RESUMEN
Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group. The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing γ-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities. Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood.
Asunto(s)
Diabetes Mellitus/sangre , Metalurgia , Exposición Profesional/análisis , Fumar/sangre , Adulto , Contaminantes Atmosféricos/sangre , Contaminantes Atmosféricos/orina , Arsénico/orina , Cadmio/sangre , Diabetes Mellitus/orina , Monitoreo del Ambiente , Glutatión/sangre , Glutatión Peroxidasa/sangre , Glutatión Transferasa/sangre , Humanos , Plomo/sangre , Masculino , Metalotioneína/sangre , Persona de Mediana Edad , Fumar/orina , Superóxido Dismutasa/sangre , Adulto Joven , gamma-Glutamiltransferasa/sangreRESUMEN
INTRODUCTION: The aim of this study was to evaluate the impact of physical activity on alexithymia and coping strategies among people with multiple sclerosis aged over 40. The hypotheses were that physical activity should have a protective effect on alexithymia, and more particularly, on "emotional identification" and could influence coping strategies because it can be considered as a distractive coping strategy. METHODS: Thirty-seven patients aged 40 years or older were asked to complete a form including an identification sheet and standardized questionnaires: the Bermond-Vorst Alexithymia Questionnaire (version B), the Coping with Health Injuries and Problem Questionnaire, the Fatigue Impact Scale, and the Hospital Anxiety and Depression Scale. RESULTS: The participants with a high or moderate level of physical activity used "information research" as a coping strategy better than those who had a lower level of physical activity. They also analyzed their emotions better. The results revealed an association between these variables and anxiety, depression and fatigue. DISCUSSION: This study provides insight for future research about the impact of physical activity on multiple sclerosis.
Asunto(s)
Adaptación Psicológica/fisiología , Síntomas Afectivos/complicaciones , Actividad Motora , Esclerosis Múltiple/complicaciones , Esclerosis Múltiple/epidemiología , Adulto , Terapias Complementarias/estadística & datos numéricos , Trastorno Depresivo/epidemiología , Trastorno Depresivo/etiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/psicología , Esclerosis Múltiple/terapia , Proyectos Piloto , Encuestas y CuestionariosRESUMEN
The clinical and histochemical examination of hormone-producing serous cystadenomas of the pancreas are presented. The study material was obtained from five female patients. The patients underwent diagnostic examinations, including ultrasonography, computer tomography (CT), magnetic resonance imaging (MRI) and Doppler ultrasonography examination of abdomen. In all cases the presence of serous cystadenoma of pancreas was detected in the histopathologically verified sections. The test applied to immunohistochemically localize paraffin-embedded sections of neoplastic tissues of the pancreas was the LSAB2-HRP test using monoclonal antibodies against epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), synaptophysin, p53 and polyclonal antibodies against insulin, glucagon, somatostatin and pancreatic polypeptide. In one patient, ultrasonography revealed an irregular space filled with fluid resembling a multicellular cystic lesion. The Doppler ultrasonography examination showed a pathologically vascularized focus in the pancreatic head. In the adenoma sections of this patient, the immunohistochemical techniques revealed a strong positive somatostatin, pancreatic polypeptide and synaptophysin expression in the lining epithelium of neoplastic cysts.