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Recent works have called into question whether p-curve can reliably assess the presence of "evidential value" within a set of studies. To examine an as-yet unexplored issue, we examined the method used to identify p-values for inclusion in a p-curve analysis. We developed iterated p-curve analysis (IPA), which calculates and p-curves every permutation for a set of reported p-values, and applied it to the data reported in several published p-curve analyses. Specifically, we investigated two phenomena for which p-curves have been used to evaluate the presence of evidential value: the power pose and the hypothalamic-pituitary-adrenal (HPA) reactivity debates. The iterated p-curve analyses revealed that the p-curve method fails to provide reliable estimates or reproducible conclusions. We conclude that p-curve should not be used to make conclusions regarding the presence or absence of evidence for a specific phenomenon.

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Although Glowacki proposed that peace developed from the relatively recent advent of intergroup norms and tolerance for out-group members, we submit that (a) positive intergroup relations developed from a psychology grounded in the regulation of intragroup relations, (b) the "default" intergroup orientation is uncertainty, and (c) positive intergroup relations likely existed early in our evolutionary history.

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This paper investigates the hemp limecrete mechanical and microstructural performance of a new sustainable and environmental friendly building material. Several studies have investigated the hemp limecrete focusing on the non-structural applications. The newly developed hemp limecrete consists of high mechanical and microstructural properties. The specimens were prepared with varying lengths and proportions of hemp fibers with lime and tested for compressive strength, flexural strength, thermal conductivity and microstructural analysis like SEM and EDS. The study found that the optimal fiber content for making mortars was between 2 and 4%. This conclusion was reached after analyzing the influence of fiber length and ratio on the properties of the mortars. The dry unit weight decreased when the fiber content was higher than 4%. In terms of strength, the study found that the flexural strength of the hemp limecrete improved with an increase in fiber ratio, but the compressive strength decreased. However, with 2% hemp fiber, compressive strengths of 3.48 MPa and above were obtained. The study also highlighted the good thermal insulation properties and dimensional stability of hemp limecrete. These findings have important implications for the use of hemp limecrete as a sustainable building material. The results suggest that hemp limecrete has the potential to be a viable alternative to conventional concrete in specific applications, particularly in areas where environmental sustainability is a priority.

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The Narcissistic Grandiosity Scale (NGS; Rosenthal et al., 2020) is a 16-item adjective-rating scale with scores that measure narcissistic grandiosity, a central feature of the grandiose form of narcissism. The NGS was developed both to measure the narcissistic grandiosity construct and to do so in a way that maximally distinguishes narcissistic grandiosity from nongrandiose self-esteem, a construct with which narcissistic grandiosity is often conflated. Over the past few years, different shortened versions of the NGS have been recommended in the literature. To evaluate these shortened versions, we used a meta-analysis to assess how well scores on each NGS item measured narcissistic grandiosity and distinguished it from self-esteem. Using zero-order and partial correlations from 40 data sets, which included information from 14,938 individual participants, we found that all NGS items correlated moderately with grandiose narcissism and largely retained those relations when controlling for self-esteem as well as narcissistic entitlement. The results help inform researchers about the degree to which items recommended for shorter versions of the NGS meet the scale's theoretical goals. We conclude that, when possible, it is advantageous for researchers to continue to use the full 16-item version of the scale. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

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Spoilage in cooked ham is one of the main challenges where microbial contamination can play a fundamental role. This study aimed to characterize pork-cooked ham's microbial community changes among different food production conditions (formulation and processing) using 16S rRNA sequencing and also to investigate the spoilage bacteria in order to elucidate their contamination route. Samples of three pork-cooked ham references with and without post-pasteurization treatment and in contact with the slicing-packaging conveyor belt and slicer and packager surfaces were performed by 16S rRNA gene sequencing. In order to clarify the contamination route, surfaces were sampled by conventional microbiological methods. Results showed that Leuconostoc spp. was the principal genera in spoiled cooked ham and had no relation neither to formulation nor contact with the slicing-packaging conveyor belt. The contamination route found for Leuconostoc spp. was associated with the storage and packaging zone. In addition, the calculated shelf-life decreased to 57.5% independently of the environment interaction minimization when ham casing permeability was changed and linked to contamination of spoilage bacteria during the slicing and packaging process. This research illustrates how the combined approach provides complementary results to implement suggestions in the facility to reduce the cross-contamination with spoilage bacteria. It also generates tools to comprehend and propose transference models understanding the environmental and intrinsic factors related to microbial transfer rate.

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OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vertical transmission has been investigated extensively. Recently, the World Health Organization (WHO) published strict criteria to classify the timing of mother-to-child transmission of SARS-CoV-2 into different categories. The aim of this study was to investigate the possibility of vertical transmission in asymptomatic SARS-CoV-2-positive women. METHODS: Pregnant women attending for delivery at a perinatology center in Mexico City, Mexico, who had a SARS-CoV-2-positive nasopharyngeal swab 24-48 h before delivery, were asymptomatic at the time of the test and had an obstetric indication for Cesarean section were eligible for inclusion in this study. Amniotic fluid was collected during Cesarean delivery, and neonatal oral and rectal swabs were collected at birth and at 24 h after birth. SARS-CoV-2 detection was carried out using real-time reverse-transcription polymerase chain reaction in all samples. Relevant medical information was retrieved from clinical records. The WHO criteria for classifying the timing of mother-to-child transmission of SARS-CoV-2 were applied to the study population. RESULTS: Forty-two SARS-CoV-2-positive asymptomatic pregnant women fulfilled the inclusion criteria. Twenty-five (59%) women developed mild disease after discharge. Neonatal death occurred in three (7%) cases, of which one had a positive SARS-CoV-2 test at birth and none had coronavirus disease 2019-related symptoms. There were five (12%) cases with strong evidence of intrauterine transmission of SARS-CoV-2, according to the WHO criteria, as amniotic fluid samples and neonatal samples at birth and at 24 h after birth were positive for SARS-CoV-2. Our results also showed that 40-60% of infected neonates would have been undetected if only one swab (oral or rectal) was tested. CONCLUSION: This study contributes evidence to reinforce the potential for vertical transmission of SARS-CoV-2 even in asymptomatic women and highlights the importance of testing more than one neonatal sample in order to increase the detection rate of SARS-CoV-2 in affected cases. © 2021 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

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A creative low-cost and compact mechanical device that mimics the rapid closure of the pistol shrimp claw was used to conduct electrochemical experiments, in order to study the effects of hydrodynamic cavitation on the corrosion of aluminum and steel samples. Current-time curves show significant changes associated with local variations in dissolved O2 concentration, cavitation-induced erosion, and changes in the nature of the surface corrosion products.

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Myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), and remarkably shortens survival. Although JAK2V617F and CALR allele burden are the main transformation risk factors, inflammation plays a critical role by driving clonal expansion toward end-stage disease. NF-κB is a key mediator of inflammation-induced carcinogenesis. Here, we explored the involvement of miR-146a, a brake in NF-κB signaling, in MPN susceptibility and progression. rs2910164 and rs2431697, that affect miR-146a expression, were analyzed in 967 MPN (320 PV/333 ET/314 MF) patients and 600 controls. We found that rs2431697 TT genotype was associated with MF, particularly with post-PV/ET MF (HR = 1.5; p < 0.05). Among 232 PV/ET patients (follow-up time=8.5 years), 18 (7.8%) progressed to MF, being MF-free-survival shorter for rs2431697 TT than CC + CT patients (p = 0.01). Multivariate analysis identified TT genotype as independent predictor of MF progression. In addition, TT (vs. CC + CT) patients showed increased plasma inflammatory cytokines. Finally, miR-146a-/- mice showed significantly higher Stat3 activity with aging, parallel to the development of the MF-like phenotype. In conclusion, we demonstrated that rs2431697 TT genotype is an early predictor of MF progression independent of the JAK2V617F allele burden. Low levels of miR-146a contribute to the MF phenotype by increasing Stat3 signaling.

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Measures of self-esteem frequently conflate two independent constructs: high self-esteem (a normative positive sense of self) and narcissistic grandiosity (a nonnormative sense of superiority). Confusion stems from the inability of self-report self-esteem scales to adequately distinguish between high self-esteem and narcissistic grandiosity. The Narcissistic Grandiosity Scale (NGS) was developed to clarify this distinction by providing a measure of narcissistic grandiosity. In this research, we refined the NGS and demonstrated that NGS scores exhibit good convergent, discriminant, and concurrent validity relative to scores on theoretically relevant measures. NGS scores, when used as simultaneous predictors with scores on a self-esteem measure, related more strongly to phenomena linked to narcissistic grandiosity (e.g., competitiveness, overestimating one's attractiveness, lack of shame), whereas self-esteem scores related more strongly to phenomena crucial to individuals' well-being (e.g., higher levels of optimism and satisfaction with life, and lower levels of depression, worthlessness, and hostility). The NGS provides researchers with a measure to help clarify the distinctions between narcissistic grandiosity and high self-esteem, as well as other facets of narcissism, both in theory and as predictors of important real-life characteristics.

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We present a meta-analysis that investigated the relation between self-reported interpersonal attraction and enacted behavior. Our synthesis focused on (a) identifying the behaviors related to attraction; (b) evaluating the efficacy of models of the relation between attraction and behavior; (c) testing the impact of several moderators, including evaluative threat salience, cognitive appraisal salience, and the sex composition of the social interaction; and (d) investigating the degree of agreement between the meta-analytic findings and an ethnographic analysis. Using a multilevel modeling approach, an analysis of 309 effect sizes (N = 5,422) revealed a significant association (z = .20) between self-reported attraction and enacted behavior. Key findings include: (a) that the specific behaviors associated with attraction (e.g., eye contact, smiling, laughter, mimicry) are those behaviors research has linked to the development of trust/rapport; (b) direct behaviors (e.g., physical proximity, talking to), compared with indirect behaviors (e.g., eye contact, smiling, mimicry), were more strongly related to self-reported attraction; and (c) evaluative threat salience (e.g., fear of rejection) reduced the magnitude of the relation between direct behavior and affective attraction. Moreover, an ethnographic analysis revealed consistency between the behaviors identified by the meta-analysis and those behaviors identified by ethnographers as predictive of attraction. We discuss the implications of our findings for models of the relation between attraction and behavior, for the behavioral expressions of emotions, and for how attraction is measured and conceptualized. (PsycINFO Database Record

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To evaluate the veracity of models of the mere exposure effect and to understand the processes that moderate the effect, we conducted a meta-analysis of the influence of repeated exposure on liking, familiarity, recognition, among other evaluations. We estimated parameters from 268 curve estimates drawn from 81 articles and revealed that the mere exposure effect was characterized by a positive slope and negative quadratic effect consistent with an inverted-U shaped curve. In fact, such curves were associated with (a) all visual, but not auditory stimuli; (b) exposure durations shorter than 10 s and longer than 1 min; (c) both homogeneous and heterogeneous presentation types; and (d) ratings that were taken after all stimuli were presented. We conclude that existing models for the mere exposure effect do not adequately account for the findings, and we provide a framework to help guide future research. (PsycINFO Database Record

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The interaction of the physiological medium and living tissues with the implant surfaces in biological environments is regulated by biopotentials that induce changes in the chemical composition, structure and thickness of the oxide film. In this work, oxide films grown on CoCr alloys at 0.5 V vs Ag/AgCl and 0.7 V vs Ag/AgCl have been characterized through overall and localized electrochemical techniques in a phosphate buffer solution and 0.3% hyaluronic acid. Nanopores of 10-50nm diameter are homogeneously distributed along the surface in the oxide film formed at 0.7 V vs Ag/AgCl. The distribution of the Constant Phase Element studied by local electrochemical impedance spectroscopy showed a three-dimensional (3D) model on the oxide films grown at 0.5 V vs Ag/AgCl and 0.7 V vs Ag/AgCl. This behaviour is especially noticeable in oxide films grown at 0.7 V vs Ag/AgCl, probably due to surface inhomogeneities, and resistive properties generated by the potentiostatic growth of the oxide film.

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Objetivo. Comparar el efecto de 2 métodos de electroestimulación en las siguientes variables: fuerza y antropometría. Método. Se realizó una investigación experimental, aleatoria y simple ciego. Se evaluó a 18 sujetos, distribuidos en: Grupo Corriente TENS Modificada (CTM: n = 6), Grupo Corriente Rusa (CR: n = 6) y Grupo Control (TC: n = 6, sometido a corriente TENS Convencional, considerada en la presente investigación como placebo). Resultados. Al cabo de 8 semanas, solo CTM incrementó la fuerza máxima (p < 0.035) y redujo el grosor del pliegue subcutáneo de la pierna derecha (p < 0.03). Conclusiones. La técnica de electroestimulación con corriente TENS Modificada es efectiva para el entrenamiento muscular (AU)

Objetivo. Comparar o efeito de 2 métodos de eletroestimulação nas seguintes variáveis: força e antropometria. Método. Um estudo experimental, randomizado, cego simples. Foram avaliados 18 indivíduos, distribuídos em: grupo de corrente TENS modificada (CTM: n = 6), grupo corrente russa (CR: n = 6) e grupo controle (TC: n = 6, submetido a corrente TENS convencional, considerada nesta investigação como placebo). Resultados. Após 8 semanas, CTM aumentou a força máxima (p < 0,035) e reduziu a espessura de pregas subcutâneas da coxa direita (p < 0,03). Conclusões. A técnica de eletroestimulação com corrente TENS modificada é eficaz para treinamento muscular (AU)

Objective. To compare the effect of two methods of electrostimulation on the following variables: strength and anthropometry. Method. An experimental, randomized, and simple blind investigation was performed. Eighteen subjects were evaluated distributed into a Modified TENS Current Group (CTM: n = 6), Russian Current Group (CR: n = 6), and a Control Group (TC: n = 6, submitted to traditional TENS current, considered as placebo in this research). Results. After 8 weeks, only CTM obtained an increase in maximal strength (p < 0.035), and a reduction in the subcutaneous fat thickness of the right thigh (p < 0.03). Conclusions. A Modified TENS Current is effective for muscular training (AU)

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An increasing numbers of patients are being diagnosed with asymptomatic early-stage chronic lymphocytic leukemia (CLL), with no treatment indication at baseline. We applied a high-throughput deep-targeted analysis, especially designed for covering widely TP53 and ATM genes, in 180 patients with inactive disease at diagnosis, to test the independent prognostic value of CLL somatic recurrent mutations. We found that 40/180 patients harbored at least one acquired variant with ATM (n=17, 9.4%), NOTCH1 (n=14, 7.7%), TP53 (n=14, 7.7%) and SF3B1 (n=10, 5.5%) as most prevalent mutated genes. Harboring one 'sub-Sanger' TP53 mutation granted an independent 3.5-fold increase of probability of needing treatment. Those patients with a double-hit ATM lesion (mutation+11q deletion) had the shorter median time to first treatment (17 months). We found that a genomic variable: TP53 mutations, most of them under the sensitivity of conventional techniques; a cell phenotypic factor: CD38-positive expression; and a classical marker as ß2-microglobulin, remained as the unique independent predictors of outcome. The high-throughput determination of TP53 status, particularly in this set of patients frequently lacking high-risk chromosomal aberrations, emerges as a key step, not only for prediction modeling, but also for exploring mutation-specific therapeutic approaches and minimal residual disease monitoring.

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The ideal temporary implant should offer enough mechanical support to allow healing of the fracture and then biodegrade and be resorbed by metabolic mechanisms without causing any toxic effect. The aim of this research has been to simultaneously study in situ bone healing and the biodegradation of AZ31 Mg alloy as an osteosynthesis material. The in vivo study was carried out in AZ31 implants with and without Mg-fluoride coating inserted in un-fractured and fractured femurs of Wistar rats for long experimentation time, from 1 to 13 months, by means of computed tomography, histological and histomorphometric analysis. Tomography analysis showed the bone healing and biodegradation of AZ31 implants. The fracture is healed in 100% of the animals, and AZ31 maintains its mechanical integrity throughout the healing process. Biodegradation was monitored, quantifying the evolution of gas over time by 3D composition of tomography images. In all the studied groups, gas pockets disappear with time as a result of the diffusion process through soft tissues. Histomorphometric studies reveal that after 13 months the 46.32% of AZ31 alloy has been resorbed. The resorption of the coated and uncoated AZ31 implants inserted in fractured femurs after 1, 9 and 13 months does not have statistically significant differences. There is a balance between the biodegradation of AZ31 and bone healing which allows the use of AZ31 to be proposed as an osteosynthesis material.

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Epidemiologic studies have revealed that modification of the levels of individual components of the hemostatic system may have effects on the development of thrombosis or hemorrhage. To maintain the necessary equilibrium, the hemostatic system is finely regulated. It is known that acquired factors and/or alterations in genes (single-nucleotide polymorphisms or mutations) may be the cause of interindividual differences or exacerbated levels of hemostatic proteins in plasma, but there are still many non-characterized factors that provoke such variations. The search for new elements, such as microRNAs (miRNAs), a family of small non-coding RNAs that are novel regulators of protein expression, may reveal an additional layer at which to investigate the causes of hemostatic diseases. In this review, we discuss the latest developments in research into the role of miRNAs in the regulation of several hemostatic factors, and the potential use of miRNAs as prognostic or diagnostic tools in hemostasis and thrombosis.

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OBJETIVO: Determinar el impacto generado por el manejo de agroquímicos en la parte alta de la microcuenca Chorro Hondo en el municipio Marinilla, para el establecimiento de acciones que contribuyan al mejoramiento de la calidad de vida y del ambiente. METODOLOGIA: Estudio descriptivo de corte transversal con análisis univariado y bivariado de encuestas a treinta y cinco campesinos en su respectivo predio y seis proveedores, observaciones directas en predios ubicados en los primeros dos mil metros de la microcuenca y muestras de agua, suelo y aire, donde se analizó la presencia de Clorotalonil y Mancozeb, ingredientes activos más comunes entre los agroquímicos utilizados. RESULTADOS : En los treinta y cinco predios, 86% de los campesinos realizaba alguna actividad agropecuaria y 74% aplicaba agroquímicos, asimismo el 58% conocía los riesgos asociados de los productos utilizados, destacándose la intoxicación (47%), el 42% no usaba traje especial y 31% consideraba que el agua estaba contaminada con agroquímicos. La concentración de los ingredientes activos en agua, aire y suelo fue menor del límite de detección de los métodos. DISCUSION:Marinilla presenta una problemática compleja en el manejo de agroquímicos; el Clorotalonil es cancerígeno y el Mancozeb tiene cancelada la licencia de venta; no se cumplen las condiciones básicas de almacenamiento de agroquímicos, transporte y disposición final de sus residuos; y no se utilizan adecuadamente los elementos de protección personal.

OBJECTIVE: to determine the impact generated by the use of agrochemicals in the upper area of the Chorro Hondo micro watershed in the municipality of Marinilla (Colombia)in order to develop measures contributing to environmental and quality of life improvement. METHODOLOGY: a cross sectional,descriptive study with a univariate and bivariate analysis of the survey sanswered by 6 suppliers and 35 farmers who were located in their respective agricultural lands. Additionally, the study included direct observations of the properties located within the first 2000 meters of the micro watershed. Likewise, water, soil and air samples were analyzed in search of Chlorothalonil and Mancozeb, the most common active ingredients of the agrochemicals used in this area. RESULTS :in all of the 35 properties, 86% of the farmers performed some kind of agricultural activity and 74% used agrochemicals.Similarly, 58% of the farmers knew the risks associated with the use of these products, intoxication being the most common(occurring in 47% of the individuals). Moreover, 42% did not use a special suit and 31% felt that the water was contaminated with agrochemicals. The concentration of the active ingredients in the water, air and soil was below the detection limit of the methods. DISCUSSION:Marinilla has a complex set of problems regarding agrochemical handling; Chlorothalonil is carcinogenic, and the sale license for Mancozeb has been canceled; the farmers do not meet the basic requirements for: agrochemical storage, transportation and waste disposal; finally,the farmer do not usethe appropriate personal protectiongear.

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In this paper, two complementary approaches, mathematical modeling and experimental results are combined to identify variables that affect the in vivo biodegradation of magnesium implants. The in vivo corrosion behavior of AZ31 alloy proposed for temporary applications as fixation of bone fractures has been modeled solving the Laplace equation by finite element method (FEM). Bar-shaped AZ31 implants of 1mm diameter and 20mm length were inserted in Wistar rat femurs with and without a fracture. The presence of gas around AZ31 implants inside the femurs has been detected in situ at the epiphysis and in fractured areas by computerized tomography (CT). Examining some in vivo conditions, the model confirms that magnesium-alloy devices have different biodegradation behavior, depending on the thickness of electrolyte at the implantation site and can be used for predicting the biodegradation behavior.

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We describe a model for understanding interpersonal attraction in which attraction can be understood as a product of the initial evaluations we make about others. The model posits that targets are evaluated on two basic dimensions, capacity and willingness, such that affective and behavioral attraction result from evaluations of (a) a target's capacity to facilitate the perceiver's goals/needs and (b) a target's potential willingness to facilitate those goals/needs. The plausibility of the two-dimensional model of attraction is evaluated vis-à-vis the extant literature on various attraction phenomena including the reciprocity of liking effect, pratfall effect, matching hypothesis, arousal effects, and similarity effect. We conclude that considerable evidence across a wide range of phenomena supports the idea that interpersonal attraction is principally determined by inferences about the target's capacity and willingness.

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Objetivo: caracterizar el perfil socio-laboral de los profesionales egresados del programa Administración en Salud de la Universidad de Antioquia. Metodología: estudio descriptivo de corte transversal basado en información primaria mediante encuesta a 356 profesionales egresados del programa entre 1999 y 2008. Se aplicaron técnicas de análisis estadístico descriptivo e inferencial. Según la naturaleza de las variables, se reportan valores absolutos, proporciones, medidas de resumen y tendencia central. Resultados: se trata de un grupo de profesionales jóvenes con edad promedio de 32,5 años, principalmente mujeres, en su mayoría con experiencia laboral profesional después de haberse graduado y con vínculo laboral al momento de la encuesta. El 12,1% reportó estar desempleado. El principal sector de la economía donde laboran es el de servicios, seguido de la construcción. El cargo desempeñado durante su historia laboral más frecuente es el administrativo seguido del operativo. Para la mayoría, sus ingresos salariales no superan los 4 Salarios Mínimos Legales Vigentes (SMLV). Discusión: algunos hallazgos se corresponden con estudios previos de 2001 y 2004. Otras variables contrastan con esos estudios y con otros referentes nacionales. Se concluye que las condiciones de precariedad laboral no son inherentes a la profesión en sí misma sino a las características del mercado laboral del mundo capitalista actual.

OBJECTIVE: To characterize the social and work profiles of the professionals from Universidad de Antioquia (University of Antioquia) who hold a degree in Health Administration.METODHOLOGY: A cross–sectional study based on primary data obtained by surveying 356 graduate professionals between 1999 and 2008. Descriptive and inferential statistical analysis techniques were applied. Depending on the nature of the variables, absolute values, ratios, and summary measures of central tendency were reported. RESULTS: It was a group of young professionals with an average age of 32.5 years. They were mainly women with professional work experience after graduation. They were employed at the time of the survey, but 12.1% of them reported being unemployed. The main sector of the economy where they work is services, followed by construction. Their most common position is that of administrator, followed by operational positions. In most cases, their income doesn't exceed 4 legal minimum wages.DISCUSSION: some findings are consistent with previous studies conducted in 2001 and 2004. Other variables contrast with these studies and with other national references. We conclude that the conditions of job insecurity are not inherent to the profession itself but to the labor market characteristics of the current capitalist world.

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