RESUMEN
OBJECTIVE: To evaluate lipid balance in children after a 5-year follow-up and tracking between initial and final levels. METHODS: Two hundred eighty-one children included in the Rivas-Vaciamadrid study were evaluated at the ages of 6 and 11 years. In all children, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and apoproteins A1 (Apo A) and B100 (Apo B) were measured. Low-density lipoprotein-cholesterol (LDL-C) was determined and the Apo B/Apo A, TC/HDL-C, and LDL-C/HDL-C ratios and the atherogenic index were calculated. RESULTS: At 11 years of age, lipid balance was worse in girls than in boys. Levels of TG and HDL-C were significantly higher at the age of 11 years than those at the age of 6 years, but levels of the remaining variables analyzed were lower, except for Apo A and TC, which showed a non-significant increase. The correlation coefficients between values at the ages of 6 and 11 years were significant for all variables and the highest was LDL-C in girls (0.711). Kappa and Nishio tracking indexes were significant for all variables and were highest for the atherogenic index (0.431 and 6.71 respectively) and lowest for TG (0.129 and 2.85 respectively). Subjects in the highest quartile at 6 years old had a relative risk of 8.04 (CI 4.34-14.88) for having the same atherogenic index at the age of 11 years and a relative risk of 1.91 (CI 1.05-3.46) for having the same TG value. CONCLUSION: There is a significant correlation between lipid profile values in children at the ages of 6 and 11 years. The best tracking was found in the atherogenic index.
Asunto(s)
Lípidos/sangre , Niño , Femenino , Estudios de Seguimiento , Humanos , MasculinoRESUMEN
Objetivo. Evaluar el perfil lipídico en niños tras 5 años de seguimiento, y el tracking entre los valores iniciales y los finales. Métodos. Se estudiaron 281 niños a los 6 y 11 años incluidos en el estudio Rivas-Vaciamadrid. Todos eran prepúberes. A todos se les midió el colesterol total (CT), triglicéridos (TG), colesterol unido a las lipoproteínas de alta densidad (C-HDL), apoproteína A1 (apo-A), y B100 (apo-B100), y se calculó el colesterol unido a las lipoproteínas de baja densidad (C-LDL) y los índices apo-B/apo-A, CT/C-HDL, C-LDL/C-HDL e índice aterogénico. Resultados. A los 11 años el perfil lipídico de las niñas es peor que el de los niños. Se encontraron unos valores a los 11, respecto a los 6 años, significativamente mayores de TG y C-HDL, y menores de los demás parámetros estudiados, excepto de apo-A y el CT que no presentaron significación estadística. Los coeficientes de correlación entre los valores a los 6 y 11 años fueron significativos para todos ellos, encontrándose el más elevado en las niñas para el C-LDL (0,711). Los índices de tracking de k y Nishio fueron significativos para todos los parámetros, oscilando entre los mayores valores obtenidos para el índice aterogénico (0,431 y 6,71, respectivamente) y para los triglicéridos (0,129 y 2,85, respectivamente). El riesgo relativo de un sujeto que estaba en el cuartil superior a los 6 años de estar en el misma situación a los 11 estuvo entre 8,04 (intervalo de confianza [IC]: 4,34-14,88) para el índice aterogénico y 1,91 (IC: 1,05-3,46) para los triglicéridos. Conclusión. Existe una correlación significativa entre los valores del perfil lipídico a los 6 y 11 años, siendo el índice aterogénico el que presenta un mejor tracking
Objective. To evaluate lipid balance in children after a 5-year follow-up and tracking between initial and final levels. Methods. Two hundred eighty-one children included in the Rivas Vaciamadrid study were evaluated at the ages of 6 and 11 years. In all children, total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and apoproteins A1 (Apo A) and B100 (Apo B) were measured. Low-density lipoprotein-cholesterol (LDL-C) was determined and the Apo B/Apo A, TC/HDL-C, and LDL-C/HDL-C ratios and the atherogenic index were calculated. Results. At 11 years of age, lipid balance was worse in girls than in boys. Levels of TG and HDL-C were significantly higher at the age of 11 years than those at the age of 6 years, but levels of the remaining variables analyzed were lower, except for Apo A and TC, which showed a non-significant increase. The correlation coefficients between values at the ages of 6 and 11 years were significant for all variables and the highest was LDL-C in girls (0.711). Kappa and Nishio tracking indexes were significant for all variables and were highest for the atherogenic index (0.431 and 6.71 respectively) and lowest for TG (0.129 and 2.85 respectively). Subjects in the highest quartile at 6 years old had a relative risk of 8.04 (CI 4.34-14.88) for having the same atherogenic index at the age of 11 years and a relative risk of 1.91 (CI 1.05-3.46) for having the same TG value. Conclusion. There is a significant correlation between lipid profile values in children at the ages of 6 and 11 years. The best tracking was found in the atherogenic index
Asunto(s)
Niño , Humanos , Lípidos/sangre , Estudios de SeguimientoRESUMEN
OBJECTIVE: The purpose of this study was to analyze the lipid profiles in children six years of age according to sex and to compare this with other Spanish studies. PATIENTS AND METHODS: A transverse epidemiological study was performed. All six year old children in our area were studied. The following tests were performed in all children: total cholesterol (TC), triglycerides, LDL-C, HDL-C, apoproteins A and B after fasting for ten hours. In addition, TC/HDL-C, LDL-C/HDL-C, and Apo B/A ratios and atherogenic index (ATI) were calculated. RESULTS: A population of 673 subjects (352 males and 321 females) were studied. The value of TC, triglycerides, LDL-C, Apo B, LDL-C/HDL-C and TC/HDL-C were significantly greater in females compared to males. Males had higher levels of HDL-C and ApoA. The values were similar to those obtain in Madrid in 1992, except that the values of HL-C were significantly higher in both sexes. CONCLUSIONS: In six year old children, the lipid profile in girls is worse than in boys. The data from our study do not show that the lipidic risk is getting worse during the past years in Spanish children.