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1.
Front Psychol ; 15: 1427090, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-39328813

RESUMEN

The global prevalence of autism spectrum disorder (ASD) is increasing. ASD manifests with persistent social communication and interaction challenges, limited interests, and repetitive behaviors. As the scientific literature on ASD in adults varies greatly, mapping the recent global research becomes valuable for enhancing comprehension of this subject. This study aims to map recent global scientific publications on ASD in adults. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, bibliometrics, and network analyses, we assessed 850 articles indexed in the Web of Science Core Collection between 2013 and 2022 assigned to the research area of psychology. Findings indicate an annual average growth of 11.69%. Key keywords include Emotion, Anxiety, and Depression, with Anxiety, Depression, and Mental Health as central nodes in the network. Rehabilitation, Behavioral Sciences, and Psychiatry frequently co-occur, and Psychology, Psychiatry, and 'Neurosciences and Neurology' are central nodes in the network of research areas. The United States of America and the United Kingdom lead in publications, with the United Kingdom being the most central country in the network. King's College London and the University of California are the main research organizations, with King's College London as the central node in the network. The American Psychiatric Association's DSM-5-TR was the most cited reference in the period. This comprehensive analysis contributes to understanding the landscape of ASD research in adults, providing insights for future research and fostering collaborations.

2.
Med Sci Educ ; 34(3): 551-560, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38887406

RESUMEN

Background: Problem-based learning (PBL) constructs a curriculum that merges theory and practice by employing clinical scenarios or real-world problems. Originally designed for the pre-clinical phase of undergraduate medicine, PBL has since been integrated into diverse aspects of medical education. Therefore, this study aims to map the global scientific landscape related to PBL in medical education in the last ten years. Methods: We combined bibliometrics and network analysis to analyze the metadata of related research articles published between 2013 and 2022 and indexed in the Web of Science Core Collection. Results: Our results show an annual publication rate of 9.42%. The two main journals disseminating research on this subject are BMC Medical Education and Medical Teacher. Education & Educational Research and Health Care Sciences & Services are the two most frequent research areas, and also the two most central nodes of the related network. The USA and China are the most publishing countries, while the Netherlands and Canada are the most collaborative. The Maastricht University holds the position of most publishing and collaborative research organization. The University of California ranks second in publications, while the University of Toronto is the second most central research organization. Conclusions: Our study provides an overview of the last ten years of publications related to PBL and medical education, and we hope it can be of interest to educators, researchers, and students involved with this subject. Supplementary Information: The online version contains supplementary material available at 10.1007/s40670-024-02003-1.

3.
Curr Oncol ; 30(3): 3432-3446, 2023 03 16.
Artículo en Inglés | MEDLINE | ID: mdl-36975473

RESUMEN

Cancer significantly contributes to global mortality, with 9.3 million annual deaths. To alleviate this burden, the utilization of artificial intelligence (AI) applications has been proposed in various domains of oncology. However, the potential applications of AI and the barriers to its widespread adoption remain unclear. This study aimed to address this gap by conducting a cross-sectional, global, web-based survey of over 1000 AI and cancer researchers. The results indicated that most respondents believed AI would positively impact cancer grading and classification, follow-up services, and diagnostic accuracy. Despite these benefits, several limitations were identified, including difficulties incorporating AI into clinical practice and the lack of standardization in cancer health data. These limitations pose significant challenges, particularly regarding testing, validation, certification, and auditing AI algorithms and systems. The results of this study provide valuable insights for informed decision-making for stakeholders involved in AI and cancer research and development, including individual researchers and research funding agencies.


Asunto(s)
Inteligencia Artificial , Neoplasias , Humanos , Estudios Transversales , Algoritmos , Oncología Médica , Neoplasias/terapia
4.
Mem Inst Oswaldo Cruz ; 117: e210376, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35703661

RESUMEN

BACKGROUND: The Memórias do Instituto Oswaldo Cruz (MIOC) is one of the first scientific journals created in Brazil and currently one of the most important biomedical journals in South America. Knowledge of the main themes disseminated over time and its main contributors can contribute towards a better understanding of its trajectory and future. OBJECTIVES: Map the journal's scientific publication between 1909 and 2020. METHODS: Data from three scientific databases was combined, alongside bibliometrics and network analysis to analyse publication records between 1909 and 2020. FINDINGS: Publications increased substantially since the 1980s. The main publishing organisations are Brazilian. Excluding Brazil, the main publishing countries are the USA, Argentina, and Colombia. During the entire investigated period, the main themes refer to Chagas disease, schistosomiasis, and Leishmaniasis. During some periods, publications followed disease outbreaks in Brazil (e.g., dengue fever and yellow fever). MAIN CONCLUSIONS: Since its foundation in 1909, the MIOC has focused on infectious and parasitic diseases. The editorial changes implemented from the 1980s onwards led MIOC to a relevant growth concerning annual publications and its transformation into an important communication vehicle for researchers from several Brazilian organisations besides Fiocruz, as well as organisations from other countries, especially within Latin America.


Asunto(s)
Bibliometría , Leishmaniasis , Brasil , Brotes de Enfermedades , Humanos , América Latina
5.
Ther Adv Rare Dis ; 3: 26330040221100840, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-37180410

RESUMEN

Introduction: Rare genetic diseases affect millions of people worldwide. Most of them are caused by defective genes that impair quality of life and can lead to premature death. As genetic therapies aim to fix or replace defective genes, they are considered the most promising treatment for rare genetic diseases. Yet, as these therapies are still under development, it is still unclear whether they will be successful in treating these diseases. This study aims to address this gap by assessing researchers' opinions on the future of genetic therapies for the treatment of rare genetic diseases. Methods: We conducted a global cross-sectional web-based survey of researchers who recently authored peer-reviewed articles related to rare genetic diseases. Results: We assessed the opinions of 1430 researchers with high and good knowledge about genetic therapies for the treatment of rare genetic diseases. Overall, the respondents believed that genetic therapies would be the standard of care for rare genetic diseases before 2036, leading to cures after this period. CRISPR-Cas9 was considered the most likely approach to fixing or replacing defective genes in the next 15 years. The respondents with good knowledge believed that genetic therapies would only have long-lasting effects after 2036, while those with high knowledge were divided on this issue. The respondents with good knowledge on the subject believed that non-viral vectors are more likely to be successful in fixing or replacing defective genes in the next 15 years, while most of the respondents with high knowledge believed viral vectors would be more successful. Conclusion: Overall, the researchers who participated in this study expect that in the future genetic therapies will greatly benefit the treatment of patients with rare genetic diseases.


A global survey of researchers on the future of genetic therapies for rare genetic diseases Rare genetic diseases are caused by defective genes that result from one or more mutations in the genome. Today, the therapeutic options for these diseases are limited, and there are approved treatments for about 5% of them. In the future, genetic therapies (a group of techniques developed to correct defective genes) are expected to revolutionize the treatment of rare genetic diseases. Although promising, most of these therapies are currently under development and have a long way to go before their efficacy and safety can be proved. The uncertainty surrounding this topic therefore means the success of genetic therapies in treating or curing rare genetic diseases is not yet assured. To address this knowledge gap, we surveyed 1430 researchers working in rare genetic diseases about the future of genetic therapies for the treatment of these diseases over the next 15 years. Most of them expected gene therapies to be the standard of care for rare genetic diseases before 2036 and to be able to cure them after this date. CRISPR-Cas9 was felt to be the gene editing approach that was most likely to succeed in fixing or replacing defective genes in the next 15 years. The respondents with high knowledge about gene therapies for the treatment of rare diseases believed gene therapies would have long-lasting effects before 2036, while those with good knowledge expected this to be the case only after 2036. The former believed in viral vectors and the latter in non-viral vectors to fix or replace defective genes in the next 15 years.

6.
Mem. Inst. Oswaldo Cruz ; 117: e210376, 2022. tab, graf
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1386365

RESUMEN

BACKGROUND The Memórias do Instituto Oswaldo Cruz (MIOC) is one of the first scientific journals created in Brazil and currently one of the most important biomedical journals in South America. Knowledge of the main themes disseminated over time and its main contributors can contribute towards a better understanding of its trajectory and future. OBJECTIVES Map the journal's scientific publication between 1909 and 2020. METHODS Data from three scientific databases was combined, alongside bibliometrics and network analysis to analyse publication records between 1909 and 2020. FINDINGS Publications increased substantially since the 1980s. The main publishing organisations are Brazilian. Excluding Brazil, the main publishing countries are the USA, Argentina, and Colombia. During the entire investigated period, the main themes refer to Chagas disease, schistosomiasis, and Leishmaniasis. During some periods, publications followed disease outbreaks in Brazil (e.g., dengue fever and yellow fever). MAIN CONCLUSIONS Since its foundation in 1909, the MIOC has focused on infectious and parasitic diseases. The editorial changes implemented from the 1980s onwards led MIOC to a relevant growth concerning annual publications and its transformation into an important communication vehicle for researchers from several Brazilian organisations besides Fiocruz, as well as organisations from other countries, especially within Latin America.

7.
Artif Organs ; 45(1): 79-87, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32697860

RESUMEN

Patients with kidney failure can only survive with some form of kidney replacement (transplant or dialysis). Unfortunately, innovations in kidney replacement therapy lag behind many other medical fields. This study compiles expert opinions on candidate technologies for future kidney replacement therapies. A worldwide web-based survey was conducted with 1566 responding experts, identified from scientific publications on kidney (renal) replacement therapy, indexed in the Web of Science Core Collection (period 2014-2019). Candidate innovative approaches were categorized in line with the Kidney Health Initiative roadmap for innovative kidney replacement therapies. Most respondents expected a revolution in kidney replacement therapies: 68.59% before 2040 and 24.85% after 2040, while 6.56% expected none. Approaches anticipated as most likely were implantable artificial kidneys (38.6%) and wearable artificial kidneys (32.4%). A majority of experts expect that kidney replacement therapies can be significantly improved by innovative technologies.


Asunto(s)
Diseño de Equipo/tendencias , Fallo Renal Crónico/terapia , Riñones Artificiales/tendencias , Terapia de Reemplazo Renal/tendencias , Humanos , Terapia de Reemplazo Renal/métodos
8.
Hum Gene Ther ; 31(15-16): 852-862, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32718240

RESUMEN

In the next decades, gene editing technologies are expected to be used in the treatment and prevention of human diseases. Yet, the future uses of gene editing in medicine are still unknown, including its applicability and effectiveness to the treatment and prevention of infectious diseases, cancer, and monogenic and polygenic hereditary diseases. This study aims to address this gap by analyzing the views of over 1,000 gene editing-related researchers from all over the world. Some of our survey results show that, in the next 10 years, DNA double-strand breaks are expected to be the main method for gene editing, and CRISPR-Cas systems to be the mainstream programmable nuclease. In the same period, gene editing is expected to have more applicability and effectiveness to treat and prevent infectious diseases and cancer. Off-targeting mutations, reaching therapeutic levels of editing efficiency, difficulties in targeting specific tissues in vivo, and regulatory and ethical challenges are among the most relevant factors that might hamper the use of gene editing in humans. In conclusion, our results suggest that gene editing might become a reality to the treatment and prevention of a variety of human diseases in the coming 10 years. If the future confirms these researchers' expectations, gene editing could change the way medicine, health systems, and public health deal with the treatment and prevention of human diseases.


Asunto(s)
Sistemas CRISPR-Cas , Edición Génica , Enfermedades Genéticas Congénitas/terapia , Terapia Genética , Genoma Humano , Investigadores/estadística & datos numéricos , Enfermedades Genéticas Congénitas/genética , Investigación Genética , Humanos , Investigadores/psicología , Encuestas y Cuestionarios
9.
Mem Inst Oswaldo Cruz ; 115: e190342, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32187325

RESUMEN

BACKGROUND: The five BRICS (Brazil, Russian, Indian, China, and South Africa) countries bear 49% of the world's tuberculosis (TB) burden and they are committed to ending tuberculosis. OBJECTIVES: The aim of this paper is to map the scientific landscape related to TB research in BRICS countries. METHODS: Were combined bibliometrics and social network analysis techniques to map the scientific publications related to TB produced by the BRICS. Was made a descriptive statistical data covering the full period of analysis (1993-2016) and the research networks were made for 2007-2016 (8,366 records). The bubble charts were generated by VantagePoint and the networks by the Gephi 0.9.1 software (Gephi Consortium 2010) from co-occurrence matrices produced in VantagePoint. The Fruchterman-Reingold algorithm provided the networks' layout. FINDINGS: During the period 1993-2016, there were 38,315 peer-reviewed, among them, there were 11,018 (28.7%) articles related by one or more authors in a BRICS: India 38.7%; China 23.8%; South Africa 21.1%; Brazil 13.0%; and Russia 4.5% (The total was greater than 100% because our criterion was all papers with at least one author in a BRICS). Among the BRICS, there was greater interaction between India and South Africa and organisations in India and China had the highest productivity; however, South African organisations had more interaction with countries outside the BRICS. Publications by and about BRICS generally covered all research areas, especially those in India and China covered all research areas, although Brazil and South Africa prioritised infectious diseases, microbiology, and the respiratory system. MAIN CONCLUSIONS: An overview of BRICS scientific publications and interactions highlighted the necessity to develop a BRICS TB research plan to increase efforts and funding to ensure that basic science research successfully translates into products and policies to help end the TB epidemic.


Asunto(s)
Bibliometría , Investigación Biomédica/estadística & datos numéricos , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Sesgo de Publicación , Tuberculosis , Brasil , China , Humanos , India , Federación de Rusia , Sudáfrica
10.
Mem. Inst. Oswaldo Cruz ; 115: e190342, 2020. graf
Artículo en Inglés | LILACS | ID: biblio-1091239

RESUMEN

BACKGROUND The five BRICS (Brazil, Russian, Indian, China, and South Africa) countries bear 49% of the world's tuberculosis (TB) burden and they are committed to ending tuberculosis. OBJECTIVES The aim of this paper is to map the scientific landscape related to TB research in BRICS countries. METHODS Were combined bibliometrics and social network analysis techniques to map the scientific publications related to TB produced by the BRICS. Was made a descriptive statistical data covering the full period of analysis (1993-2016) and the research networks were made for 2007-2016 (8,366 records). The bubble charts were generated by VantagePoint and the networks by the Gephi 0.9.1 software (Gephi Consortium 2010) from co-occurrence matrices produced in VantagePoint. The Fruchterman-Reingold algorithm provided the networks' layout. FINDINGS During the period 1993-2016, there were 38,315 peer-reviewed, among them, there were 11,018 (28.7%) articles related by one or more authors in a BRICS: India 38.7%; China 23.8%; South Africa 21.1%; Brazil 13.0%; and Russia 4.5% (The total was greater than 100% because our criterion was all papers with at least one author in a BRICS). Among the BRICS, there was greater interaction between India and South Africa and organisations in India and China had the highest productivity; however, South African organisations had more interaction with countries outside the BRICS. Publications by and about BRICS generally covered all research areas, especially those in India and China covered all research areas, although Brazil and South Africa prioritised infectious diseases, microbiology, and the respiratory system. MAIN CONCLUSIONS An overview of BRICS scientific publications and interactions highlighted the necessity to develop a BRICS TB research plan to increase efforts and funding to ensure that basic science research successfully translates into products and policies to help end the TB epidemic.


Asunto(s)
Humanos , Publicaciones Periódicas como Asunto/estadística & datos numéricos , Tuberculosis , Bibliometría , Sesgo de Publicación , Investigación Biomédica/estadística & datos numéricos , Sudáfrica , Brasil , China , Federación de Rusia , India
11.
Oncotarget ; 9(55): 30474-30484, 2018 Jul 17.
Artículo en Inglés | MEDLINE | ID: mdl-30093962

RESUMEN

The aim of this paper is to map the scientific landscape related to cancer research worldwide between 2012 and 2017. We use scientific publication data from Web of Science Core Collection and combine bibliometrics and social network analysis techniques to identify the most relevant journals, research areas, countries and research organizations in cancer scientific landscape. The results show: Oncotarget as the journal with most publications; a significant increase in China's publications, reaching United States' publications in 2017; MD Cancer Center, University of California and Harvard University as organizations with most publications; cell biology as the most frequent research area; breast, lung and colorectal cancer as the most frequent keywords; high density of co-authorship between organizations in the West, especially in the US, and low density between organizations in Asian and lower and medium income countries. Our findings can be used to guide a global knowledge platform guiding policy, planning and funding decisions as well as to establish new institutional collaborations.

12.
Mem. Inst. Oswaldo Cruz ; 112(5): 354-363, May 2017. tab, graf
Artículo en Inglés | LILACS | ID: biblio-841792

RESUMEN

BACKGROUND Despite the current global trend of reduction in the morbidity and mortality of neglected diseases, dengue’s incidence has increased and occurrence areas have expanded. Dengue also persists as a scientific and technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics and social network analysis methods can support the mapping of dengue research and development (R&D) activities worldwide. OBJECTIVES The aim of this paper is to map the scientific scenario related to dengue research worldwide. METHODS We use scientific publication data from Web of Science Core Collection - articles indexed in Science Citation Index Expanded (SCI-EXPANDED) - and combine bibliometrics and social network analysis techniques to identify the most relevant journals, scientific references, research areas, countries and research organisations in the dengue scientific landscape. FINDINGS Our results show a significant increase of dengue publications over time; tropical medicine and virology as the most frequent research areas and biochemistry and molecular biology as the most central area in the network; USA and Brazil as the most productive countries; and Mahidol University and Fundação Oswaldo Cruz as the main research organisations and the Centres for Disease Control and Prevention as the most central organisation in the collaboration network. MAIN CONCLUSIONS Our findings can be used to strengthen a global knowledge platform guiding policy, planning and funding decisions as well as to providing directions to researchers and institutions. So that, by offering to the scientific community, policy makers and public health practitioners a mapping of the dengue scientific landscape, this paper has aimed to contribute to upcoming debates, decision-making and planning on dengue R&D and public health strategies worldwide.


Asunto(s)
Humanos , Dengue , Investigación Biomédica/estadística & datos numéricos , Bibliometría , Salud Global
13.
Mem Inst Oswaldo Cruz ; 112(5): 354-363, 2017 May.
Artículo en Inglés | MEDLINE | ID: mdl-28443981

RESUMEN

BACKGROUND: Despite the current global trend of reduction in the morbidity and mortality of neglected diseases, dengue's incidence has increased and occurrence areas have expanded. Dengue also persists as a scientific and technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics and social network analysis methods can support the mapping of dengue research and development (R&D) activities worldwide. OBJECTIVES: The aim of this paper is to map the scientific scenario related to dengue research worldwide. METHODS: We use scientific publication data from Web of Science Core Collection - articles indexed in Science Citation Index Expanded (SCI-EXPANDED) - and combine bibliometrics and social network analysis techniques to identify the most relevant journals, scientific references, research areas, countries and research organisations in the dengue scientific landscape. FINDINGS: Our results show a significant increase of dengue publications over time; tropical medicine and virology as the most frequent research areas and biochemistry and molecular biology as the most central area in the network; USA and Brazil as the most productive countries; and Mahidol University and Fundação Oswaldo Cruz as the main research organisations and the Centres for Disease Control and Prevention as the most central organisation in the collaboration network. MAIN CONCLUSIONS: Our findings can be used to strengthen a global knowledge platform guiding policy, planning and funding decisions as well as to providing directions to researchers and institutions. So that, by offering to the scientific community, policy makers and public health practitioners a mapping of the dengue scientific landscape, this paper has aimed to contribute to upcoming debates, decision-making and planning on dengue R&D and public health strategies worldwide.


Asunto(s)
Bibliometría , Investigación Biomédica/estadística & datos numéricos , Dengue , Salud Global , Humanos
14.
Rev Saude Publica ; 47 Suppl 2: 140-9, 2013 Jun.
Artículo en Portugués | MEDLINE | ID: mdl-24346731

RESUMEN

OBJECTIVE: Policies that promote research in health were established in the last decade, developing the Brazilian scientific production. This development has not been accompanied by an improvement in the legal-institutional framework, thus hindering the development of research projects, including equipment importation activities. The present study aimed to analyze the equipment importation process for the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). METHODS: A case study was performed with data collected from internal ELSA-Brasil documents in five Investigation Centers and their respective supporting foundations. The following importation documents were analyzed: pulse wave velocity, bioimaging and retinography. Additionally, non-structured interviews with researchers and key informers were conducted in the foundations. Data were treated and organized into three stages: administrative-operational, exchange rate, and fiscal. Lengths of duration of these stages were calculated comparatively among centers. RESULTS: The need to standardize equipment in a multicenter study required a joint action of implementing institutions and foundations. Of all pieces of equipment analyzed, the first stage was administrative-operational, with a varying duration (minimum of eight, maximum of 101, and mean of 55 days) which was longer when legal opinions were included. The second stage was the exchange rate, which was longer than the former and did not pose any obstacles to the process (minimum of 11, maximum of 381, and mean of 196 days). The third stage was fiscal, which was the longest one (minimum of 43, maximum of 388, and mean of 215.5 days), due to the release of equipment without registration into the country. There were other factors that posed obstacles: inexperience of investigation centers and institutions in networking; inadequacy of the national legislation on scientific research particularities; and the lack of specialized professionals in scientific project management. CONCLUSIONS: The results show the slowness of the equipment importation process in Brazil, especially due to legal, bureaucratic and managerial obstacles.


Asunto(s)
Investigación Biomédica/instrumentación , Enfermedad Crónica , Comercio/organización & administración , Equipos y Suministros , Internacionalidad , Adulto , Brasil , Humanos , Estudios Longitudinales , Factores de Tiempo
15.
Rev. saúde pública ; Rev. saúde pública;47(supl.2): 140-149, jun. 2013. tab, graf
Artículo en Portugués | LILACS | ID: lil-688075

RESUMEN

OBJETIVO: Políticas de fomento à pesquisa em saúde foram estabelecidas na última década, avançando a produção científica nacional. Tal movimento não foi acompanhado do aperfeiçoamento do arcabouço legal-institucional, dificultando o desenvolvimento dos projetos de pesquisa. Isso inclusive no que tange às atividades de importação de equipamentos. O objetivo deste artigo foi analisar o processo de importação de equipamentos para o Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). MÉTODOS: Trata-se de estudo de caso, com dados coletados em documentos internos do ELSA-Brasil em cinco Centros de Investigação e respectivas fundações de apoio. Foram analisados documentos de importação de: velocidade de onda de pulso, bioimagem e retinografia. Adicionalmente, foram realizadas entrevistas não estruturadas com pesquisadores e informantes chave nas fundações. Os dados foram tratados e organizados em três etapas: administrativa-operacional, cambial e fiscal. Foram calculados os intervalos de duração dessas etapas de modo comparativo entre os centros. RESULTADOS: A necessidade de padronização dos equipamentos em estudo multicêntrico exigiu atuação conjunta de instituições executoras e fundações. Dos equipamentos analisados, a primeira etapa, a administrativa-operacional, teve duração variada (mínimo 8 e máximo de 101, com média de 55 dias), sendo mais demorada quando incluía pareceres jurídicos. A segunda etapa, a cambial, mais longa que a primeira, não apresentou entraves ao processo (mínimo 11 e máximo 381, média de 196 dias). A terceira etapa, a fiscal, foi a mais longa (mínimo 43 e máximo 388 dias, média de 215,5 dias), ...


OBJECTIVE: Policies that promote research in health were established in the last decade, developing the Brazilian scientific production. This development has not been accompanied by an improvement in the legal-institutional framework, thus hindering the development of research projects, including equipment importation activities. The present study aimed to analyze the equipment importation process for the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil). METHODS: A case study was performed with data collected from internal ELSA-Brasil documents in five Investigation Centers and their respective supporting foundations. The following importation documents were analyzed: pulse wave velocity, bioimaging and retinography. Additionally, non-structured interviews with researchers and key informers were conducted in the foundations. Data were treated and organized into three stages: administrative-operational, exchange rate, and fiscal. Lengths of duration of these stages were calculated comparatively among centers. RESULTS: The need to standardize equipment in a multicenter study required a joint action of implementing institutions and foundations. Of all pieces of equipment analyzed, the first stage was administrative-operational, with a varying duration (minimum of eight, maximum of 101, and mean of 55 days) which was longer when legal opinions were included. The second stage was the exchange rate, which was longer than the former and did not pose any obstacles to the process (minimum of 11, maximum of 381, and mean of 196 days). The third stage was fiscal, which was the longest one (minimum of 43, maximum of 388, and mean of 215.5 days), due to the release of equipment without registration into the country. There were other factors that posed obstacles: inexperience of investigation centers and institutions in networking; inadequacy of the national legislation on scientific ...


Asunto(s)
Adulto , Humanos , Investigación Biomédica/instrumentación , Enfermedad Crónica , Comercio/organización & administración , Equipos y Suministros , Internacionalidad , Brasil , Estudios Longitudinales , Factores de Tiempo
16.
Saúde Soc ; 22(1): 85-98, jan.-mar. 2013. tab
Artículo en Portugués | LILACS | ID: lil-674702

RESUMEN

Em caráter exploratório, o objetivo deste artigo é analisar o Programa de Controle da Tuberculose (PCTs) dos Estados da Bahia e Goiás e respectivas capitais, Salvador e Goiânia, a partir da Teoria dos Custos de Transação. Para tanto, foi realizado um estudo de caso nos PCTs citados, utilizando-se, junto aos seus gestores, do método de entrevistas aprofundadas semidiretivas. Os resultados sugerem: (a) baixa especificidade em ativos humanos; (b) baixo grau de incerteza - relacionada à flutuação da demanda e à introdução de novas tecnologias (medicamentos); (c) aspectos relacionados à racionalidade limitada (informação incompleta) são pouco relevantes - no que tange à redação do contrato (Programa Nacional de Controle da Tuberculose - PNCT) e ao Sistema de Informação de Agravos de Notificação (SINAN); (d) e alta probabilidade de ocorrência de comportamento de tipo oportunista (risco moral) - devido ao não monitoramento das ações, à ausência de punições em caso de descumprimento das ações pactuadas no PNCT e ao regime de incentivos vigente.


Asunto(s)
Humanos , Costos de la Atención en Salud , Gastos en Salud , Política de Salud , Política Pública , Tuberculosis , Entrevistas como Asunto , Estudios de Casos y Controles , Motivación
17.
Cad Saude Publica ; 28(3): 527-36, 2012 Mar.
Artículo en Portugués | MEDLINE | ID: mdl-22415185

RESUMEN

Based on an exploratory discussion, the aim of this article is to investigate whether there is evidence of regressive specialization in the foreign trade pattern of the Brazilian pharmaceutical industry since trade liberalization in the 1990s. A descriptive statistical analysis drew on data for foreign trade in pharmaceutical and organic chemical products, available in the Aliceweb system of the Ministry of Development, Industry, and Foreign Trade, covering the periods 1989-1995 and 1996-2008. The results, especially concerning trends in Brazil's trade with developed countries, suggest evidence of regressive specialization.


Asunto(s)
Comercio/economía , Industria Farmacéutica/economía , Cooperación Internacional , Preparaciones Farmacéuticas/economía , Brasil , Industria Farmacéutica/tendencias , Humanos , Internacionalidad , América Latina , Factores de Tiempo
18.
Cad. saúde pública ; Cad. Saúde Pública (Online);28(3): 527-536, mar. 2012. ilus
Artículo en Portugués | LILACS | ID: lil-616966

RESUMEN

Em caráter exploratório, o objetivo deste artigo é investigar se há indícios de especialização regressiva no padrão de comércio exterior da indústria farmacêutica brasileira, a partir da liberalização comercial dos anos 1990. Para tanto, foi realizada uma análise estatística descritiva valendo-se de dados de comércio exterior de produtos farmacêuticos e químicos orgânicos, disponíveis no sistema ALICEweb, do Ministério do Desenvolvimento, Indústria e Comércio Exterior, abrangendo os períodos 1989-1995 e 1996-2008. Os resultados, sobretudo a evolução do padrão de comércio com países desenvolvidos, sugerem indícios de especialização regressiva.


Based on an exploratory discussion, the aim of this article is to investigate whether there is evidence of regressive specialization in the foreign trade pattern of the Brazilian pharmaceutical industry since trade liberalization in the 1990s. A descriptive statistical analysis drew on data for foreign trade in pharmaceutical and organic chemical products, available in the Aliceweb system of the Ministry of Development, Industry, and Foreign Trade, covering the periods 1989-1995 and 1996-2008. The results, especially concerning trends in Brazil's trade with developed countries, suggest evidence of regressive specialization.


Asunto(s)
Humanos , Comercio/economía , Industria Farmacéutica/economía , Cooperación Internacional , Comercialización de Medicamentos , Preparaciones Farmacéuticas/economía , Brasil , Industria Farmacéutica/tendencias , Internacionalidad , América Latina , Factores de Tiempo
19.
Cien Saude Colet ; 15 Suppl 1: 1333-42, 2010 Jun.
Artículo en Portugués | MEDLINE | ID: mdl-20640292

RESUMEN

The aim of this article is to investigate the adoption and use of information and communication technologies within private dialysis clinics in Bahia State. A case study was developed with companies by applying, to clinics' managerial teams, a research questionnaire adapted from RedeSist and from PINTEC. The sample included 20 companies, listed by CNES of the Ministry of Health, and obtained a positive usage rate data of 60%. The collected quantitative information was analyzed by interviewees' answer frequency distribution. Conclusion indicates that the adoption of information and communication technologies by the clinics is not directly related to their access to these technologies but to the under usage of their economical potential.


Asunto(s)
Instituciones de Atención Ambulatoria , Comunicación , Sistemas de Información , Diálisis Renal , Instituciones de Atención Ambulatoria/economía , Instituciones de Atención Ambulatoria/organización & administración , Brasil , Política Pública
20.
Ciênc. Saúde Colet. (Impr.) ; Ciênc. Saúde Colet. (Impr.);15(supl.1): 1333-1342, jun. 2010.
Artículo en Portugués | LILACS | ID: lil-555665

RESUMEN

O objetivo deste artigo é investigar a adoção e utilização de tecnologias de informação e comunicações nas clínicas de diálise da Bahia. Foi realizado um estudo de caso nas firmas, aplicando-se, junto aos gestores das clínicas, um questionário de pesquisa adaptado da RedeSist e da PINTEC. A amostra abrangeu as vinte empresas arroladas no CNES do Ministério da Saúde, tendo sido obtido 60 por cento de aproveitamento. As informações coletadas, de caráter quantitativo, foram analisadas a partir das distribuições de frequências das respostas dos entrevistados. Concluiu-se que o problema da adoção de tecnologias de informação e comunicações não está no acesso das clínicas de diálise às mesmas, mas sim no subaproveitamento do seu potencial econômico.


The aim of this article is to investigate the adoption and use of information and communication technologies within private dialysis clinics in Bahia State. A case study was developed with companies by applying, to clinics' managerial teams, a research questionnaire adapted from RedeSist and from PINTEC. The sample included 20 companies, listed by CNES of the Ministry of Health, and obtained a positive usage rate data of 60 percent. The collected quantitative information was analyzed by interviewees' answer frequency distribution. Conclusion indicates that the adoption of information and communication technologies by the clinics is not directly related to their access to these technologies but to the under usage of their economical potential.


Asunto(s)
Instituciones de Atención Ambulatoria , Comunicación , Sistemas de Información , Diálisis Renal , Instituciones de Atención Ambulatoria/economía , Instituciones de Atención Ambulatoria/organización & administración , Brasil , Política Pública
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