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El objetivo de esta investigación es identificar la relación entre la asimetría facial y la pérdida de contacto en línea mediana entre dientes maxilares y mandibulares. Se realizó un estudio descriptivo en 18 sujetos portadores de asimetría facial que consultaron en la División de Cirugía Oral y Maxilofacial de la Universidad de La Frontera por tratamiento quirúrgico de la asimetría. En todos ellos se evaluó la presencia y grado de la asimetría facial y la presencia y desvío desde la línea mediana facial del punto mediano mandibular y maxilar mediante la prueba estadística t de student considerando un valor de p <0,05; todas las evaluaciones fueron realizadas mediante fotografías 2D de rostro y dientes obtenidas en condiciones estandarizadas. Se identificó que todos los sujetos portadores de asimetría facial presentaron asimetría dentaria; los desvíos dentarios fueron de casi 7 mm y existió relación estadísticamente significativa entre desvío facial y desvío dentario. Se concluye que los sujetos con asimetría dentaria pueden presentar asimetría facial de forma que la evaluación esqueletal del rostro es necesaria para realizar un diagnóstico correcto.

The aim of this research was to find the relation between facial asymmetry and loss of continuity in median line of maxillary and mandibular teeth. A descriptive study was carried out in 18 subjects with facial asymmetry with surgical indication and observed at the Division of Oral and Maxillofacial Surgery of the Universidad de La Frontera. In all of them the grade of facial asymmetry and the relation in median line of the maxillary and mandibular teeth was evaluated using the t student test considering p value < 0.05; all the evaluations were executed using 2D photography of the face and tooth obtained with standardized conditions. In all the subjects we observed dental asymmetry with almost 7 mm from the median line; statistical relations between dental asymmetry and facial asymmetry. It is concluded that in subjects asking for dental asymmetry treatment a facial evaluation is necessary in view of the relation with skeletal facial deformity.

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La enfermedad de Von Recklinghausen o Neurofibromatosis TipoI (NF1) es una condición autosómica dominante que presenta una variadaexpresión clínica, con manifestaciones que van desde manchas tipo café conleche en piel a severas complicaciones estéticas y funcionales afectando lostejidos óseos y nerviosos. Las manifestaciones orales de la NF1 son comunes,afectando aproximadamente al 72% de los pacientes. Presentamos un casode NF1 con lesiones neurofibromatosas afectando al reborde alveolar inferiory lengua, con indicación de excisión quirúrgica debido a la dificultad dehigiene local(AU)

Von Recklinghausen’s disease, or type I neurofibromatosis(NF-1), is an autosomal dominant condition with a varied clinicalexpression. Disease manifestations may range from café au laitspots of the skin to severe cosmetic and functional complicationsthat affect bone and nervous tissues. Oral manifestations of NF-1are common, affecting approximately 72% of patients. We reporta case of NF-1 with neurofibromatous lesions of the lower alveolarbridge and tongue. Resection was indicated due to the difficultyof maintaining oral hygiene(AU)

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A elasticidade e a distensibilidade da pele são sinais clínicos relevantes. O objetivo era verificar a hiperdistensibilidade cutânea e as cicatrizes atróficas e estabelecer um critério clínico para avaliação da distensibilidade cutânea. Grupo de 27 indivíduos com cicatrizes atróficas (Grupo I) e grupo controle de 10 indivíduos normais sem cicatrizes atróficas (Grupo II). Usou-se um teste clínico de distensibilidade cutânea: tração uniaxial aplicada paralelamente à superfície do braço. Os pacientes eram volutários do Hospital das Clínicas - USP e da Universidade Estadual de Campinas. Resultados - A distensibilidade cutânea foi maior no Grupo I. A deformação da pele foi maior do que 0,4cm e considerada hiperdistensível. A associação da distensibilidade cutânea com cicatrizes atróficas e estrias atróficas foi estatisticamente significante em relação ao grupo controle. No Grupo I houve relação significante com hipermobilidade articular, história de sangramento fácil, púrpura e rupturas cutâneas a pequenos traumas. Conclusões: é possível predizer a formação de cicatrizes atróficas, alargadas e inestéticas, e de estrias atróficas usando o teste clínico de distensibilidade cutânea com deformação acima de 0,4cm, hipermobilidade articular e história de fragilidade dos tecidos. Os indivíduos podem representar formas subclínicas de síndrome de Ehlers-Danlos

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Atracurium besylate is a highly selective nondepolarizing neuromuscular blocking agent routinely used during anesthetic procedures. The commercial presentation of this drug is a mixture of positional isomers, cis-cis, cis-trans, and trans-trans. Reversed-phase high-performance liquid chromatography has been the technique of choice for the analysis of atracurium besylate formulations at the quality control laboratory of Núcleo de Desenvolvimento Cristália (São Paulo, Brazil), a local pharmaceutical company. HPLC analysis is usually conducted under gradient elution using acetonitrile/0.1 M phosphate buffer eluent mixture as mobile phase and an octadecyl silica (ODS)-packed column. The complete elution of the three isomers takes about 1 hr. In this work, an alternative capillary electrophoresis methodology was developed. The complete resolution of all three isomers was accomplished in about 13 min (+20 kV/72 cm, 211 nm direct detection) using a 60-mM phosphate buffer solution (pH 4) containing 20 mM beta-cyclodextrin and 4 M urea. The isomer ratio was found to be 59.1% cis-cis, 35.9% cis-trans, and 5.02% trans-trans (expected ratio: 59:35:6). Laudanosine, a major metabolite of atracurium besylate, was identified in two commercially available formulations, Tracur (Núcleo de Desenvolvimento Cristália) and Tracrium (Glaxo Wellcome, S.A., Rio de Janeiro, Brazil). Its concentration increases considerably during storage of the product, even if the product is stored at low temperatures.

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