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Fibromyalgia (FM) and climacteric conditions share common epidemiological and clinical features, with FM symptoms often beginning during menopause. Musculoskeletal pain, arthralgia, myalgia and other symptoms are frequently seen in both conditions. Some research suggests a link between the cessation of sex hormones and FM symptoms. Women with FM tend to experience more severe symptoms after menopause, and the severity of FM symptoms can worsen in women who have had a hysterectomy with or without oophorectomy. Despite these similarities, it is essential to treat FM and climacteric conditions separately and follow established guidelines for management. However, it is also important to recognize that both conditions can coexist in the same patient. It is crucial to note that there is limited evidence supporting the effectiveness of menopausal hormone therapy for primary FM management. Therefore, menopausal hormone therapy should not be recommended for FM unless the patient also has climacteric syndrome.

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BACKGROUND: Systemic lupus erythematosus (SLE) is characterised by increased cardiovascular morbidity and mortality risk. We aimed to examine the prevalence of traditional cardiovascular risk factors and their control in an international survey of patients with systemic lupus erythematosus. METHODS: In this multicentre, cross-sectional study, cardiovascular risk factor data from medical files of adult patients (aged ≥18) with SLE followed between Jan 1, 2015, and Jan 1, 2020, were collected from 24 countries, across five continents. We assessed the prevalence and target attainment of cardiovascular risk factors and examined potential differences by country income level and antiphospholipid syndrome coexistence. We used the Systemic Coronary Risk Evaluation algorithm for cardiovascular risk estimation, and the European Society of Cardiology guidelines for assessing cardiovascular risk factor target attainment. People with lived experience were not involved in the research or writing process. FINDINGS: 3401 patients with SLE were included in the study. The median age was 43·0 years (IQR 33-54), 3047 (89·7%) of 3396 patients were women, 349 (10.3%) were men, and 1629 (48·1%) of 3390 were White. 556 (20·7%) of 2681 patients had concomitant antiphospholipid syndrome. We found a high cardiovascular risk factor prevalence (hypertension 1210 [35·6%] of 3398 patients, obesity 751 [23·7%] of 3169 patients, and hyperlipidaemia 650 [19·8%] of 3279 patients), and suboptimal control of modifiable cardiovascular risk factors (blood pressure [target of <130/80 mm Hg], BMI, and lipids) in the entire SLE group. Higher prevalence of cardiovascular risk factors but a better blood pressure (target of <130/80 mm Hg; 54·9% [1170 of 2132 patients] vs 46·8% [519 of 1109 patients]; p<0·0001), and lipid control (75·0% [895 of 1194 patients] vs 51·4% [386 of 751 patients], p<0·0001 for high-density lipoprotein [HDL]; 66·4% [769 of 1158 patients] vs 60·8% [453 of 745 patients], p=0·013 for non-HDL; 80·9% [1017 of 1257 patients] vs 61·4% [486 of 792 patients], p<0·0001 for triglycerides]) was observed in patients from high-income versus those from middle-income countries. Patients with SLE with antiphospholipid syndrome had a higher prevalence of modifiable cardiovascular risk factors, and significantly lower attainment of BMI and lipid targets (for low-density lipoprotein and non-HDL) than patients with SLE without antiphospholipid syndrome. INTERPRETATION: High prevalence and inadequate cardiovascular risk factor control were observed in a large multicentre and multiethnic SLE cohort, especially among patients from middle-income compared with high-income countries and among those with coexistent antiphospholipid syndrome. Increased awareness of cardiovascular disease risk in SLE, especially in the above subgroups, is urgently warranted. FUNDING: None.

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Introduction: After more than 20 years of sustained work, the Latin American Group for the Study of Lupus (GLADEL) has made a significant number of contributions to the field of lupus, not only in the differential role that race/ethnicity plays in its course and outcome but also in several other studies including the beneficial effects of using antimalarials in lupus patients and the development of consensus guidelines for the treatment of lupus in our region. Methods: A new generation of "Lupus Investigators" in more than 40 centers throughout Latin America has been constituted in order to continue the legacy of the investigators of the original cohort and to launch a novel study of serum and urinary biomarkers in patients with systemic lupus erythematosus. Results: So far, we have recruited 807 patients and 631 controls from 42 Latin-American centers including 339 patients with SLE without renal involvement, 202 patients with SLE with prevalent but inactive renal disease, 176 patients with prevalent and active renal disease and 90 patients with incident lupus nephritis. Conclusions: The different methodological aspects of the GLADEL 2.0 cohort are discussed in this manuscript, including the challenges and difficulties of conducting such an ambitious project.

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OBJETIVO: Determinar si existe asociación entre los niveles séricos de vitamina D y el índice de actividad de la enfermedad en pacientes con artritis reumatoide (AR). METODOLOGÍA: Estudio transversal, analítico, retrospectivo realizado en el Hospital Luis Vernaza y el Centro de Reumatología y Rehabilitación. Se incluyó a pacientes entre 18 a 75 años con diagnóstico de AR según los criterios de clasificación 2010 y examen 25-hidroxivitamina D en los últimos 3 meses. La actividad de la enfermedad se evaluó con el 28-joint Desease Activity Score (DAS28) y la proteína C reactiva (PCR) como reactante de fase aguda. Para establecer asociación entre las variables se realizó por el coeficiente de correlación de Spearman. RESULTADOS: Se estudió a un total de 100 pacientes con AR. La media de vitamina D fue de 32,9 ± 11,5ng/ml, el 45% presentó insuficiencia de 25(OH)D y el 55% niveles normales; no se hallaron valores deficientes de vitamina D. De acuerdo con el DAS28-PCR, los pacientes en baja, moderada y alta actividad tuvieron una media de vitamina D de 30,4 ± 10,7, 31,9 ± 10,7 y 31,8 ±12,1 ng/ml, respectivamente. La actividad de la enfermedad y el nivel sérico de vitamina D no se correlacionaron significativamente (p = 0,60). CONCLUSIONES: En nuestro grupo de pacientes con AR no hubo correlación estadísticamente significativa entre los niveles de vitamina D y la actividad de la enfermedad; tampoco se asociaron otras variables determinantes a los niveles de vitamina D

OBJECTIVE: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA). METHODOLOGY: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months. The activity of the disease was assessed with the 28-joint Disease Activity Score (DAS28) and C-reactive protein (CRP) as an acute-phase reactant. Spearman's rank correlation coefficient was used to establish association between the variables. RESULTS: A total of 100 RA patients were studied. The mean vitamin D levels were 32.9 ± 11.5 ng/mL. In all, 45% showed insufficient 25 (OH) D and 55% had normal levels; no deficient vitamin D values were found. According to the DAS28-CRP, patients with low, moderate and high activity had an average vitamin D level of 30.4 ± 10.7, 31.9 ± 10.7, and 31.8 ± 12.1 ng/mL, respectively. There were no significant correlations between the disease activity and the serum vitamin D level (P=.60). CONCLUSION: In our group of RA patients, there was no statistically significant correlation between the levels of vitamin D and the activity of the disease, nor were other determining variables associated with vitamin D levels

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OBJECTIVE: To determine whether there is an association between serum vitamin D levels and the Disease Activity Index in patients with rheumatoid arthritis (RA). METHODOLOGY: An analytical, retrospective, cross-sectional study was performed at the Hospital Luis Vernaza and Center for Rheumatology and Rehabilitation. We included 18 to 75-year-old patients with a diagnosis of RA according to the 2010 classification criteria, and with a 25-hydroxyvitamin D (25 [OH] D) test within the last 3 months. The activity of the disease was assessed with the 28-joint Disease Activity Score (DAS28) and C-reactive protein (CRP) as an acute-phase reactant. Spearman's rank correlation coefficient was used to establish association between the variables. RESULTS: A total of 100 RA patients were studied. The mean vitamin D levels were 32.9 ± 11.5 ng/mL. In all, 45% showed insufficient 25 (OH) D and 55% had normal levels; no deficient vitamin D values were found. According to the DAS28-CRP, patients with low, moderate and high activity had an average vitamin D level of 30.4 ± 10.7, 31.9 ± 10.7, and 31.8 ± 12.1 ng/mL, respectively. There were no significant correlations between the disease activity and the serum vitamin D level (P=.60). CONCLUSION: In our group of RA patients, there was no statistically significant correlation between the levels of vitamin D and the activity of the disease, nor were other determining variables associated with vitamin D levels.

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OBJECTIVE: To describe differential characteristics of axial involvement in ankylosing spondylitis (AS) as compared with that seen in psoriatic arthritis (PsA) and inflammatory bowel disease (IBD) in a cohort of Ibero-American patients. METHODS: This study included 2044 consecutive patients with spondyloarthritis (SpA; ESSG criteria). Demographic, clinical, disease activity, functional ability, quality of life, work status, radiologic, and therapeutic data were evaluated and collected by RESPONDIA members from different Ibero-American countries between June and December 2006. Patients selected for analysis met modified New York criteria (mNY) for AS. RESULTS: A total of 1264 patients met the New York criteria for AS: 1072 had primary AS, 147 had psoriatic, and 45 had IBD-associated spondylitis. Median disease duration was comparable among the 3 patient groups. Patients with primary AS were significantly younger (p = 0.01) and presented a higher frequency of males (p = 0.01) than the other 2 groups. Axial manifestations such as inflammatory back pain and sacroiliac pain were significantly more frequent in patients with primary AS (p = 0.05) versus other groups, whereas frequency of dactylitis, enthesitis, and peripheral arthritis was more common in patients with psoriatic spondylitis (p = 0.05). Spinal mobility was significantly more limited in patients with primary AS versus the other 2 groups (p = 0.0001). Radiologic changes according to BASRI total score were equally significant in primary AS. Disease activity (BASDAI), functional ability (BASFI), and quality of life (ASQoL) scores were comparable in the 3 groups. CONCLUSION: Patients with primary AS had more severe axial involvement than those with spondylitis associated with psoriasis or IBD. Functional capacity, disease activity, and quality of life were comparable among the groups studied.

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Se realizó un muestreo a filocladios de Epiphyllum hookeri en tres hospederos de las plantas en las inmediaciones de la Universidad Simón Rodríguez, Canoabo, estado Carabobo, Venezuela. Las muestras obtenidas en cada hospedero fueron consideradas como muestras independientes y se llevaron a cabo análisis de composición química, de componentes estructurales y de algunos factores antinutricionales. Los filocladios presentaron una humedad de 85,63 ±0,12g/100g de masa fresca y en comparación con otras especies de la familia Cactaceae, se obtuvieron valores (en g/100g materia seca) similares de proteína (7,86 ±0,01), extracto etéreo (2,95 ±0,07), fósforo (0,19 ±0,07) y digestibilidad in vitro de la materia seca (57,14 ±1,28); menores en contenido de cenizas (7,23 ±0,28), calcio (1,13 ±0,06), potasio (0,94 ±0,02), pectina (0,10 ±0,01) y azúcares reductores (0,45 ±0,01), mientras que fueron mayores los contenidos de hierro (37,2 ±0,2mg/100gMS), de energía (434,5 ±0,2kcal/100gMS) y de fibras estructurales. El análisis de factores antinutricionales reveló presencia moderada de saponinas y alcaloides y ausencia de taninos y cianógenos. Los resultados indican que los filocladios de Epiphyllum hookeri pueden ser considerados como fuentes potenciales de suplementos alimentarios en dietas.

Epiphyllum hookeri phyllocladia were sampled from three hosts from plants in the surrounding area of the Simón Rodríguez University, "Los Naranjos" sector, Canoabo, Carabobo state, Venezuela. Samples from each host were considered as independent samples and analyses of chemical composition, structural components and some antinutritional factors were carried out. The phyllocladia showed a humidity value of 85.63 ±0.12 g/100g of fresh mass and in comparison with other species of the Cactaceae family, had similar values (in g/100g of dry matter) of protein (7.86 ±0.01), ether extract (2.95 ±0.07), phosphorus (0.19 ±0.07) and in vitro dry matter digestibility (57.14 ±1.28); a lower content of ashes (7.23 ±0.28), calcium (1.13 ±0.06), potassium (0.94 ±0.02), pectin (0.10 ±0.01) and reducing sugars (0.45 ±0.01), while the contents of iron (37.2 ±0.2mg/100gDM) of energy (434.5 ±0.2kcal/100gDM) and of structural fibers were higher. The analysis of antinutritional factors revealed moderate presence of saponins and alkaloids and absence of tannins and cyanogens. The results indicate that Epiphyllum hookeri phyllocladia can be considered as potential sources of food supplements in diets.

Realizou-se uma amostragem a filocládios de Epiphyllum hookeri em três hospedeiros das plantas nas imediações da Universidade Simón Rodríguez, Canoabo, estado Carabobo, Venezuela. As amostras obtidas em cada hospedeiro foram consideradas como amostras independentes e se realizaram análises de composição química, componentes estruturais e de alguns fatores antinutricionais. Os filocládios apresentaram uma umidade de 85,63 ±0,12g/100g de massa fresca e em comparação com outras espécies da familia Cactaceae, se obtiveram valores (em g/100g matéria seca) similares de proteína (7,86 ±0,01), extrato etéreo (2,95 ±0,07), fósforo (0,19 ±0,07) e digestibilidade in vitro da matéria seca (57,14 ±1,28); menores em conteúdo de cinzas (7,23 ±0,28), cálcio (1,13 ±0,06), potássio (0,94 ±0,02), pectina (0,10 ±0,01) e açúcares redutores (0,45 ±0,01), enquanto que foram maiores os conteúdos de ferro (37,2 ±0,2mg/100gMS), de energia (434,5 ±0,2kcal/100gMS) e de fibras estruturais. A análise de fatores antinutricionais revelou presença moderada de saponinas e alcalóides e ausência de taninos e cianógenos. Os resultados indicam que os filocládios de Epiphyllum hookeri podem ser considerados como fontes potenciais de suplementos alimentares em dietas.

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Se evaluó el efecto del secado solar en los contenidos de humedad, azúcares totales, almidón, carotenoides totales e índice de peróxidos del extracto lipídico del mesocarpio del fruto de la palma coroba. Se empleó el mesocarpio de frutos maduros recolectados en Caicara del Orinoco, Municipio Cedeño, Estado Bolívar, Venezuela. El secado se realizó en un prototipo de secador solar en las siguientes condiciones: temperatura externa 32°C, temperatura en el interior del secador 70°C, humedad relativa 80 por ciento, tiempo de secado 3h, carga 1kg de mesocarpio fresco distribuido en forma de capa de espesor de 2mm. Antes y después del secado se determinó: humedad, azucares totales, almidón, carotenoides totales e índice de peróxidos. Se observaron diferencias significativas (P<0,05) en los valores de carotenoides totales e índice de peróxidos. La evaluación de estos dos parámetros durante el almacenamiento a temperatura ambiente mostró cambios significativos (P<0,05); la degradación de los carotenoides totales siguió una cinética de primer orden (R2= 0,9515) con una constante de velocidad de 0,0208d-1 y tiempo de media reacción de 33,3d. El índice de peróxidos se mantuvo sin cambios significativos (P>0,05) durante 21 días.

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El objetivo del trabajo fue obtener hidrolizados proteícos por vía enzimática a partir de caribe colorado (Pygocentrus cariba Humboldt, 1821) Se seleccionó un lote de 50Kg de especímenes adultos, eviscerados, proveniente del r¡o Igües (Municipio El Baúl, Cojedes, Venezuela). Cada espécimen fue fileteado mediante cortes manuales con cuchillo, el tejido muscular fue separado de la piel, molido con un equipo eléctronico, envasado en bolsas de polietileno y almacenado a -18°C. La hidrólisis fue catalizada por una proteasa comercial grado alimenticio (Alcalase 2.4L). El máximo grado de hidrólisis (GH) alcanzada fue 10,5 por ciento. El rendimiento en hidrolizado proteico deshidratado (HPD) se incrementó con el GH, siendo el máximo valor alcanzado 13,7 g HPD/100 g de músculo molido húmedo. Los hidrolizados presentaron variaciones significativas (p<0,05) en la composición proximal y en las propiedades funcionales. La hidrólisis proteica del pescado caribe colorado con Alcalase es una alternativa recomendable para el aprovechamiento de esta especie que en la actualidad es de poco valor comercial

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Se evaluó la actividad antioxidante de los extractos acuosos y orgánicos provenientes de la cáscara de naranjas. Las cáscaras se procesaron para producir harinas y extraer los flavonoides mediante solventes orgánicos empleando relaciones harina/solvente de 1/2; 1/1,33 y 1/1; los extractos finales fueron secados a presión reducida en un rotaevaporador a 60ºC hasta sequedad. Los productos secos fueron dosificados a muestras de aceite de soja desodorizado en proporciones de 0,01; 0,05 y 0,10%. Las muestras fueron luego colocadas en una estufa de aire a 60 ±1ºC y a intervalos de 24h se les determinó el índice de peróxidos hasta alcanzar un valor máximo de 100meq de O2/kg. El extracto de mayor capacidad antioxidante fue el acuoso en proporción 0,10% (P<0,05).

The antioxidant activity of aqueous and organic flavonoid extracts from orange peels was evaluated. Orange peels were transformed into flour and flavonoids were extracted employing flour/solvent ratios of 1/2, 1/1.33 and 1/1. Final extracts were dried at reduced pressure in a rotaevaporator at 60ºC. Dry products were dosed to deodorized soybean oil in the proportions 0.01, 0.05 and 0.10%. Then, the samples were placed in an air stove at 60 ±1ºC and every 24h peroxide was determined until a maximum value of 100meq O2/kg. The largest antioxidant activity was found with the 0.10% aqueous extract (P<0.05).

Avaliou-se a atividade antioxidante dos extratos aquosos e orgânicos provenientes da casca de laranjas. As cascas se processaram para produzir farinhas e extrair os flavonóides mediante solventes orgânicos empregando relações farinha/solvente de 1/2; 1/1,33 e 1/1; os extratos finais foram secados a pressão reduzida em um rota-evaporador a 60ºC até sequidão. Os produtos secos foram dosificados a amostras de azeite de soja desodorizado em proporções de 0,01; 0,05 e 0,10%. As amostras foram logo colocadas em uma estufa de ar a 60 ±1ºC e a intervalos de 24h, determinou-se nestas o índice de peróxidos até alcançar um valor máximo de 100 meq de O2/kg. O extrato de maior capacidade antioxidante foi o aquoso em proporção 0,10% (P<0,05).

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El objetivo de esta investigación, fue la evaluación microbiológica y de algunos parámetros fisicoquímicos en bebidas pasteurizadas acondicionadas con extractos acuosos de desechos desodorizados de narajanja. Las frutas utilizadas para el estudio se seleccionaron con los siguientes criterios: madurez homogénea, sin daño físico y ausencia aparente de clorofila. Las cáscaras fueron sometidas a un secado parcial y posteriormente procesadas para obtener una harina. El jugo extraído se evaluó mediante los parámetros pH=3,90, °Brix 10, Acidez titulable 0,33 g ácido cítrico/100mL, carotenoides totales de 0,0078 mg/mL. La harina se sometió a dos métodos de desodorización: por arrastre con vapor y en autoclave a temperatura de 121°C. A las cáscaras desodorizadas, se le realizó una extracción de pigmentos usando como solvente agua, con una relación (P/V) 1:50. Posteriormente se prepararon las bebidas cítricas pasteurizadas, sustituyendo el agua de su elaboración por los extractos desodorizados de ambos métodos. Los parámetros analizados: pH, °Brix, Acidez titulable, carotenoides totales, no presentaron diferencias significativas durante las evaluaciones (p>0,05). Los análisis microbiológicos, presentaron valores adecuados para productos pasteurizados. Se realizaron evaluaciones sensoriales mediante la prueba no paramétrica Friedman al 95 por ciento de confianza, utilizando un panel no entrenado, donde no se detectaron diferencias significativas entre los tratamientos. Se concluye que los procesos de desodorización fueron eficientes, permitiendo la incorporación de compuestos aquasolubles como flavonoides que presentan actividad antioxidante en las bebidas fortificadas

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Microbiological and physicochemical parameters of pasteurized beverages conditioned with aqueous extracts from orange deodorized residues were evaluated. The fruits used were selected according to following criterion: homogenous maturity, without physical damage and absence of apparent chlorophyll. Orange peels were dried and transformed to flour. The juice was evaluated by means of these parameters: pH 3.90, degrees Brix 10, titrable acidity 0.33 g of citric acid/100 mL and total carotenoids 0.0078 mg/mL. Volatil compounds of the flour that may to cause bitterness were separated by means of two methods of deodorization: distillation in current of vapor and in autoclave to 121 degrees C; then, the flour was extracted with water (relation 1:50 p/v). Pasteurized citric beverages (orange juice) were elaborated adding the deodorized extracts. pH, degrees Brix, titrable acidity and total carotenoids showed no significant differences (P>0.05). Microbiological results were according to pasteurized products. Sensorial analysis by untrained panel showed no signiificant differences. In conclusion, the deodorant processes were effectives and permitted the inclusion of aquasoluble compounds as flavonoids with antioxidant activity.

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Tree tomato (Cyphomandra betaceae Sendth) is a species from high tropical regions. In Venezuela, it is cultivate at the Andean and Aragua state but its consumption is restricted as fruit-fresh, though it a nutritious and industrial potential due its provitamin A content. In this research four nectars were elaborated in proportion I L pulp/4 L of water (1:4) and addition of ascorbic acid (I: 0%; II: 0.5%; III: 1.0 y IV: 1.5%). The nectars were pasteurized (60 degrees C for 30 min), tuned into amber bottle, and stored under refrigeration conditions (7.0 +/- 1.0 degrees C). Weekly during 21 days the mesophilic bacteria, molds, yeasts, total coliforms (MPN/mL), pH, degree Brix, acidity, total carotenoids, vitamin C and total sugars were evaluated. The mesophilic bacteria content was < 200 UFC/mL for every formulation on the first day the evaluation, molds and yeasts were < 10 UFC/mL and the total coliforms (NPN/mL) < 3 until the third evaluation. No significant differences (P > 0.05) were founded on: pH. degree Brix and total sugars. Significant differences (P < 0.05) were founded in vitamin C and total carotenoids content. Sensorial analysis did not show significant differences between formulations for the smell and flavor attributes, when the color was discriminate during the evaluations. The formulation I (without acid ascorbic) had more preference due its color. In conclusion, the nectars showed useful life of 14-21 days under refrigeration condition storage due to the adequate physicochemical and microbiological quality of the product.

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In this research the chemical stability of total anthocyanins in three pasteurized juices elaborated from 12% of blackberry (Rubus glaucus Benth) pulp, and addition of ascorbic acid (Formulation A: 0.1%, Formulation B: 0.05% and Formulation C: 0.01%), was evaluated by means of absorption visible spectra (400-580 nm). Physicol-chemical characterization (acidity, soluble solids content in degree Brix, pH), and count of mesophilic microorganism, fungi, yeasts, fecal coliforms (PMN/mL) and Escherichia coli, were evaluated. Sensorial parameters (color, smell, flavor) were investigated by means of un-trained panel using a hedonic scale (Fridman, P < 0.05). The study was performed during storage for 9 days. The total anthocyanins were reported as pelargonidin-3-glycoside g/L, and no significant differences were founded among the evaluated in each formulation during storage (P > 0.05). Bactocromic effect due to oxidation as not observed. Acidity (6.0-7.2 mL NaOH 0.079 N), soluble solids content (9.0-9.8 degrees Brix) and pH (3.4) did not show significant differences (P > 0.05). The microbiological evaluation showed minimum values for pasturized products (fungi CFU/mL < 10, yeast CFU/mL < 10, fecal coliforms CFU/mL < 10 and mesophilic microorganism CFU/mL between 120-140 on first day in storage). Sensorial analysis did not show significant differences (Fridman, P > 0.05).

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In this research the chemical stability of total anthocyanins in three pasteurized juices elaborated from 12 of blackberry (Rubus glaucus Benth) pulp, and addition of ascorbic acid (Formulation A: 0.1, Formulation B: 0.05 and Formulation C: 0.01), was evaluated by means of absorption visible spectra (400-580 nm). Physicol-chemical characterization (acidity, soluble solids content in degree Brix, pH), and count of mesophilic microorganism, fungi, yeasts, fecal coliforms (PMN/mL) and Escherichia coli, were evaluated. Sensorial parameters (color, smell, flavor) were investigated by means of un-trained panel using a hedonic scale (Fridman, P < 0.05). The study was performed during storage for 9 days. The total anthocyanins were reported as pelargonidin-3-glycoside g/L, and no significant differences were founded among the evaluated in each formulation during storage (P > 0.05). Bactocromic effect due to oxidation as not observed. Acidity (6.0-7.2 mL NaOH 0.079 N), soluble solids content (9.0-9.8 degrees Brix) and pH (3.4) did not show significant differences (P > 0.05). The microbiological evaluation showed minimum values for pasturized products (fungi CFU/mL < 10, yeast CFU/mL < 10, fecal coliforms CFU/mL < 10 and mesophilic microorganism CFU/mL between 120-140 on first day in storage). Sensorial analysis did not show significant differences (Fridman, P > 0.05).

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