta. Pressure changes in the pulmonary artery were similar. Statistical analysis failed to demonstrate any significant correlation between the pressure in the aorta or in the pulmonary artery and the time of measurements of these pressures during the two-hour experiment.