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1.
Front Sports Act Living ; 6: 1282214, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38344127

RESUMEN

Introduction: The application of muscle force is a determinant of football success as it is inherent to the motor control and sport. The aims of this study are: (1) to describe force variables Isometric Maximal Force (IMF), Concentric Peak Force (CPPF), and Dynamic Strength Index (DSI) in football goalkeepers from different age groups; (2) to compare these variables' behavior between those groups. Methods: The sample was formed by 19 youth players (15.97 ± 1.55 years old) from a first-division Brazilian football team. The CPPF and IMF variables were obtained through the Countermovement jump and isometric squat tests, respectively. For data collection, a force plate (Cefise, Brazil) was used with an acquisition frequency of 600 Hz and mono-axial. The DSI was calculated using the ratio between CPPF and IMF. For data analysis, the sample was separated into clusters by age. After the grouping, a descriptive analysis of the data and a comparison between the groups with p < 0.05. Results: The sample was grouped into three groups (GA, GB, and GC) and one of the individuals did not enter the group, totaling 18 individuals in the analyzed sample. The comparison between the ages of the groups showed a significant difference and small and moderate effect size (ES), validating the cluster strategy. The CPPF and IMF variables showed increased values according to chronological age. CPPF showed a significant difference between GA-GB, (ES = very large) GA-GC (ES = very large), and GB-GC (ES = moderate). The IMF variable had significant differences between GA-GB (ES = moderate) and GA-GC (ES = very large). However, DSI showed significant differences only between GA GB (ES = small) and GB-GC (ES = very large). Conclusions: The CPPF and IMF variables had constant increases and distinct values with an increase according to age, and this did not occur for DSI. The difference between CPPF and IMF compared to DSI bring to light the variability in dynamics and proportionality between muscular force in the concentric phase and maximal force in the isometric regime during the developmental process over chronological age in soccer goalkeepers.

2.
Artículo en Inglés | MEDLINE | ID: mdl-37174139

RESUMEN

Interval training (IT) is a very efficient method. We aimed to verify the chronic effects of IT with different intensities on hemodynamic, autonomic and cardiorespiratory variables in the elderly. Twenty-four physically active elderly men participated in the study and were randomized into three groups: Training Group A (TGA, n = 8), Training Group B (TGB, n = 8) and control group (CG, n = 8). The TGA and TGB groups performed 32 sessions (48 h interval). TGA presented 4 min (55 to 60% of HRmax) and 1 min (70 to 75% of HRmax). The TGB training groups performed the same protocol, but performed 4 min at 45 to 50% HRmax and 1 min at 60 to 65% HRmax. Both training groups performed each set six times, totaling 30 min per session. Assessments were performed pre (baseline) after the 16th and 32nd intervention session. The CG performed only assessments. Hemodynamic, autonomic and cardiorespiratory (estimated VO2max) variables were evaluated. There were no significant differences between protocols and times (p > 0.05). However, the effect size and percentage delta indicated positive clinical outcomes, indicating favorable responses of IT. IT may be a strategy to improve hemodynamic, autonomic and cardiorespiratory behavior in healthy elderly people.


Asunto(s)
Hemodinámica , Consumo de Oxígeno , Masculino , Humanos , Anciano , Consumo de Oxígeno/fisiología , Frecuencia Cardíaca/fisiología
4.
Front Psychol ; 13: 987149, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36092047

RESUMEN

Competitive sports involve physiological, technical and psychological skills, which influence directly on individuals' performance. This study aims to investigate the levels of perceived stress and Heart Rate Variability (HRV) before and after matches with victory and defeat in professional eSports athletes. Our hypothesis was that the winners would have better autonomic and stress responses after match, thus corroborating the literature on neurocardiac connections. Fifty male eSport players were selected players from 10 different Brazilian teams. The experiment was carried out in 2 sessions. Firstly, after signing the informed consent form, 24 h before the game, anthropometric, physical activity levels and time of expertise data were recorded only for sample characterization and the players were familiarized with the perceived stress scale-10 (PSS-10) and the HRV measurements. Secondly, players performed the PSS-10 and HRV recording at rest by 10 min 60 and 30 min before the game (i.e., baseline time) and 10 min after the end of the game. Overall, concerning PSS-10 our findings show that VG had significant reduced scores in post-game time compared to baseline (BL) and pre-game times, while DG had significant increased scores in post-game time compared to BL and pre-game times. Regarding HRV, our results demonstrate that VG had significant increase in RR, SDNN, rMSSD, pNN50 and HF, and significant decrease in LF and LF/HF, while DG had a significant decrease in RR, SDNN, rMSSD and HF, and significant increase in LF and LF/HF. It was observed that VG had better HRV responses (greater parasympathetic activation) as well as lower levels of perceived stress, while DG had worst HRV responses (greater sympathetic activation) and higher levels of perceived stress.

5.
Expert Rev Neurother ; 22(9): 771-780, 2022 09.
Artículo en Inglés | MEDLINE | ID: mdl-36168890

RESUMEN

INTRODUCTION: Exploring the potential of exercise in the rehabilitation process of patients with Parkinson's (PD) may be an interesting treatment perspective. Exercise-induced responses derived from neurotrophic elements appear to ameliorate the decline in neurodegeneration. Despite this understanding, the literature needs to be updated. AREAS COVERED: Our review focuses on: a) the key mechanisms of exercise on PD, highlighting mainly the responses related to neuroplasticity; b) the effects induced by different traditional types of exercise, also highlighting the effects of complementary therapies related to movement; c) the volume of exercise required to support efficient results are explored in the context of PD. Additionally, the proposition of new clinical application strategies in the context of PD will also be determined. EXPERT OPINION: It is suggested that different intensities of aerobic exercise be explored for the treatment of PD. The results associated with high intensity seem promising for performance, physiological and clinical parameters, such as BDNF production and cognition. On the other hand, the diversification of tasks and repetition of motor gestures appear as consistent arguments to exercise prescription. Finally, for future investigations, the neuromodulation strategy in association with aerobic exercise appears as a potential inducer of benefits on gait and cognitive function.


Asunto(s)
Enfermedad de Parkinson , Humanos , Ejercicio Físico/fisiología , Marcha , Terapia por Ejercicio/métodos , Cognición
6.
Medicina (Kaunas) ; 58(8)2022 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-36013564

RESUMEN

Background and Objectives: Fibromyalgia are heterogeneous and differ from patient to patient; however, the most reported are general myalgia and at specific points associated with fatigue and certain psychological adversities. Physical activity can mitigate the effects of the symptoms. However, the associations between fibromyalgia-related fatigue, self-esteem, anxiety, depression, satisfaction with life and physical activity are unclear. Therefore, the aim of the present study was to understand the associations between these symptoms and whether there are differences between these associations across two distinct cultures. Materials and Methods: A total of 473 women aged between 28 and 75 years (M = 49.27; SD ± 8.28) completed five questionnaires about fibromyalgia-related fatigue, physical activity, anxiety, depression, self-esteem, and satisfaction with life. Results: Fibromyalgia-related fatigue was positively associated with depression and anxiety, depression and anxiety were negatively associated with self-esteem, self-esteem was positively associated with satisfaction with life, satisfaction with life was positively associated with physical activity and there were no differences in terms of the perceptions and associations of these variables between Portuguese and Brazilian patients. Conclusions: Our results showed the significant role of associations between these variables and a similarity in the perception and relationship of the variables between the two cultures.


Asunto(s)
Fibromialgia , Adulto , Anciano , Ansiedad/complicaciones , Ansiedad/psicología , Brasil/epidemiología , Depresión/complicaciones , Depresión/psicología , Ejercicio Físico , Fatiga/complicaciones , Femenino , Fibromialgia/complicaciones , Fibromialgia/psicología , Humanos , Análisis de Clases Latentes , Persona de Mediana Edad , Satisfacción del Paciente , Satisfacción Personal , Portugal , Calidad de Vida/psicología , Autoimagen , Encuestas y Cuestionarios
7.
Expert Rev Neurother ; 22(1): 53-64, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-35077254

RESUMEN

INTRODUCTION: In the last few decades, exercise has been explored as a potential tool to reduce symptoms experienced by patients with panic disorder (PD). This systematic review aims to assess the effects of regular exercise interventions on panic severity, global anxiety, and depression symptoms of these patients. AREAS COVERED: A search was conducted on PubMed, ISI Web of Science, and Cochrane Central Register of Controlled Trials using search terms related to PD and exercise. Eight trials were included, Furthermore, regular exercise programs presented different methodological characteristics. There is o clear evidence indicating that regular exercise programs (at least two 20-minute sessions per week for at least 6 weeks) reduce panic-related symptoms. Regular exercise is effective in improving global anxiety measures and depression. EXPERT OPINION: Continuous aerobic exercise is the main type of intervention in the literature, generally providing a limited prescription. Currently, it is recommended the interval training, with intense and shorter stimuli, and long-term duration trials. However, despite the use of self-selected intensities and control based on the internal load be interesting as recommendation to increase adherence, careful is needed regarding training prescription due to scarce evidence.


Asunto(s)
Trastorno de Pánico , Ansiedad , Trastornos de Ansiedad , Ejercicio Físico , Terapia por Ejercicio , Humanos , Trastorno de Pánico/terapia , Calidad de Vida
8.
Clin Pract Epidemiol Ment Health ; 18: e174501792209270, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-37274860

RESUMEN

Previous research has recently shown that high cognitive and somatic anxiety and low self-confidence, before and during sport competitions have a significant correlation with heart rate variability (HRV) changes and can reduce overall athletic performance. Therefore, interventions, such as transcranial direct current stimulation (tDCS), can be a potential tool to reduce psychophysiological anxiety-related and enhance athletic performance. We present a case of a male professional athlete of eSports. We explored the effects of a single session of anodal tDCS (a-tDCS) at 2mA over the dosrsolateral prefrontal cortex (DLPFC) on competitive anxiety and HRV assessed in baseline (BL), pre-tDCS, post-tDCS and post-game moments and compared between moments. Here, we found a decrease in somatic and cognitive anxiety, as well as an increase in self-confidence and in SDNN index in the post-tDCS moment compared with BL, pre-tDCS and post-game moments. These findings can be a result of an acute change in the attentional state, influencing the processing of threatening information essential for cognitive anxiety and of a self-regulatory process, which can regulate physiological arousal response, such as HRV.

9.
Cien Saude Colet ; 26(suppl 3): 5303-5313, 2021.
Artículo en Portugués | MEDLINE | ID: mdl-34787221

RESUMEN

The scope of this paper was to analyze the impact of motivational determinants in enjoyment and persistence in physical exercise among practitioners of physical exercise. In total, 967 gym and health club exercise practitioners aged between 18 and 65 (M=45.08; SD=13.76) were recruited for analysis. All participants had more than six months of regular exercise practice. Participants completed and validated scales in the exercise context duly translated into Portuguese, assessing interpersonal behaviors, basic psychological needs, and behavioral regulation. Persistence was measured using computerized records considering persistent exercisers as being those who were exercising at similar frequencies as those self-reported at the initial assessment. Results showed that the measurement and structural model fit the data. Several significant effects were found supporting previous literature. Indirect effects showed enjoyment to play a crucial role on exercise persistence, both by the significant effect via autonomous and controlled motivation. In essence, activities that give pleasure that gym and health club exercisers experience during the practice of physical exercise can be the key variable of long-term persistence.


Como objetivo deste trabalho, definiu-se analisar os efeitos indiretos de determinantes motivacionais no divertimento e na persistência em praticantes de exercício físico regular. Participaram ao todo 967 praticantes de exercício em ginásio e health clubs, com idades compreendidas entre 18 e 65 anos (M=45,08; DP=13,76). Todos os participantes tinham mais de 6 meses de experiência regular em exercício físico. Os participantes preencheram ao todo questionários traduzidos e validados para a língua portuguesa no contexto do exercício físico, que examinavam a perceção dos comportamentos interpessoais, as necessidades psicológicas básicas, a regulação da motivação e o divertimento. A persistência foi medida através de registos eletrónicos, considerando um praticante persistente aquele que tivesse uma frequência semanal similar aquela auto-reportada no momento inicial. A maioria das regressões são significativas, confirmado os pressupostos da literatura existente. Os efeitos indiretos mostram que o divertimento desempenha um papel crucial na persistência, tanto por via motivação autónoma, como por via motivação controlada. Em suma, atividades promotoras do prazer que os praticantes de ginásio e health club experienciam durante a prática de exercício físico poderão ser a variável chave na persistência a longo prazo.


Asunto(s)
Motivación , Placer , Adolescente , Adulto , Anciano , Ejercicio Físico , Conductas Relacionadas con la Salud , Humanos , Persona de Mediana Edad , Autonomía Personal , Adulto Joven
10.
Ciênc. Saúde Colet. (Impr.) ; Ciênc. Saúde Colet. (Impr.);26(supl.3): 5303-5313, Oct. 2021. tab, graf
Artículo en Portugués | LILACS | ID: biblio-1345739

RESUMEN

Resumo Como objetivo deste trabalho, definiu-se analisar os efeitos indiretos de determinantes motivacionais no divertimento e na persistência em praticantes de exercício físico regular. Participaram ao todo 967 praticantes de exercício em ginásio e health clubs, com idades compreendidas entre 18 e 65 anos (M=45,08; DP=13,76). Todos os participantes tinham mais de 6 meses de experiência regular em exercício físico. Os participantes preencheram ao todo questionários traduzidos e validados para a língua portuguesa no contexto do exercício físico, que examinavam a perceção dos comportamentos interpessoais, as necessidades psicológicas básicas, a regulação da motivação e o divertimento. A persistência foi medida através de registos eletrónicos, considerando um praticante persistente aquele que tivesse uma frequência semanal similar aquela auto-reportada no momento inicial. A maioria das regressões são significativas, confirmado os pressupostos da literatura existente. Os efeitos indiretos mostram que o divertimento desempenha um papel crucial na persistência, tanto por via motivação autónoma, como por via motivação controlada. Em suma, atividades promotoras do prazer que os praticantes de ginásio e health club experienciam durante a prática de exercício físico poderão ser a variável chave na persistência a longo prazo.


Abstract The scope of this paper was to analyze the impact of motivational determinants in enjoyment and persistence in physical exercise among practitioners of physical exercise. In total, 967 gym and health club exercise practitioners aged between 18 and 65 (M=45.08; SD=13.76) were recruited for analysis. All participants had more than six months of regular exercise practice. Participants completed and validated scales in the exercise context duly translated into Portuguese, assessing interpersonal behaviors, basic psychological needs, and behavioral regulation. Persistence was measured using computerized records considering persistent exercisers as being those who were exercising at similar frequencies as those self-reported at the initial assessment. Results showed that the measurement and structural model fit the data. Several significant effects were found supporting previous literature. Indirect effects showed enjoyment to play a crucial role on exercise persistence, both by the significant effect via autonomous and controlled motivation. In essence, activities that give pleasure that gym and health club exercisers experience during the practice of physical exercise can be the key variable of long-term persistence.


Asunto(s)
Humanos , Adolescente , Adulto , Anciano , Adulto Joven , Placer , Motivación , Ejercicio Físico , Conductas Relacionadas con la Salud , Autonomía Personal , Persona de Mediana Edad
11.
Medicina (Kaunas) ; 57(4)2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33915694

RESUMEN

Background and Objectives: The current literature demonstrates that different cultures have different perceptions of the symptoms of Fibromyalgia Syndrome (FM). The aim of the study was to explore the differences between Brazilian and Portuguese patients with FM in their fatigue experience and to measure the differences in the perception of fatigue according to age and duration of diagnosis. Materials and Methods: In total, 209 Portuguese women aged between 21 and 75 years old (M = 47.44; SD = 10.73) and 429 Brazilian women aged between 18 and 77 years old (M = 46.51; SD = 9.24) were recruited to participate in the present study. Participants filled out the items in the Multidimensional Daily Fatigue-Fibromyalgia-17 Diary (MDF-Fibro-17), a specific tool to measure the level of five components of FM-related fatigue. Results: The results showed a greater perception of all of the components of fatigue in the Brazilian sample. No significant differences were found related to the age and duration of FM diagnosis. Conclusions: Overall, there are significant differences in fatigue symptoms between Portuguese and Brazilian women with FM, suggesting that cultural and geographical differences should be considered when describing fatigue-related symptoms in women with FM.


Asunto(s)
Fibromialgia , Adulto , Anciano , Brasil , Fatiga/epidemiología , Fatiga/etiología , Femenino , Fibromialgia/complicaciones , Fibromialgia/diagnóstico , Fibromialgia/epidemiología , Humanos , Persona de Mediana Edad , Portugal , Encuestas y Cuestionarios , Adulto Joven
12.
Artículo en Inglés | MEDLINE | ID: mdl-33916018

RESUMEN

Competitive sports involve physical and cognitive skills. In traditional sports, there is a greater dependence on the development and performance of both motor and cognitive skills, unlike electronic sports (eSports), which depend much more on neurocognitive skills for success. However, little is known about neurocognitive functions and effective strategies designed to develop and optimize neurocognitive performance in eSports athletes. One such strategy is transcranial direct current stimulation (tDCS), characterized as a weak electric current applied on the scalp to induce prolonged changes in cortical excitability. Therefore, our objective is to propose anodal (a)-tDCS as a performance-enhancing tool for neurocognitive functions in eSports. In this manuscript, we discussed the neurocognitive processes that underlie exceptionally skilled performances in eSports and how tDCS could be used for acute modulation of these processes in eSports. Based on the results from tDCS studies in healthy people, professional athletes, and video game players, it seems that tDCS is applied over the left dorsolateral prefrontal cortex (DLPFC) as a potential performance-enhancing tool for neurocognition in eSports.


Asunto(s)
Deportes , Estimulación Transcraneal de Corriente Directa , Juegos de Video , Humanos , Corteza Prefrontal
14.
Expert Rev Neurother ; 20(11): 1099-1107, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32762382

RESUMEN

INTRODUCTION: Similar effects in reducing the symptoms of the mood disorder are reported in the literature compared the action of drugs and aerobic exercise sessions, demonstrating the potential of exercise in the control and mood stabilization. Therefore, there are many reasons to believe that the increased cardiorespiratory fitness (VO2max) can be an important means of protection and a reducing potential of physical and mental damage in bipolar disorders (BD). This review will highlight the current pattern of response of exercise on the pathophysiology of BD, relating the possible mechanisms, and hypotheses based on exercises. AREAS COVERED: The mechanism of monoaminergic action and its relationship with exercise, role of physical conditioning and increased VO2Max on neurotrophin release, and new perspectives on long-term exercise will be reviewed. EXPERT OPINION: The adaptations to training, although little explored in the context of BD, can induce the expression of substances that co-regulate several processes related to the pathophysiology of BD. Furthermore, high intensity interval training (HIIT) can also be adjusted to improve the physical fitness and health in patients with BD. Future research is needed to adopt a training strategy that is both time efficient and adequate for the population in question.


Asunto(s)
Trastorno Bipolar/metabolismo , Trastorno Bipolar/terapia , Terapia por Ejercicio , Promoción de la Salud , Entrenamiento de Intervalos de Alta Intensidad , Terapia por Ejercicio/métodos , Entrenamiento de Intervalos de Alta Intensidad/métodos , Humanos
15.
J Clin Med ; 9(8)2020 Jul 22.
Artículo en Inglés | MEDLINE | ID: mdl-32707855

RESUMEN

The Multidimensional Daily Diary of Fatigue-Fibromyalgia-17 (MDF-fibro-17) is an instrument that measures the different components of fibromyalgia-related fatigue symptoms. The current study aims to examine the factor structure of the MDF-fibro-17 in a sample of Portuguese and Brazilian patients diagnosed with fibromyalgia. Additionally, a cross-cultural analysis was carried out on these samples to understand the multidimensional complexity of examining the different dimensions of fatigue in patients with different cultural backgrounds and how fibromyalgia impacts patients with this syndrome. A confirmatory factor analysis was performed to examine the psychometric properties of the measure. Additionally, a multigroup analysis was carried out on the samples of these two cultures to examine measurement invariance. In total, 209 Portuguese women aged between 21 and 75 years (M = 47.44; SD = 10.73) and 429 Brazilians women aged between 16 and 77 years (M = 46.51; SD = 9.24) participated in this study. The results revealed that the measurement model provided an acceptable fit to the data in both the Portuguese and Brazilian samples, also displaying acceptable convergent and discriminant validity. In addition, the model showed acceptable internal consistency and was invariant between cultures. In sum, the MDF-fibro-17 is a valid measure that offers a unique assessment of fatigue symptoms in Portuguese and Brazilian women with fibromyalgia.

16.
Artículo en Inglés | MEDLINE | ID: mdl-32508964

RESUMEN

Autistic Spectrum Disorder (ASD) is a complex neurodevelopmental disorder associated with various etiologies and characterized by deficits in social interaction, emotional reciprocity, communication, motor skills and cognitive functions. Studies have proposed that limited levels of physical activity and late motor skills and fitness, particularly in children and adolescents with ASD, may accentuate social and emotional deficits. In view of this, exergames, which are active video-games, can be considered a low-cost and safe type of exercise for children and adolescents with ASD, since they are more enjoyable than ordinary physical activities, influencing on treatment adherence. Thus, our study aims to evidence the effects of exergames on physical fitness, cognitive functions, and repetitive behaviors in children and adolescents with ASD. Despite the small number of studies investigating the effects of exergames as new strategy in children and adolescents with ASD, results suggest exergames as potential tool for the treatment of children and adolescents with ASD for improvement in physical fitness, cognitive functions and repetitive behavior. Our review pointed towards the importance of exergames for children and adolescents with ASD. Despite few studies conducted about this issue, we can consider exergames a potential tool to increase physical fitness, cognitive functions and to decrease repetitive behavior in children and adolescents with ASD. Moreover, health professionals should be careful when attempting to help this population, because the current literature is unclear yet about the improvement of ASD features through exergames.

17.
Artículo en Inglés | MEDLINE | ID: mdl-32512735

RESUMEN

Teacher-endorsed supporting behaviors present themselves as key influencers of student adaptive academic and social functions. The objective of this paper was twofold. First, this study sought to test a model in which student-perceived autonomy support was associated with group cohesion, considering the mediating role of basic psychological needs satisfaction and intrinsic motivation. Second, the current study examined the dimensionality of the model across five Western countries, namely Spain, Portugal, Brazil, Chile, and Mexico. A convenience sample of 3033 college students (Mage = 21.51 ± SD = 3.71) were recruited for the analysis. The results revealed that perceived autonomy support was positively associated with needs satisfaction, being consequently associated with intrinsic motivation and, ultimately, with group cohesion. Additionally, a multigroup analysis revealed that the model was invariant across college students from the different countries. The current results are discussed around the promotion of teacher uses of autonomy-supportive behaviors fostering adaptive outcomes in students regarding positive social relations and that the cultures of Ibero-American countries are equivalent in this process.


Asunto(s)
Grupo Paritario , Autonomía Personal , Estudiantes , Brasil , Chile , Humanos , México , Motivación , Portugal , Apoyo Social , España
18.
Psychopharmacology (Berl) ; 237(7): 2055-2073, 2020 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32472163

RESUMEN

RATIONALE: The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. OBJECTIVES: We investigated the effects of bexarotene (Bexa, a RXR agonist) or UVI 3003 (UVI, a RXR antagonist) on sleep, sleep homeostasis, levels of neurochemical related to sleep modulation, and c-Fos and NeuN expression. METHODS: The sleep-wake cycle and sleep homeostasis were analyzed after application of Bexa or UVI. Moreover, we also evaluated whether Bexa or UVI could induce effects on dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine contents, collected from either the nucleus accumbens or basal forebrain. In addition, c-Fos and NeuN expression in the hypothalamus was determined after Bexa or UVI treatments. RESULTS: Systemic application of Bexa (1 mM, i.p.) attenuated slow-wave sleep and rapid eye movement sleep. In addition, Bexa increased the levels of dopamine, serotonin, norepinephrine epinephrine, adenosine, and acetylcholine sampled from either the nucleus accumbens or basal forebrain. Moreover, Bexa blocked the sleep rebound period after total sleep deprivation, increased in the hypothalamus the expression of c-Fos, and decreased NeuN activity. Remarkably, UVI 3003 (1 mM, i.p.) induced opposite effects in sleep, sleep homeostasis, neurochemicals levels, and c-Fos and NeuN activity. CONCLUSIONS: The administration of RXR agonist or antagonist significantly impaired the sleep-wake cycle and exerted effects on the levels of neurochemicals related to sleep modulation. Moreover, Bexa or UVI administration significantly affected c-Fos and NeuN expression in the hypothalamus. Our findings highlight the neurobiological role of RXR on sleep modulation.


Asunto(s)
Bexaroteno/farmacología , Ácidos Cumáricos/farmacología , Receptores X Retinoide/metabolismo , Fases del Sueño/efectos de los fármacos , Fases del Sueño/fisiología , Tetrahidronaftalenos/farmacología , Animales , Masculino , Núcleo Accumbens/efectos de los fármacos , Núcleo Accumbens/metabolismo , Ratas , Ratas Wistar , Receptores Citoplasmáticos y Nucleares/agonistas , Receptores Citoplasmáticos y Nucleares/antagonistas & inhibidores , Receptores Citoplasmáticos y Nucleares/metabolismo , Receptores X Retinoide/agonistas , Receptores X Retinoide/antagonistas & inhibidores
19.
Rev. Psicol. Saúde ; 12(1): 115-126, jan.-abr. 2020.
Artículo en Inglés | LILACS-Express | LILACS | ID: biblio-1092163

RESUMEN

Depression represents a common public health problem in the world. Depression in the elderly appears to follow a vulnerability-stress model, with an interaction between individual vulnerabilities, including genetic factors, age-related cognitive and neurobiological changes, and a variety of stressful events that occur more frequently in advanced ages, such as grief, financial problems, and reduction in autonomy/functionality. In the last decades, several studies have indicated that exercise can be effective in preventing or reducing depressive symptoms, both in healthy and psychiatric populations. Due to the scientific community's interest in the efficacy and safety of physical exercise as complementary therapy for depressed elderly patients, we conduct an opinion study on the subject. Despite the researchers' efforts, in the last decades little progress has been made in verifying the efficacy of exercise in geriatric depression.


A depressão representa um problema comum de saúde pública no mundo. A depressão em idosos parece seguir um modelo de vulnerabilidade-estresse, com uma interação entre vulnerabilidades individuais, incluindo fatores genéticos, mudanças cognitivas e neurobiológicas relacionadas à idade, e uma variedade de eventos estressantes que ocorrem mais frequentemente em idades avançadas, como luto, problemas financeiros e redução da autonomia/funcionalidade. Nas últimas décadas, vários estudos indicaram que o exercício pode ser eficaz na prevenção ou redução dos sintomas depressivos, tanto em populações saudáveis como psiquiátricas. Devido ao interesse da comunidade científica na eficácia e segurança do exercício físico como terapia complementar para idosos deprimidos; realizamos um estudo de opinião sobre o assunto. Apesar dos esforços dos pesquisadores, nas últimas décadas pouco progresso foi feito na verificação da eficácia do exercício na depressão geriátrica.


La depresión representa un problema común de salud pública en el mundo. La depresión en los ancianos parece seguir un modelo de vulnerabilidad-estrés, con una interacción entre las vulnerabilidades individuales, incluidos factores genéticos, cambios cognitivos y neurobiológicos relacionados con la edad, y una variedad de eventos estresantes que ocurren con mayor frecuencia en edades avanzadas, como el duelo, problemas financieros y reducción de la autonomía/funcionalidad. En las últimas décadas, varios estudios han indicado que el ejercicio puede ser eficaz para prevenir o reducir los síntomas depresivos, tanto en poblaciones sanas como psiquiátricas. Debido al interés de la comunidad científica en la eficacia y seguridad del ejercicio físico como terapia complementaria para pacientes ancianos deprimidos, realizamos un estudio de opinión sobre el tema. A pesar de los esfuerzos de los investigadores, en las últimas décadas se ha avanzado poco en la verificación de la eficacia del ejercicio en la depresión geriátrica.

20.
Curr Neuropharmacol ; 18(2): 97-108, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31368874

RESUMEN

Aging is an inevitable process that involves changes across life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have demonstrated that aging will increase its worldwide rate in the coming years. The research on chronic diseases of the elderly is important to gain insights into this growing global burden. Novel therapeutic approaches aimed for treatment of age-related pathologies have included the endocannabinoid system as an effective tool since this biological system shows beneficial effects in preclinical models. However, and despite these advances, little has been addressed in the arena of the endocannabinoid system as an option for treating sleep disorders in aging since experimental evidence suggests that some elements of the endocannabinoid system modulate the sleep-wake cycle. This article addresses this less-studied field, focusing on the likely perspective of the implication of the endocannabinoid system in the regulation of sleep problems reported in the aged. We conclude that beneficial effects regarding the putative efficacy of the endocannabinoid system as therapeutic tools in aging is either inconclusive or still missing.


Asunto(s)
Endocannabinoides/farmacología , Endocannabinoides/fisiología , Trastornos del Sueño-Vigilia/tratamiento farmacológico , Trastornos del Sueño-Vigilia/fisiopatología , Anciano , Envejecimiento , Ritmo Circadiano , Humanos , Receptores de Cannabinoides , Sueño
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