1.
Org Lett
; 23(16): 6305-6310, 2021 Aug 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34378945
RESUMEN
The configurational instability of allenyl copper reagents is unveiled. An experimental study highlights the crucial role of Li+ and of the reaction temperature in the control of the configurational stability of allenyl copper reagents. A judicious choice of the reaction conditions allows efficient dynamic kinetic resolution processes and gives a one-pot access to homopropargylic alcohols or amines bearing up to four contiguous defined stereogenic centers.