RESUMEN
The purpose of the study was the comparative evaluation of antiepileptic drugs (AED) impact on quality of life (QOL). One hundred and ninety-two patients with symptomatic and probably symptomatic focal epilepsies (mean age 30, 6 +/- 1.05) were investigated. All patients received the following AED as monotherapy: valproate (52), carbamazepine (36), topiramate (56), levitiracetam (24), oxcarbazepine (24). The clinical and neurological examination, EEG and/or video-EEG-monitoring, CT and/ or MRA scan, neuropsychological tests (31-item Quality of Life in Epilepsy--QOLIE-31, version 1 and HUDS) were performed after 3 months of treatment. The higher results of QOL assessment were obtained in the LEV and OXC groups (83.3 and 72%, respectively), the lowest ones--in the CBZ and VPA groups (16.5 and 17%). Clinically relevant emotional disorders occurred more frequently in patients receiving TPM (21.8%), VPA (21.4%) and CBZ (16.6%), significantly rarely in the OXC (8.3%) group and were absent in the LEV group. The strong correlations between QOL, effectiveness, adverse effects and psycho-emotional disorders of AED treatment were found. The best QOL scores were observed in patients treated with newer AED.
Asunto(s)
Anticonvulsivantes/administración & dosificación , Epilepsia/psicología , Calidad de Vida , Adolescente , Adulto , Anciano , Relación Dosis-Respuesta a Droga , Electroencefalografía , Epilepsia/tratamiento farmacológico , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento , Adulto JovenRESUMEN
The effect of graphite addition on the mechanism of hydrogen uptake by titanium during mechanochemical activation in hydrogen flow was studied using kinetic, structural, microscopic, and spectroscopic techniques. As was found, already a small graphite admixture of about 0.5 wt % changed the kinetics of mechanically induced H2 sorption and significantly stimulated Ti-H2 interaction. Two new types of occupation sites available for hydrogen were observed, which are characterized by low H2 desorption temperatures: about 650 and 750 K instead of 1000 K.
RESUMEN
The effect of graphite admixture on hydrogen sorption-desorption properties of mechanically activated electron microscopy, temperature-programmed reaction, and temperature-programmed desorption techniques. The major effect of graphite addition was found to be the formation of microporous carbon matrix particles containing randomly distributed titanium particles only several nanometers in diameter. This powder architecture enhances hydrogen transport to the titanium surface without hindrances and promotes titanium-hydrogen interaction by modifying the titanium surface and subsurface layers with interstitial carbon atoms.
RESUMEN
The procedure for the preparation of the necessary volumes of acid and base solutions in certain concentrations is described in brief, as is the determination of mass concentrations of the original acids and bases with the use of quantitative titrometric analysis. Mathematical formulae necessary for this work are presented.