RESUMEN
BACKGROUND: The management of mastodynia plays a central role in improving women quality of life. Despite its high occurrence, specific therapeutic guidelines for mastalgia are still lacking. Available therapies include unspecific anti-inflammatories, even though they may often expose to undesirable effects and low compliance. OBJECTIVE: The aim of this study was to highlight the efficacy of the topical application of combined natural molecules including Boswellia serrata, Betaine and myo-Inositol in improving cyclic mastalgia. METHODS: In this retrospective pilot clinical study, patients with cyclic mastalgia applied a specific breast gel for three months. The severity of the pain was measured through the Visual Analogue Score (VAS) in the treated group compared to untreated one. Treated patients also filled in a questionnaire evaluating acceptance and safety of the breast gel. RESULTS: This pilot clinical study demonstrated for the first time the efficacy of the topical application of a breast gel based on Betaine, Boswellia serrata, and myo-Inositol in improving cyclic mastodynia. The completed questionnaires also revealed high levels of acceptance, as both safety and compliance. CONCLUSIONS: Besides confirming the positive effects of these natural molecules in the management of conditions affecting breast physiology - so far evaluated as oral supplementation - the obtained results pave the way for further studies supporting the use of such molecules as a tailored medical device in the management of breast pain, thus also opening toward a combined oral and topical approach.
Asunto(s)
Betaína , Boswellia , Geles , Inositol , Mastodinia , Humanos , Femenino , Betaína/administración & dosificación , Betaína/uso terapéutico , Estudios Retrospectivos , Adulto , Inositol/uso terapéutico , Inositol/administración & dosificación , Mastodinia/tratamiento farmacológico , Boswellia/química , Proyectos Piloto , Dimensión del Dolor , Encuestas y Cuestionarios , Extractos Vegetales/uso terapéutico , Persona de Mediana EdadRESUMEN
AIMS AND BACKGROUND: Recurrent cervical cancer has traditionally been associated with a dismal prognosis. Historically, patients who developed distant metastases from cervical cancer were not considered eligible for surgical resection; only palliative treatment options are available, generally consisting of chemo- and/or radiotherapy. Metastases usually appear in the liver, lung or lymph nodes. The abdominal cavity is a quite unusual site of recurrence and the disease usually has multiple foci. For this reason, peritoneal involvement by cervical cancer is considered a contraindication to local treatment. METHODS AND STUDY DESIGN: We report the first case of a 30-year-old woman with isolated intra-abdominal cervical cancer recurrence diagnosed with 18F-FDG PET/CT, successfully surgically treated. RESULTS: Histopathological analysis confirmed the tumor to be an omental relapse of squamous cervical cancer previously treated with anterior pelvic exenteration and platinum based chemotherapy. The patient underwent adjuvant treatment with 3 cycles of topotecan and has remained free of disease during the 4 years of follow-up. CONCLUSIONS: In selected cases with isolated recurrences, a surgical resection may provide a long term complete remission in recurrent cervical cancer patients.
Asunto(s)
Carcinoma de Células Escamosas/secundario , Carcinoma de Células Escamosas/cirugía , Recurrencia Local de Neoplasia/cirugía , Epiplón , Neoplasias Peritoneales/secundario , Neoplasias Peritoneales/cirugía , Neoplasias del Cuello Uterino/patología , Adulto , Carcinoma de Células Escamosas/diagnóstico por imagen , Quimioterapia Adyuvante , Medios de Contraste , Femenino , Fluorodesoxiglucosa F18 , Humanos , Recurrencia Local de Neoplasia/diagnóstico por imagen , Epiplón/diagnóstico por imagen , Epiplón/patología , Epiplón/cirugía , Neoplasias Peritoneales/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Tomografía Computarizada por Rayos X , Inhibidores de Topoisomerasa I/uso terapéutico , Topotecan/uso terapéutico , Resultado del TratamientoRESUMEN
PURPOSE: To compare the fertility outcome among women subjected to unilateral ovariectomy and other abdominal or non-gynaecologic pelvic surgery. METHODS: In this retrospective cohort study, 113 fertile women, surgically treated between 1990 and 2001 at Sapienza University of Rome with unilateral ovariectomy (UO), appendectomy (AP) or cholecystectomy (CO) for benign disease, were analysed for fertility outcome. Patients with assessed pre-surgical fertility defects, previous abdominal or pelvic surgeries and post-surgical contraception were not included. RESULTS: Thirty-five women underwent UO, 39 were subjected to AP and 39 were treated with CO. After a minimum 10-year post-surgical interval, the overall number of successful pregnancies was 75. The rate of women who experienced at least one post-operative successful pregnancy was: 48.5 % in UO, 41 % in AP and 53.8 % in CO (UO vs. AP, P = 0.55; UO vs. CO, P = 0.99; AP vs. CO, P = 0.53). One patient (2.8 %) in UO, one patient (2.6 %) in AP and two patients (5.1 %) in CO underwent Assisted Reproductive Technology to become pregnant. The rate of women who reported at least one miscarriage was: 10/35 (28.5 %) in UO, 11/39 (28.2 %) in AP, 12/39 (30.8 %) in CO (UO vs. AP, P = 0.93; UO vs. CO, P = 0.89; AP vs. CO, P = 0.81). One ectopic pregnancy was reported in CO group and one stillbirth occurred in one AP patient. CONCLUSIONS: No statistical difference in terms of post-operative fertility outcome between patients subjected to UO, AP or CO was found, thus allowing to suppose that the removal of one ovary does not significantly worsen the female fertility outcome respect to other abdominal or pelvic procedures.
Asunto(s)
Fertilidad , Ovariectomía/métodos , Aborto Espontáneo/epidemiología , Adulto , Apendicectomía/estadística & datos numéricos , Tasa de Natalidad , Colecistectomía/estadística & datos numéricos , Femenino , Humanos , Italia/epidemiología , Ovariectomía/estadística & datos numéricos , Selección de Paciente , Embarazo , Embarazo Ectópico/epidemiología , Técnicas Reproductivas Asistidas , Estudios Retrospectivos , Mortinato/epidemiología , Resultado del TratamientoRESUMEN
The Bartholin's gland cyst is a condition that occurs in approximately 2% of women, most of whom are of reproductive age. Although benign, it is associated with significant patient discomfort. Definitive treatment involves the surgical removal of the entire cyst. The objective of this study was to describe an alternative conservative surgical technique with CO(2) laser adopted in our institution and to evaluate the feasibility, complication rate, and results obtained with this technique in an office setting. Our study showed that CO(2) laser treatment of the Bartholin's gland cyst can be carried out safely in an outpatient setting, with minimum patient discomfort and high long-term cure rates.
Asunto(s)
Glándulas Vestibulares Mayores/cirugía , Quistes/cirugía , Terapia por Láser , Enfermedades de la Vulva/cirugía , Adolescente , Adulto , Estudios de Factibilidad , Femenino , Humanos , Persona de Mediana Edad , Resultado del TratamientoRESUMEN
Since 2001, Hyalomatrix PA (Fidia Advanced Biopolymers, Abano Terme, Italy) has been used in our center on pediatric burned patients as a temporary dermal substitute to cover deep partial-thickness burns after dermabrasion. This "bridge" treatment was adopted to remove necrotic debris (dermabrasion) and to stimulate regeneration in a humid and protected environment (Hyalomatrix PA). We present results obtained with this approach. On the third to fifth day after admission, dermabrasion was practiced on deep burned areas, which were covered with Hyalomatrix PA. Change of dressings was performed every 7 days. On day 21, those areas still without signs of recovery were removed with classic escharectomy and covered with thin skin grafts. We treated 300 patients. Sixty-one percent needed only one dermabrasion treatment, 22.3% (67 patients) more than one, and 16.7% (50 patients) the classic escharectomy. A total of 83% of patients healed within 21 days. Our study suggests that the combination of dermabrasion with a temporary dermal substitute could be a good and feasible approach for treatment of deep partial-thickness burns. Prospective randomized studies are now necessary to compare our protocol with the gold standard treatment of topical dressings.
Asunto(s)
Quemaduras/terapia , Piel Artificial , Adolescente , Corticoesteroides/uso terapéutico , Antibacterianos/uso terapéutico , Vendajes , Quemaduras/epidemiología , Niño , Preescolar , Cicatriz Hipertrófica/tratamiento farmacológico , Cicatriz Hipertrófica/epidemiología , Dermabrasión , Desinfectantes/uso terapéutico , Femenino , Humanos , Lactante , Inyecciones Intralesiones , Masculino , Trasplante de Piel , Resultado del Tratamiento , Infección de Heridas/epidemiología , Infección de Heridas/terapiaRESUMEN
BACKGROUND: Isolated gastric recurrence due to ovarian cancer is a rare event and is usually associated with gastrointestinal symptoms. CASE REPORT: We report a case of an isolated gastric recurrence of ovarian carcinoma in an otherwise asymptomatic 42-year-old woman in whom diagnosis was made using the FDG-PET/CT scan followed by laparoscopy. CONCLUSIONS: In rare cases, ovarian cancer can directly recur on the stomach without any symptoms. FDG-PET/CT scan and diagnostic laparoscopy are effective in leading to an early diagnosis of disease recurrence.