RESUMEN
AIM: To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders. MATERIAL AND METHODS: The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used. Serotonin transporter 5-HTTLPR and STin2 and dopamine transporter 3',-VNTR polymorphisms were determined. RESULTS AND CONCLUSION: The S-allele of the 5-HTTLPR polymorphism is associated with the low efficacy of treatment with selective serotonin reuptake inhibitors. Tricyclic antidepressants are more effective in treatment of psychogenic depression. The authors determined clinical factors that can predict response to treatment of psychogenic and endogenous depression. No predictors were found for organic depression.
Asunto(s)
Antidepresivos Tricíclicos/uso terapéutico , Trastorno Depresivo/tratamiento farmacológico , Trastorno Depresivo/genética , Inhibidores Selectivos de la Recaptación de Serotonina/uso terapéutico , Adulto , Alelos , Trastorno Depresivo Mayor/tratamiento farmacológico , Trastorno Depresivo Mayor/genética , Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/genética , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polimorfismo Genético , Escalas de Valoración Psiquiátrica , Psicometría , Proteínas de Transporte de Serotonina en la Membrana Plasmática/genética , Resultado del TratamientoRESUMEN
Authors studied 160 patients with chronic hepatitis C on antiviral treatment. Depressive disorders developed in 85 patients. Clinical and pharmacotherapeutic features of depression were specified. Predictors for the prevalence, structure and severity of the depressive syndrome were found. The clinical and demographic heterogeneity of depressions was identified. The results of the clinical and statistical analysis allow to specify the nosological qualification of these depressions, to optimize diagnostic and treatment algorithms and to make more effective treatment of the main disease (chronic hepatitis C).