RESUMEN
Objective Survivin is a member of inhibitors of apoptosis proteins family. There are not data about the association between mortality of septic patients and blood survivin concentrations. Therefore, the objective of this study was to determine whether exist that association. Design Observational and prospective study. Setting Three Spanish Intensive Care Units. Patient Patients with sepsis or septic shock according to Sepsis-3 Consensus criteria. Interventions Serum survivin concentrations were determined at moment of sepsis diagnosis. Main variable of interest Mortality at 30 days. Results A total of 204 patients were included in the study, of which 75 (36.8%) died in the first 30 days. Lower age (p<0.001), serum lactic acid levels (p=0.001), rate of septic shock (p=0.001) and SOFA (p<0.001), and higher serum survivin levels (p=0.001) exhibited surviving (n=129) than non-surviving patients (n=75). We found in multiple logistic regression analysis an association between serum survivin concentrations and mortality independently of SOFA, lactic acid, age, INR, activated partial thromboplastin time (aPTT) and empiric antimicrobial treatment adequate (OR=0.968; 95% CI=0.9460.990; p=0.005), and also independently of APACHE-II, lactic acid, platelet, INR, aPTT and empiric antimicrobial treatment adequate (OR=0.966; 95% CI=0.9430.989; p=0.004). Conclusions There is an association between septic patient mortality and low blood survivin concentrations (AU)
Objetivo Survivina es un miembro de la familia de proteínas inhibidoras de apoptosis. No existen datos sobre la asociación entre la mortalidad de los pacientes sépticos y las concentraciones de survivina en sangre. Por tanto, el objetivo de este estudio fue determinar si existe esa asociación. Diseño Estudio observacional y prospectivo. Ámbito Tres Unidades de Cuidados Intensivos españolas. Pacientes Pacientes con sepsis o shock séptico según criterios del Consenso Sepsis-3. Intervenciones Se determinaron las concentraciones séricas de survivina en el momento del diagnóstico de la sepsis. Variable de interés principal Mortalidad a los 30 días. Resultados Un total de 204 pacientes se incluyeron en el estudio, 75 (36,8%) de los cuales fallecieron en los primeros 30 días. Menor edad (p<0,001), niveles séricos de ácido láctico (p=0,001), tasa de shock séptico (p=0,001) y SOFA (p<0,001), y mayores niveles de survivina en suero (p=0,001) exhibieron los pacientes supervivientes (n=129) en comparación con los fallecidos (n=75). El análisis de regresión logística múltiple mostró una asociación entre las concentraciones séricas de survivina y la mortalidad independientemente del SOFA, ácido láctico, edad, INR, tiempo de tromboplastina parcial activada (aPTT) y tratamiento antimicrobiano empírico adecuado (OR=0,968; IC 95%=0,946-0,990; p=0,005), y también independientemente del APACHE-II, ácido láctico, plaquetas, INR, aPTT y tratamiento antimicrobiano empírico adecuado (OR=0,966; IC 95%=0,943-0,989; p=0,004). Conclusiones Existe una asociación entre la mortalidad de los pacientes sépticos y las concentraciones bajas de survivina en sangre (AU)
Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Anciano , Survivin/sangre , Sepsis/sangre , Sepsis/mortalidad , Estudios Prospectivos , Biomarcadores/sangre , Curva ROCRESUMEN
OBJECTIVE: Survivin is a member of inhibitors of apoptosis proteins family. There are not data about the association between mortality of septic patients and blood survivin concentrations. Therefore, the objective of this study was to determine whether exist that association. DESIGN: Observational and prospective study. SETTING: Three Spanish Intensive Care Units. PATIENTS: Patients with sepsis or septic shock according to Sepsis-3 Consensus criteria. INTERVENTIONS: Serum survivin concentrations were determined at moment of sepsis diagnosis. MAIN VARIABLE OF INTEREST: Mortality at 30 days. RESULTS: A total of 204 patients were included in the study, of which 75 (36.8%) died in the first 30 days. Lower age (p<0.001), serum lactic acid levels (p=0.001), rate of septic shock (p=0.001) and SOFA (p<0.001), and higher serum survivin levels (p=0.001) exhibited surviving (n=129) than non-surviving patients (n=75). We found in multiple logistic regression analysis an association between serum survivin concentrations and mortality independently of SOFA, lactic acid, age, INR, activated partial thromboplastin time (aPTT) and empiric antimicrobial treatment adequate (OR=0.968; 95% CI=0.946-0.990; p=0.005), and also independently of APACHE-II, lactic acid, platelet, INR, aPTT and empiric antimicrobial treatment adequate (OR=0.966; 95% CI=0.943-0.989; p=0.004). CONCLUSIONS: There is an association between septic patient mortality and low blood survivin concentrations.
Asunto(s)
Antiinfecciosos , Sepsis , Choque Séptico , Humanos , Estudios Prospectivos , Pronóstico , Ácido LácticoRESUMEN
INTRODUCTION: The physiopathology of osteoradionecrosis (ORN) is linked to vascular and cellular aspects of bone physiology. The authors had for aim to check whether the transposition of non-irradiated tissues could repair vascular and bone lesions. MATERIAL AND METHOD: A retrospective study was made from 1992 to 2002 on all patients operated for a mandibular ORN (59 patients). The reconstructions performed with a bone flap (42%), bone composite flap (34%), periosteal free flap (14%), cutaneous flap (4%), or muscular flap (5%) were assessed. The radiological and clinical results and the effect of re-vascularization were analyzed. RESULTS: A skin paddle was required in 47% of cases, impairing dental rehabilitation. The bone flap had to be osteotomized in 25% of iliac flaps, and 75% of fibula flaps. The free flap reconstruction had a 90% success rate. Complications were observed in 60% of cases and were more frequent when the stage was higher. The analysis of the surgical technique allowed determining its interest. DISCUSSION: The analysis of results showed the feasibility of this technique in irradiated tissues. The iliac bone free flap was the best solution taking into consideration the shape, bone volume and vestibular morphology. The osteo-induction by a non-irradiated tissue transplantation was demonstrated clinically and radiologically.
Asunto(s)
Mandíbula/irrigación sanguínea , Enfermedades Mandibulares/cirugía , Osteorradionecrosis/cirugía , Colgajos Quirúrgicos/irrigación sanguínea , Procedimientos Quirúrgicos Vasculares/métodos , Adulto , Anciano , Trasplante Óseo , Humanos , Mandíbula/cirugía , Persona de Mediana Edad , Procedimientos de Cirugía Plástica/métodos , Estudios Retrospectivos , Trasplante de PielRESUMEN
Mediatisation of a scientific event could be neither controlled, nor verifiable. The experience which has been lived through the first worldwide allotransplantation of composite tissues of the face confirms that the actors of a surgical innovation are not the owners. Because there is neither confidentiality nor possible patent. Curiously the scientific world, providing with a sharing ethic, which rightly privileges the free spreading of knowledge in the way that most people could benefit of it. Obviously it is made without denied controversy, for truth as purpose. This scientific word that way joins the media one, with a specific ethic of the duty of information, but also interested in mercantile preoccupations quick to cultivate controversy not to enlighten this truth but to better sell pictures or papers. Than the author should only sustain this instrumentation which could certainly flatter him, and from which he could used, but in reality that paralysed him a little to go on in serenity with his shadow worker way.
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Trasplante Facial/ética , Donantes de Tejidos , HumanosRESUMEN
Vascular anomalies are a complex pathological group. They are especially difficult to study because of confusion in the terminology used. The classification developed by the ISSVA (International Society for the Study of Vascular Anomalies) now allows using a common scientific language. The classification is based on clinical, radiological, hemodynamic, and histological arguments. There are two groups of lesions: vascular tumors and vascular malformations. Vascular tumors are associated to vascular proliferation. They are called hemangioma and can be infantile or congenital. Vascular malformations are associated to vessels with morphologic anomalies. They are classified according to the distorted vessel type, capillary, venous, lymphatic, and arteriovenous). Such a classification has many implications. It is a guide for the orientation of radiological exams and treatment of vascular anomalies. The management of these anomalies is still difficult and must involve an interdisciplinary approach.
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Malformaciones Arteriovenosas/clasificación , Vasos Sanguíneos/anomalías , Hemangioma/clasificación , Neoplasias Vasculares/clasificación , Malformaciones Arteriovenosas/terapia , Anomalías Cardiovasculares/clasificación , Anomalías Cardiovasculares/terapia , Clasificación , Hemangioma/terapia , Humanos , Terminología como Asunto , Neoplasias Vasculares/terapiaRESUMEN
INTRODUCTION: Tuberculosis remains an important public health problem in France. After a certain decline, its incidence has remained unchanged since 1990. 30% of tuberculosis cases are extra-pulmonary form, most of them concern nodes especially in cervical areas. CASE REPORT: This case of submandibular tuberculosis illustrates diagnostic and therapeutic difficulties. DISCUSSION: There are few clinical signs or laboratory clues suggestive of tuberculosis, however a surgery cannot be avoided and must be performed in combination with antituberculosis chemotherapy.
Asunto(s)
Enfermedades de la Glándula Submandibular/diagnóstico , Tuberculosis Bucal/diagnóstico , Antituberculosos/administración & dosificación , Antituberculosos/uso terapéutico , Terapia Combinada , Diagnóstico Diferencial , Etambutol/administración & dosificación , Etambutol/uso terapéutico , Femenino , Humanos , Isoniazida/administración & dosificación , Isoniazida/uso terapéutico , Persona de Mediana Edad , Pirazinamida/administración & dosificación , Pirazinamida/uso terapéutico , Rifampin/administración & dosificación , Rifampin/uso terapéutico , Enfermedades de la Glándula Submandibular/cirugía , Tuberculosis Bucal/cirugíaRESUMEN
El asma bronquial es una enfermedad respiratoria crónica, con una importante repercusión en la saludinfantil, y que genera una apreciable alteración del ritmo vital de las familias. Sobre la base de que la atención primaria es el marco ideal para la atención y seguimiento de este grupo de pacientes, proponemos untaller educativo desarrollado por una pediatra y una farmacéutica de atención primaria, como un trabajoasistencial coordinado y planteado para enfocar la educación desde una doble perspectiva: Los conocimientos básicos sobre el asma y su tratamiento: qué es, qué son los bronquios y los pulmonesy cómo les afecta el asma, cuáles son las medidas principales de evitación de alérgenos, cuáles son los síntomas habituales, cómo reconocer y tratar una crisis, y las diferencias de actuación y utilización entre losantinflamatorios y los broncodilatadores. El entrenamiento necesario en las habilidades precisas para la utilización correcta de los dispositivos deinhalación y el manejo de los medidores de flujo espiratorio máximo domiciliario, aspecto imprescindiblepara el entrenamiento de los pacientes en el empleo de los planes de autocontrol y autotratamiento.En el artículo se expone detalladamente la estrategia seguida para el desarrollo de este taller educativo, dirigido a obtener un buen control de la enfermedad, evitando las limitaciones en la vida cotidiana y mejorando la calidad de vida de los pacientes a través de la educación sanitaria
Bronchial asthma is a chronic respiratory disease that has a considerable impact on childhood health andproduces changes in the vital rhythm of the family that are by no means insignificant. Assuming that PrimaryCare is the ideal setting for the management and follow-up of this patient population, we propose aneducational workshop, developed by a primary care pediatrician and pharmacist as a coordinated publichealth effort, and designed to focus on education from a dual perspective: Basic knowledge concerning asthma and its treatment: what it is, what the bronchi and lungs are andhow they are affected by asthma, what can be done to avoid allergens, what are the usual symptoms, how torecognize and treat an attack, and the differences between anti-inflammatory agents and bronchodilators interms of procedure and utilization. The necessary training in the proper use of inhalation devices and the management of home peak expiratoryflow measurements, an aspect that is indispensable for training patients in the application of selfmonitoringand self-treatment plans.The article describes in detail the strategy employed to develop this educational workshop, aimed at maintaininggood control of the disease, avoiding limitations to daily activities and improving the quality of life ofthe patients through health education
Asunto(s)
Humanos , Masculino , Femenino , Niño , Educación del Paciente como Asunto/métodos , Asma/terapia , Nebulizadores y Vaporizadores , Autocuidado , Antiasmáticos/administración & dosificación , Atención Primaria de Salud/métodosRESUMEN
Introducción: Las infecciones del tracto urinario son, junto con las respiratorias, las que generan más consultas médicas en atención primaria. Como la infección no complicada no requiere cultivo y en la infección complicada hay que tratar antes de tener los resultados microbiológicos, el tratamiento antibiótico, por lo menos al inicio, es empírico.Material y métodos: Se analizan los datos de sensibilidad a antimicrobianos de los patógenos urinariosmás importantes aislados en el Hospital «Arquitecto Marcide» de Ferrol.Resultados: La mayoría de los aislamientos corresponde a enterobacterias. Escherichia coli es el microrganismomás aislado, seguido de Proteus mirabilis y Klebsiella pneumoniae. E. coli presenta una sensibilidad del 93% a amoxicilina-ácido clavulánico, del 93% para cefuroxima, del 95% para cefotaxima, del 80% para norfloxacino y ciprofloxacino, del 96% para nitrofurantoína, del 76% para cotrimoxazol y del 99% para fosfomicina. La resistencia a fluoroquinolonas depende de la edad y es mayor en pacientes mayores de 50 años. De las bacterias grampositivas, Staphylococcus saprophyticus presenta100% de sensibilidad a cotrimoxazol, un 98% a furantoína y un 96% a ciprofloxacino. Todos los aislados deEnterococcus faecalis y Streptococcus agalactiae son sensibles a penicilina.Conclusiones: E. coli es el principal agente etiológico. Presenta una sensibilidad muy buena para amoxicilina-ácido clavulánico y cefalosporinas de segunda y tercera generación, nitrofurantoína y fosfomicina.La sensibilidad a fluoroquinolonas, aunque fue menor, dadas las características de los propios antibióticos,permite recomendarlas también como primera elección
Introduction: Urinary tract infections, together with respiratory tract infections, are the motive for moremedical consultations in the primary care setting than any other complaints. As a culture is not necessaryin the case of uncomplicated infections and, in complicated infections, treatment must be started before the microbiological results are received, antibiotic therapy, at least initially, is empirical.Material and methods: The data concerning the susceptibility to antibiotics of the urinary pathogens most frequently isolated at Hospital Arquitecto Marcide in Ferrol, a city in northern Spain.Results: The majority of the pathogens were enterobacteria. Escherichia coli is the microorganism most frequently isolated, followed by Proteus mirabilis and Klebsiella pneumoniae. E. coli had a susceptibility of 93% to amoxicillin-clavulanic acid, of 93% to cefuroxime, of 95% to cefotaxime, of 80% to norfloxacin and ciprofloxacin, of 96% to nitrofurantoin, of 76% to cotrimoxazole and of 99% to fosfomycin. The resistance to fluoroquinolones was age-dependent, being greater in patients over 50 years of age. Among the gram-positive bacteria, Staphylococcus saprophyticus had a susceptibility of 100% to cotrimoxazole, of 98% to nitrofurantoin and of 96% to ciprofloxacin. All the Enterococcus faecalis and Streptococcus agalactiae isolates were susceptible penicillin.Conclusions: E. coli is the major etiological agent. It is highly susceptible to amoxicillin-clavulanic acid andto second- and third-generation cephalosporins, nitrofurantoin and fosfomycin. Although susceptibility tofluoroquinolones is less marked, given the characteristics of these antibiotics, they can also be recommended as drugs of first choice in the treatment of these infections (AU)
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Humanos , Infecciones Urinarias/tratamiento farmacológico , Antibacterianos/uso terapéutico , Pruebas de Sensibilidad Microbiana , Cistitis/tratamiento farmacológico , Atención Primaria de Salud/métodos , Escherichia coli/patogenicidad , Infecciones por Escherichia coli/tratamiento farmacológico , Infecciones por Escherichia coli/epidemiologíaRESUMEN
This case report describes a patient with an automatic ICD who suffered a defibrillation shock without warning symptoms. An electrical interference can be observed in the stored EGM of the episode. The patient explained that the moment he felt the shock he was touching a washing machine. After correct grounding of this machine the patient did not suffer more inappropriate shocks.
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Desfibriladores Implantables/efectos adversos , Electricidad/efectos adversos , Fibrilación Ventricular/terapia , Falla de Equipo , Artículos Domésticos/instrumentación , Humanos , Masculino , Persona de Mediana EdadRESUMEN
The crystal structure of human deoxy hemoglobin (Hb) complexed with a potent allosteric effector (2-[4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylpropionic acid) = RSR-13) is reported at 1.85 A resolution. Analysis of the hemoglobin:effector complex indicates that two of these molecules bind to the central water cavity of deoxy Hb in a symmetrical fashion, and that each constrains the protein by engaging in hydrogen bonding and hydrophobic interactions with three of its four subunits. Interestingly, we also find that water-mediated interactions between the bound effectors and the protein make significant contributions to the overall binding. Physiologically, the interaction of RSR-13 with Hb results in increased oxygen delivery to peripheral tissues. Thus, this compound has potential therapeutic application in the treatment of hypoxia, ischemia, and trauma-related blood loss. Currently, RSR-13 is in phase III clinical trials as a radiosensitizing agent in the treatment of brain tumors. A detailed structural analysis of this compound complexed with deoxy Hb has important implications for the rational design of future analogs.
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Compuestos de Anilina/química , Compuestos de Anilina/farmacología , Hemoglobinas/antagonistas & inhibidores , Hemoglobinas/química , Propionatos/química , Propionatos/farmacología , Regulación Alostérica/efectos de los fármacos , Sitio Alostérico/efectos de los fármacos , Compuestos de Anilina/metabolismo , Compuestos de Anilina/uso terapéutico , Antidrepanocíticos/química , Antidrepanocíticos/metabolismo , Antidrepanocíticos/farmacología , Antidrepanocíticos/uso terapéutico , Ensayos Clínicos Fase III como Asunto , Cristalografía por Rayos X , Diseño de Fármacos , Hemoglobinas/aislamiento & purificación , Hemoglobinas/metabolismo , Humanos , Enlace de Hidrógeno , Modelos Moleculares , Propionatos/metabolismo , Propionatos/uso terapéutico , Conformación Proteica/efectos de los fármacos , Relación Estructura-Actividad , Agua/química , Agua/metabolismoRESUMEN
BACKGROUND: Some patients with acute myocardial infarction presenting without significant ST segment elevation develop a Q-wave infarction. It is unclear whether these patients can be identified from the admission electrocardiogram (ECG) and whether they differ in their in-hospital prognosis from those who retain a non-Q-wave myocardial infarction. METHODS: In 432 consecutive patients admitted to our centre with a first acute myocardial infarction without Q waves and with ST segment amplitudes < or =0.1 mV on admission, we assessed the frequency, the electrocardiographic predictors and the short-term implications of a Q-wave evolution. RESULTS: In 94 patients (22%), a Q-wave myocardial infarction evolved before hospital discharge (14 anterior, 26 inferior, six lateral, and 48 posterior). Minor anterior ST segment elevation was 36% sensitive and 95% specific in predicting anterior Q waves; minor inferior ST segment elevation, 42% and 89%, respectively, for inferior Q waves; and a maximal ST segment depression > or =0.2 mV in leads V2-V3 with upright T waves and without remote ST segment depression, 38% and 97%, respectively, for posterior R waves. Although patients with a Q-wave evolution had a greater creatinkinase MB peak than those retaining a non-Q-wave pattern (191+/-113 vs. 105+/-77 IU/l, respectively, P<0.001), they experienced a benign in-hospital course, with similar risk of severe complications after adjustment for the baseline clinical predictors than non-Q-wave patients. CONCLUSIONS: About one fifth of patients with a first acute myocardial infarction without a significant ST segment elevation develop a Q-wave infarction and the admission ECG can help identify them. This evolution, however, is not associated with a worse in-hospital outcome.
Asunto(s)
Electrocardiografía , Infarto del Miocardio/fisiopatología , Biomarcadores/sangre , Creatina Quinasa/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Infarto del Miocardio/enzimología , Infarto del Miocardio/mortalidad , Pepsinógeno C , Estudios Retrospectivos , Tasa de SupervivenciaRESUMEN
OBJECTIVES: We sought to investigate the short-term prognostic value of the admission electrocardiogram (ECG) in patients with a first acute myocardial infarction (MI) without ST segment elevation. BACKGROUND: ST segment depression on hospital admission predicts a worse outcome in patients with a first acute MI, but the prognostic information provided by the location of ST segment depression remains unclear. METHODS: In 432 patients with a first acute MI without Q waves or > or = 0.1 mV of ST segment elevation, we evaluated the ability of the initial ECG to predict in-hospital death. RESULTS: The presence, magnitude and extent of ST segment depression were associated with an increased mortality, but the only electrocardiographic variable that was significant in predicting death after adjusting for baseline predictors was ST segment depression in two or more lateral (I, aVL, V5, or V6) leads (odds ratio 3.5, 95% confidence interval 1.2 to 10.6). Patients with lateral ST segment depression (n = 91, 21%) had higher rates of death (14.3% vs. 2.6%, p < 0.001), severe heart failure (14.3% vs. 4.1%, p < 0.001) and angina with electrocardiographic changes (20.0% vs. 11.6%, p = 0.04) than did the remaining patients, even though they had similar peak creatine kinase, MB fraction levels (129 +/- 96 vs. 122 +/- 92 IU/liter, p = NS). In contrast, ST segment depression not involving the lateral leads did not predict a poor outcome. Among patients who were catheterized, those with lateral ST segment depression had a lower left ventricular ejection fraction (57 +/- 12% vs. 66 +/- 13%, p = 0.001) and more frequent left main coronary artery or three-vessel disease than did the remaining patients (60% vs. 22%, p < 0.001). CONCLUSIONS: In patients with a first non-ST segment elevation acute MI, ST segment depression in the lateral leads on hospital admission predicts a poor in-hospital outcome.
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Electrocardiografía , Infarto del Miocardio/mortalidad , Infarto del Miocardio/fisiopatología , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Admisión del Paciente , Valor Predictivo de las Pruebas , PronósticoRESUMEN
OBJECTIVES: To assess whether intracoronary catheter balloon inflation triggers a neurally mediated hemodynamic response that interacts with the ischemia-induced myocardial dysfunction. METHODS: Forty-eight chloralose anesthetized pigs underwent a 60 s intraluminal catheter balloon inflation of the proximal left anterior descending (LAD) coronary artery before and after one of these treatments: disruption of LAD pericoronary nerves with phenol (n=6), bilateral stellectomy (n=8), bilateral cervical vagotomy (n=6), atropine (n=5), and ganglionic blockade with hexamethonium (n=10). In 13 other pigs, we assessed the reproducibility of two balloon inflations spaced 15 min (n=6) or 60 min (n=7). The ECG, left ventricular (LV) pressure, and LV dP/dt were recorded during each intervention. Right ventricular (RV) pressure, RV dP/dt, and aortic blood flow were also measured in a subset of pigs. RESULTS: Balloon inflation induced an early (10 s) and reproducible (ANOVA, P<0.001) drop in systolic pressure and peak dP/dt; a decrease in aortic blood flow; a rise in end-diastolic pressure; and elevation of the ST segment. Pericoronary denervation, stellectomy and ganglionic blockade attenuated (P<0.001) the drop in LV parameters during coronary inflation, but atropine and vagotomy did not. CONCLUSIONS: A depressor hemodynamic response subserved by pericoronary nerves worsens the LV dysfunction induced by brief coronary catheter balloon inflation in anesthetized pigs. Cholinergic fibers do not appear to play a major role.
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Angioplastia Coronaria con Balón/efectos adversos , Sistema Nervioso Autónomo/fisiopatología , Enfermedad Coronaria/fisiopatología , Hemodinámica , Análisis de Varianza , Animales , Atropina/farmacología , Enfermedad Coronaria/terapia , Electrocardiografía , Femenino , Ganglios Autónomos/cirugía , Bloqueadores Ganglionares/farmacología , Frecuencia Cardíaca , Hexametonio/farmacología , Masculino , Modelos Biológicos , Antagonistas Muscarínicos/farmacología , Fenol/farmacología , Procesamiento de Señales Asistido por Computador , Porcinos , Vagotomía , Presión VentricularRESUMEN
The concentration of specific progesterone receptor (RP) has been measured in the endometrium of 31 normal menstruating women during the two phases of their menstrual cycle, and compared with the plasma oestradiol-17 beta (E2) concentrations. There was no relationship between RP and plasma E2 when the two phases of the cycle were considered, however a correlation was observed when the follicular phase was only considered. The relationship between oestrogen and RP was then more directly studied in a breast cancer cell line in tissue culture (MCF-7). RP induction by E2 as well as oestriol was demonstrated, but oestrone was ineffective.
PIP: 31 patients were observed to measure the concentration of progesterone receptor (PR) in the endometrium during the 2 phases of the menstrual cycle; concentrations were then compared with those of plasma estradiol-17 beta (E2). A relationship between RP and plasma E2 was found only when the follicular phase of the cycle was considered. When the relationship between estrogen and RP was studied in a breast cancer cell in tissue culture, RP induced by E2 and by estriol was found, but not by estrone.