RESUMEN

UNLABELLED: Forty-eight children with sepsis were studied. Interleukin-13 (IL-13) levels were lower in patients who died at admission (p=0.014) and at 6 h (p=0.037), and in patients with refractory shock at 0 (p=0.03) and particularly at 6 h (p=0.0009). IL-13 levels did not correlate with other cytokines (IL-1b, IL-10, IL-12, TNFr), CRP or neutrophil count. Low IL-13 levels in the early hours of sepsis are associated with poor prognosis. CONCLUSION: IL-13, a Th-2 cytokine fundamental in the pathogenesis of atopy, might also have a protective role against severe infections in children.

Asunto(s)

Interleucina-13/fisiología , Sepsis/fisiopatología , Adolescente , Proteína C-Reactiva/análisis , Niño , Preescolar , Citocinas/sangre , Femenino , Humanos , Inmunoglobulina E/sangre , Recién Nacido , Interleucina-13/sangre , Masculino , Sepsis/sangre , Choque Séptico/sangre