RESUMEN
This paper presents results of the radiological study and DTPA therapy for a worker exposed to a plutonium nitrate solution. Plutonium levels were measured in excreta, blood, plasma and wound for several weeks. Plutonium renal clearance ranged from 110-190 ml min(-1) to 3-4 ml min(-1) at different stages of chelation therapy. Plutonium absorption into blood from the injured skin amounted to 4.3%. As a result of intensive therapy, 96% of absorbed plutonium was successfully excreted.
Asunto(s)
Quemaduras Químicas/tratamiento farmacológico , Terapia por Quelación/métodos , Descontaminación/métodos , Nitratos/toxicidad , Ácido Pentético/administración & dosificación , Plutonio/toxicidad , Traumatismos por Radiación/tratamiento farmacológico , Protección Radiológica/métodos , Administración Tópica , Quemaduras Químicas/complicaciones , Quelantes/administración & dosificación , Humanos , Inyecciones Intravenosas , Masculino , Nitratos/sangre , Nitratos/farmacocinética , Nitratos/orina , Exposición Profesional/análisis , Exposición Profesional/prevención & control , Plutonio/sangre , Plutonio/farmacocinética , Plutonio/orina , Traumatismos por Radiación/etiología , Liberación de Radiactividad Peligrosa , Piel/efectos de los fármacos , Piel/lesiones , Piel/efectos de la radiación , Resultado del Tratamiento , Recuento Corporal Total/métodosAsunto(s)
Biomarcadores de Tumor/sangre , Fibronectinas/sangre , Neoplasias/sangre , Diagnóstico Diferencial , Coagulación Intravascular Diseminada/sangre , Coagulación Intravascular Diseminada/diagnóstico , Coagulación Intravascular Diseminada/etiología , Femenino , Humanos , Masculino , Metástasis de la Neoplasia , Neoplasias/complicaciones , Neoplasias/diagnósticoAsunto(s)
Hemorragia Gastrointestinal/etiología , Enfermedad de Hodgkin/complicaciones , Neoplasias Pulmonares/complicaciones , Neoplasias Gástricas/complicaciones , Adulto , Femenino , Gastrectomía , Hemorragia Gastrointestinal/cirugía , Enfermedad de Hodgkin/cirugía , Humanos , Neoplasias Pulmonares/cirugía , Neoplasias Gástricas/cirugíaAsunto(s)
Neoplasias Colorrectales/fisiopatología , Sistema Digestivo/fisiopatología , Neoplasias Colorrectales/complicaciones , Neoplasias Colorrectales/terapia , Terapia Combinada , Digestión , Procedimientos Quirúrgicos del Sistema Digestivo , Motilidad Gastrointestinal , Humanos , Absorción Intestinal , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/fisiopatologíaRESUMEN
The effect of calipsol and thiopental (the most frequent drugs used for basis anesthesia), as well as their combinations with narcotic analgesics fentanyl, morphine, promedole and a neuroleptic droperidol on the level of carcinoembryonic antigen (CEA) in patients with colonic cancer has been studied. A significant effect of anesthetics on CEA level in the postoperative period has been established. The lowest CEA level was observed when calipsol, morphine, and promedole were used as components of narcotic analgesics.
Asunto(s)
Analgésicos Opioides , Anestesia General , Antígeno Carcinoembrionario/sangre , Neoplasias del Colon/cirugía , Tiopental , Neoplasias del Colon/genética , Humanos , Persona de Mediana EdadRESUMEN
By means of a radioimmunologic method, the serum level of carbohydrate antigen (CA) 19-9 was measured in 96 patients, including 17 with pancreatic cancer, 35--with inflammatory diseases of the pancreas, 44--with cancer of another location. CA 19-9 level in patients with pancreatic cancer was considerably higher than in patients with other diseases and controls.
Asunto(s)
Biomarcadores de Tumor/sangre , Antígeno CA-19-9/sangre , Neoplasias Pancreáticas/diagnóstico , Humanos , Pancreatitis/diagnóstico , Radioinmunoensayo , Juego de Reactivos para Diagnóstico , Valores de Referencia , Sensibilidad y EspecificidadRESUMEN
Blood levels of carcinoembryonic antigen (CEA), alpha-fetoprotein, ferritin, ACTH. triiodothyronine and thyroxin were measured by radioimmunoassay in 217 cases of lung, hepatopancreatoduodenal and colonic cancer, 61 patients with nontumor pathology of those sites and in 37 healthy controls. CEA proved the most reliable marker of lung and colonic cancer and tumor-related mechanical jaundice, its lowest concentration in 65-100% of cancer patients exceeding the highest levels observed in controls. In the colorectal group, CEA level returned to normal after radical surgery and rose again at recurrence or distant metastases. Ferritin, cortisol and ACTH appeared less efficient.
Asunto(s)
Biomarcadores de Tumor/sangre , Adenocarcinoma/diagnóstico , Adulto , Anciano , Carcinoma de Células Pequeñas/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Neoplasias del Sistema Digestivo/diagnóstico , Femenino , Humanos , Neoplasias Pulmonares/diagnóstico , Masculino , Persona de Mediana Edad , Pronóstico , Tuberculosis Pulmonar/diagnósticoAsunto(s)
Enfermedades del Ciego/complicaciones , Enfermedades del Íleon/complicaciones , Obstrucción Intestinal/complicaciones , Quistes Ováricos/complicaciones , Enfermedades del Ciego/cirugía , Femenino , Humanos , Enfermedades del Íleon/cirugía , Obstrucción Intestinal/cirugía , Persona de Mediana Edad , Quistes Ováricos/cirugía , Anomalía TorsionalRESUMEN
Fifty-four patients with viral hepatitis B (VHB) were examined at the height of the disease as were 30 patients with mechanical jaundice (MJ) of tumorous etiology and 19 normal persons. Mechanical jaundice was mainly characterized by a considerable growth of the concentration of carcinoembryonic antigen, whereas VHB by an increase of the cholylglycine level. Concomitant detection of those markers can be used in differential diagnosis of parenchymatous jaundice and mechanical jaundice of tumorous etiology. Alterations of the alpha-fetoprotein level were of no information content.
Asunto(s)
Antígeno Carcinoembrionario/análisis , Colestasis/diagnóstico , Ácido Glicocólico/sangre , Hepatitis B/diagnóstico , alfa-Fetoproteínas/análisis , Adolescente , Adulto , Anciano , Biomarcadores/sangre , Colestasis/sangre , Diagnóstico Diferencial , Hepatitis B/sangre , Humanos , Persona de Mediana EdadRESUMEN
A study of the blood levels of gonadotropic and steroid hormones in 321 breast cancer patients has shown that the basal levels of gonadotropin concentration in them exceed the control values (p less than 0.05); those of the follicle-stimulating hormone--in 54.1% of patients at reproductive age and in menopause less than 5 years and in 33.8% of patients in menopause over 5 years; those of luteotropin--in 50 and 93.5% of patients, respectively. Low basal levels of estradiol and progesterone were found more than 70% of breast cancer patients. A significant decrease in the level of the above hormones (p less than 0.05) was noted after polychemotherapy. An increase in the levels of corticotropin (in 54.5-65.2% of patients) and cortisol (in 81.6-84.3% of patients) was noted with progression of breast cancer. Data on the above hormones can be used as a diagnostic and prognostic test.
Asunto(s)
Hormona Adrenocorticotrópica/sangre , Neoplasias de la Mama/sangre , Gonadotropinas Hipofisarias/sangre , Progesterona/sangre , Adulto , Femenino , Hormona Folículo Estimulante/sangre , Humanos , Hormona Luteinizante/sangre , Persona de Mediana Edad , Pronóstico , RadioinmunoensayoRESUMEN
Of the 120 patients with colorectal cancer, 24 had distant metastases of a tumor. In these patients, increase in the level of carcinoembryonic antigen (CEA) and ferritin in the peripheral blood serum was noted as compared with those in patients without tumor metastases (P less than 0.001). Measuring of CEA content in the peripheral and regional blood can be used in preoperative diagnosis of metastases of colorectal cancer.
Asunto(s)
Antígeno Carcinoembrionario/análisis , Neoplasias Colorrectales/diagnóstico , Metástasis de la Neoplasia/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Ferritinas/sangre , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , alfa-Fetoproteínas/análisisAsunto(s)
Antígeno Carcinoembrionario/análisis , Neoplasias del Colon/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Neoplasias del Ciego/diagnóstico , Neoplasias del Ciego/cirugía , Neoplasias del Colon/cirugía , Femenino , Humanos , Masculino , Persona de Mediana Edad , Metástasis de la Neoplasia , Pronóstico , Neoplasias del Colon Sigmoide/diagnóstico , Neoplasias del Colon Sigmoide/cirugíaRESUMEN
Large field fractionated irradiation was provided to 32 patients aged 24 to 75 with tumor dissemination in the absence of the effect of other types of therapy including local gamma-beam therapy. The upper part of the body (as a result of the lung involvement) was irradiated in most of the patients. A single dose of irradiation was 100-500 cGy, the total dose--10-24 Gy. Irradiation was delivered from 2 opposite fields using a ROKUS-M unit. The effect was noted in 5 patients, improvement of the general status--in 22, remission--in 5 patients, 16 patients died. Their mean survival time starting from large field irradiation was 6.5 mos (1-10 mos).
Asunto(s)
Neoplasias/radioterapia , Adulto , Anciano , Terapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Metástasis de la Neoplasia , Neoplasias/complicaciones , Neoplasias/mortalidad , Dosificación Radioterapéutica , Inducción de Remisión , Irradiación Corporal TotalAsunto(s)
Mastitis/diagnóstico , Tuberculosis/diagnóstico , Adolescente , Adulto , Anciano , Neoplasias de la Mama/diagnóstico , Errores Diagnósticos , Femenino , Enfermedad Fibroquística de la Mama/diagnóstico , Humanos , Mastectomía Radical , Mastitis/cirugía , Persona de Mediana Edad , Tuberculosis/cirugíaRESUMEN
The immunoradiometric assay of the blood serum was performed in 61 patient with cancer and in 57 patients with tuberculosis of the lungs to determine the content of adrenocorticotropic hormone (ACTH), hydrocortisone, triiodothyronine++ (T3), thyroxin (T4), ferritin and carcinoembryonic antigen (CEA). In 200 patients (104 suffered from pulmonary tuberculosis, 9--pulmonary cancer), entropy of the protein fractions of the blood serum was determined. It was established that in differential diagnosis of pulmonary cancer and tuberculosis, the determination of CEA, hydrocortisone and entropy of the protein fractions of the blood serum in the complex with the other methods were of significant importance, the determination of ACTH and ferritin content were less important.